Research Publications

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. Acevedo, A., Jones, A. E., Danna, B. T., Turner, R., Montales, K. P., Benincá, C., Reue, K., Shirihai, O. S., Stiles, L., Wallace, M., Wang, Y., Bertholet, A. M., & Divakaruni, A. S. (2024). J Biol Chem, 300(3), 105702. (opens in a new window)https://doi.org/10.1016/j.jbc.2024.105702

Laxative Properties of Microencapsulated Oleic Acid Delivered to the Distal Small Intestine in Patients with Constipation after Bariatric Surgery or Treatment with Glucagon-Like- Peptide 1 Analogues. Al-Humadi, A. W., Al-Najim, W., Bleiel, S., & le Roux, C. W. (2024). Obes Surg, 34(10), 3807-3812. (opens in a new window)https://doi.org/10.1007/s11695-024-07492-y

Liver fibrosis and liver stiffness in patients with obesity and type 1 diabetes. Al-Ozairi, E., Irshad, M., AlKandari, J., Mashankar, A., Alroudhan, D., & le Roux, C. W. (2024). Diabetes Obes Metab, 26(9), 4052-4059. (opens in a new window)https://doi.org/10.1111/dom.15760

Reformulating ice cream to improve postprandial glucose response: an opportunity for industry to create shared value. Al-Ozairi, E., Mandani, Y., Alfaleh, G., Raj, J., Alshammari, S., & Le Roux, C. W. (2024). Front Nutr, 11, 1349392. (opens in a new window)https://doi.org/10.3389/fnut.2024.1349392

Obesity Treatments to Improve Type 1 Diabetes (OTID): a randomized controlled trial of the combination of glucagon-like peptide 1 analogues and sodium-glucose cotransporter 2 inhibitors-protocol for Obesity Treatments to Improve Type 1 Diabetes (the OTID trial). Al-Ozairi, E., Narula, K., Miras, A. D., Taghadom, E., Samad, A. E., Al Kandari, J., Alyosef, A., Mashankar, A., Al-Najim, W., & le Roux, C. W. (2024). Trials, 25(1), 129. (opens in a new window)https://doi.org/10.1186/s13063-024-07930-3

Prevalence of obesity in people with and without type 1 diabetes across Belgium, Kuwait, and Mexico: an IMI2 SOPHIA study. Al Ozairi, E., Steenackers, N., Pazmino, S., Alattar, A. T., Al Kandari, J., Almeda-Valdes, P., Antonio-Villa, N. E., Delfin, C., Faradji, R. N., García-Tuomola, A. A., Irshad, M., Longenecker, J. C., Rosen, J., Hurtado Del Pozo, C., Sparsø, T., Lavens, A., Mathieu, C., Van der Schueren, B., & le Roux, C. W. (2024). EClinicalMedicine, 77, 102869. (opens in a new window)https://doi.org/10.1016/j.eclinm.2024.102869

Weight loss response in patients with obesity treated with injectable semaglutide in a real-world setting. Alabduljabbar, K., Alsaqaaby, M., Neff, K. J., Crotty, M., & le Roux, C. W. (2024). Endocrine, 83(2), 392-398. (opens in a new window)https://doi.org/10.1007/s12020-023-03534-0

Perceived Benefits of Bariatric Surgery: Patient Perspectives. Alsaqaaby, M. S., Alabduljabbar, K. A., Alruwaili, H. R., Neff, K. J., Heneghan, H. M., Pournaras, D. J., & Le Roux, C. W. (2024). Obes Surg, 34(2), 583-591. (opens in a new window)https://doi.org/10.1007/s11695-023-07030-2

Sex, race, and BMI in clinical trials of medications for obesity over the past three decades: a systematic review. Alsaqaaby, M. S., Cooney, S., le Roux, C. W., & Pournaras, D. J. (2024). Lancet Diabetes Endocrinol, 12(6), 414-421. (opens in a new window)https://doi.org/10.1016/s2213-8587(24)00098-6

