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Improving outcomes of critically-ill patients with acquired brain injury

Research team and collaborators

  • (opens in a new window)The Irish Critical Care-Clinical Trials Network: team of clinician-researchers, project managers, research coordinators and researchers coordinating ICC-CTN’s ABI programme throughout Ireland and internationally.
  • Team leaders: Professor Alistair Nichol, Dr Kate Ainscough, Dr Leanne Hays, Ms Kathy Brickell, Professor Patrick Murray, Ms Alex Sherry, Ms Sian Donnelly, Ms Aideen Sharry
  • ANZIC-RC and TTM trials group: ANZIC-RC (an international methods centre based in Melbourne, Australia) led many of these studies globally and has a long-standing successful collaboration with the ICC-CTN. The TTM trials group led the TTM2 trial with successful harmonisation with the TAME trial.
  • Irish researchers: TAME and its associated biobank have brough together Ireland’s largest hospital group (Ireland East) and largest university (UCD) with Irish investigators, sites and key laboratory supports across Irish Medical Universities.
  • Ms Ellen Conlon, Research Officer, Acquired Brain Injury Ireland


Funding

  • TAME was supported by grants from the Health Research Board (HRB) Ireland, NHMRC Australia and NZ HRC. Public Engagement and knowledge dissemination was funded by an HRB Knowledge Translation Award and UCD PPI Ignite award.
  • EPO-TBI was supported by grants from the National Health and Medical Research Council of Australia and the Transport Accident Commission of Victoria.
  • The POLAR trial was supported by grants from the National Health and Medical Research Council of Australia; the Victorian Neurotrauma Initiative (VNI for the Transport Accident Commission, Victoria, Australia); the Teaching Hospital of Besançon, France; and Health Research Board of Ireland Clinical Trial Network Program.
  • TTM2 is supported by independent research grants from nonprofit or governmental agencies (the Swedish Research Council [Vetenskapsrådet], Swedish Heart–Lung Foundation, Stig and Ragna Gorthon Foundation, Knutsson Foundation, Laerdal Foundation, Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research, and Regional Research Support in Region Skåne) and by governmental funding of clinical research within the Swedish National Health Service. It collaborated with the ICC-CTN and the TAME trial.
  • EPO-TRAUMA is supported by Health Research Board Ireland, Medical Research Futures Fund and Health Research Council of New Zealand.
  • BONANZA is supported by project grants from the Health Research Board in Ireland, National Health & Medical Research Council and the Medical Research Future fund. The study also has an unrestricted commitment by Integra Neurosciences in consumables and monitors to enable the trial.
  • LOGICAL is supported by a NHMRC Clinical Trials and Cohort Studies Grant.

Project websites


Published trials


Selected guidelines influenced

POLAR influenced guidelines in the EU, the UK, Australia, Chile and the US

TTM2 influenced guidelines in the US, Europe, the UK, the Middle East

 EPO-TBI influenced guidelines in Finland, the US and the UK

 
Selected media

 
Selected project metrics

  • Cross-project: >4700 participants, 22 countries, >20,000 social media views, 1 global/European network established, 1 Critical Care PPI established, 2 ABI-PPI groups established
  • TAME (2023): 15 news articles, 14 citations
  • POLAR (2018): 7 news articles, 11 blogs, 149 citations, 7 book citations, 5 international guidelines
  • TTM2 (2021): 464 citations, 11 blogs, 10 international guidelines
  • EPO-TBI (2015): 193 citations, 11 book citations, 5 international guidelines


Selected awards

  • Resuscitation Science Symposium 2022, Ian G. Jacobs Award
  • Runner up, ACTA Clinical Trial of the Year, 2016


Selected academic outputs

Contact UCD Research

UCD Research, University College Dublin, Belfield, Dublin 4, Ireland.
T: +353 1 716 4000 |