The Effects of Sleeve Gastrectomy on the Appetitive Domain of Taste Using the Progressive Ratio Task. Althukair, N. K., Abdeen, G. N., le Roux, C. W., Miras, A. D., & Alqahtani, A. R. (2024). Obes Surg, 34(4), 1168-1173. (opens in a new window)https://doi.org/10.1007/s11695-023-07035-x

Resmetirom and Metabolic Dysfunction-Associated Steatohepatitis: Perspectives on Multidisciplinary Management from Global Healthcare Professionals. Au, K., Zheng, M. H., Lee, W. J., Ghanem, O. M., Mahawar, K., Shabbir, A., le Roux, C. W., Targher, G., Byrne, C. D., Yilmaz, Y., Valenti, L., Sebastiani, G., Treeprasertsuk, S., Hui, H. X., Sakran, N., Neto, M. G., Kermansaravi, M., Kow, L., Seki, Y., Tham, K. W., Dang, J., Cohen, R. V., Stier, C., AlSabah, S., Oviedo, R. J., Chiappetta, S., Parmar, C., & Yang, W. (2024). Curr Obes Rep, 13(4), 818-830. (opens in a new window)https://doi.org/10.1007/s13679-024-00582-z

Changes in food preferences and ingestive behaviors after glucagon-like peptide-1 analog treatment: techniques and opportunities. Bettadapura, S., Dowling, K., Jablon, K., Al-Humadi, A. W., & le Roux, C. W. (2024). Int J Obes (Lond). (opens in a new window)https://doi.org/10.1038/s41366-024-01500-y

Exploring real-time functional magnetic resonance imaging neurofeedback in adolescents with disruptive behavior disorder and callous unemotional traits. Böttinger, B. W., Aggensteiner, P. M., Hohmann, S., Heintz, S., Ruf, M., Glennon, J., Holz, N. E., Banaschewski, T., Brandeis, D., & Baumeister, S. (2024). J Affect Disord, 345, 32-42. (opens in a new window)https://doi.org/10.1016/j.jad.2023.10.036

Determination of the Protein and Amino Acid Content of Fruit, Vegetables and Starchy Roots for Use in Inherited Metabolic Disorders. Boyle, F., Lynch, G., Reynolds, C. M., Green, A., Parr, G., Howard, C., Knerr, I., & Rice, J. (2024). Nutrients, 16(17). (opens in a new window)https://doi.org/10.3390/nu16172812

Real world use of tirzepatide in the treatment of type 2 diabetes in an Arab population. Buckley, A., Suliman, S., Allum, M., Mohammed, N., Lessan, N., le Roux, C. W., & Suliman, M. (2024). Diabetes Obes Metab, 26(8), 3381-3391. (opens in a new window)https://doi.org/10.1111/dom.15680

Genetic variants affecting mitochondrial function provide further insights for kidney disease. Cañadas-Garre, M., Baños-Jaime, B., Maqueda, J. J., Smyth, L. J., Cappa, R., Skelly, R., Hill, C., Brennan, E. P., Doyle, R., Godson, C., Maxwell, A. P., & McKnight, A. J. (2024). BMC Genomics, 25(1), 576. (opens in a new window)https://doi.org/10.1186/s12864-024-10449-1

Mitochondrial related variants associated with cardiovascular traits. Cañadas-Garre, M., Maqueda, J. J., Baños-Jaime, B., Hill, C., Skelly, R., Cappa, R., Brennan, E., Doyle, R., Godson, C., Maxwell, A. P., & McKnight, A. J. (2024). Front Physiol, 15, 1395371. (opens in a new window)https://doi.org/10.3389/fphys.2024.1395371

Obesity is South Africa's new HIV epidemic. Chandiwana, N., Venter, W., Manne-Goehler, J., Wade, A., Le Roux, C., Mbalati, N., Grimbeek, A., Kruger, P., Montsho, E., Zimela, Z., Yawa, A., Tshabalala, S., Rambau, N., Mpofu, N., Stevenson, S., McNulty, B., Ntusi, N., Pillay, Y., Dave, J., Murphy, A., Goldstein, S., Hfman, K., Mahomedy, S., Thomas, E., Mrara, B., Wing, J., Lubbe, J., Koto, Z., Conradie-Smit, M., Wharton, S., May, W., Marr, I., Kaplan, H., Forgan, M., Alexander, G., Turner, J., Fourie, V. R., Hellig, J., Banks, M., Ragsdale, K., Noeth, M., Mohamed, F., Myer, L., Lebina, L., Maswime, S., Moosa, Y., Thomas, S., Mbelle, M., Sinxadi, P., Bekker, L. G., Bhana, S., Fabian, J., Decloedt, E., Bayat, Z., Daya, R., Bobat, B., Storie, F., Goedecke, J., Kahn, K., Tollman, S., Mansfield, B., Siedner, M., Marconi, V., Mody, A., Mtshali, N., Geng, E., Srinivasa, S., Ali, M., Lalla-Edwards, S., Bentley, A., Wolvaardt, G., Hill, A., & Nel, J. (2024). S Afr Med J, 114(3), e1927. (opens in a new window)https://doi.org/10.7196/SAMJ.2024.v114i3.1927

Metabolic/Bariatric Surgery is Safe and Effective in People with Obesity, Type 2 Diabetes Mellitus and Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Cohen, R. V., Azevedo, M. A., Le Roux, C. W., Caldeon, L. P., Luque, A., Fayad, D. A., & Petry, T. B. Z. (2024). Obes Surg, 34(11), 4097-4105. (opens in a new window)https://doi.org/10.1007/s11695-024-07535-4

The role of nanosystems in the delivery of glucose-lowering drugs for the preemption and treatment of diabetes-associated atherosclerosis. Conroy, L. J., McCann, A., Zhang, N., & de Gaetano, M. (2024). Am J Physiol Cell Physiol, 326(5), C1398-c1409. (opens in a new window)https://doi.org/10.1152/ajpcell.00695.2023

Health Benefits Beyond the Scale: The Role of Diet and Nutrition During Weight Loss Programmes. Contreras, F., Al-Najim, W., & le Roux, C. W. (2024). Nutrients, 16(21). (opens in a new window)https://doi.org/10.3390/nu16213585

Subclassification of obesity for precision prediction of cardiometabolic diseases. Coral, D. E., Smit, F., Farzaneh, A., Gieswinkel, A., Tajes, J. F., Sparsø, T., Delfin, C., Bauvain, P., Wang, K., Temprosa, M., De Cock, D., Blanch, J., Fernández-Real, J. M., Ramos, R., Ikram, M. K., Gomez, M. F., Kavousi, M., Panova-Noeva, M., Wild, P. S., van der Kallen, C., Adriaens, M., van Greevenbroek, M., Arts, I., Le Roux, C., Ahmadizar, F., Frayling, T. M., Giordano, G. N., Pearson, E. R., & Franks, P. W. (2024). Nat Med. (opens in a new window)https://doi.org/10.1038/s41591-024-03299-7

Patient perspectives about treatment preferences for obesity with complications. Craig, H. C., Alsaeed, D., Norris, S., Holian, J., Kennedy, C., Feldman, A., & Le Roux, C. (2024). Obes Sci Pract, 10(1), e720. (opens in a new window)https://doi.org/10.1002/osp4.720

What influences patient decisions when selecting an obesity treatment? Craig, H. C., Walley, D., & le Roux, C. W. (2024). Obes Pillars, 12, 100123. (opens in a new window)https://doi.org/10.1016/j.obpill.2024.100123

Tirzepatide Reduces 24-Hour Ambulatory Blood Pressure in Adults With Body Mass Index ≥27 kg/m(2): SURMOUNT-1 Ambulatory Blood Pressure Monitoring Substudy. de Lemos, J. A., Linetzky, B., le Roux, C. W., Laffin, L. J., Vongpatanasin, W., Fan, L., Hemmingway, A., Ahmad, N. N., Bunck, M. C., & Stefanski, A. (2024). Hypertension, 81(4), e41-e43. (opens in a new window)https://doi.org/10.1161/hypertensionaha.123.22022

Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial. Deanfield, J., Verma, S., Scirica, B. M., Kahn, S. E., Emerson, S. S., Ryan, D., Lingvay, I., Colhoun, H. M., Plutzky, J., Kosiborod, M. N., Hovingh, G. K., Hardt-Lindberg, S., Frenkel, O., Weeke, P. E., Rasmussen, S., Goudev, A., Lang, C. C., Urina-Triana, M., Pietilä, M., & Lincoff, A. M. (2024). Lancet, 404(10454), 773-786. (opens in a new window)https://doi.org/10.1016/s0140-6736(24)01498-3

A Federated Database for Obesity Research: An IMI-SOPHIA Study. Delfin, C., Dragan, I., Kuznetsov, D., Tajes, J. F., Smit, F., Coral, D. E., Farzaneh, A., Haugg, A., Hungele, A., Niknejad, A., Hall, C., Jacobs, D., Marek, D., Fraser, D. P., Thuillier, D., Ahmadizar, F., Mehl, F., Pattou, F., Burdet, F., Hawkes, G., Arts, I. C. W., Blanch, J., Van Soest, J., Fernández-Real, J. M., Boehl, J., Fink, K., van Greevenbroek, M. M. J., Kavousi, M., Minten, M., Prinz, N., Ipsen, N., Franks, P. W., Ramos, R., Holl, R. W., Horban, S., Duarte-Salles, T., Tran, V. D. T., Raverdy, V., Leal, Y., Lenart, A., Pearson, E., Sparsø, T., Giordano, G. N., Ioannidis, V., Soh, K., Frayling, T. M., Le Roux, C. W., & Ibberson, M. (2024). Life (Basel), 14(2). (opens in a new window)https://doi.org/10.3390/life14020262

Tumour stemness and poor clinical outcomes in haemochromatosis patients with hepatocellular carcinoma. Di Capua, D. M., Shanahan, W., Bourke, M., Ramlaul, N., Appel, J., Canney, A., Docherty, N. G., McGrath, E., Ring, E., Jones, F., Boyle, M., McCormack, J., Gallagher, T., Hoti, E., Nolan, N., Ryan, J. D., Houlihan, D. D., & Fabre, A. (2024). J Clin Pathol, 77(10), 669-675. (opens in a new window)https://doi.org/10.1136/jcp-2022-208679

Reframing acute kidney injury as a pathophysiological continuum of disrupted renal excretory function. Docherty, N. G., Delles, C., & López-Hernández, F. J. (2024). Acta Physiol (Oxf), 240(8), e14181. (opens in a new window)https://doi.org/10.1111/apha.14181

The effects of saturated fat intake from dairy on CVD markers: the role of food matrices. Dunne, S., Gibney, E. R., McGillicuddy, F. C., & Feeney, E. L. (2024). Proc Nutr Soc, 1-9. (opens in a new window)https://doi.org/10.1017/s0029665124000132

Global barriers to decision makers for prioritizing interventions for obesity. Ehlers, L. H., Reinstrup, N. W., Olesen, R. H., Holm, J. C., McEwan, P., & Le Roux, C. W. (2024). Int J Obes (Lond). (opens in a new window)https://doi.org/10.1038/s41366-024-01650-z

Continuous glucose monitoring and low-glycaemic index diet in the management of postprandial hypoglycaemia after oesophagogastric cancer surgery. Fanning, M., Murphy, C. F., Elliott, J. A., Ravi, N., Docherty, N. G., le Roux, C. W., Donohoe, C. L., & Reynolds, J. V. (2024). Br J Surg, 111(1). (opens in a new window)https://doi.org/10.1093/bjs/znad371

Patient perspectives on personalised medicine for obesity: An IMI2 SOPHIA Study. Farrell, E., le Roux, C. W., Hollmann, E., Nadglowski, J., & McGillicuddy, D. (2024). Obes Res Clin Pract, 18(3), 216-221. (opens in a new window)https://doi.org/10.1016/j.orcp.2024.06.004

"What would be left of me?" Patient perspectives on the risks of obesity treatment: An innovative health initiative stratification of obesity phenotypes to optimise future obesity therapy (IMI2 SOPHIA) qualitative study. Farrell, E., Nadglowski, J., Hollmann, E., le Roux, C. W., & McGillicuddy, D. (2024). Obes Pillars, 12, 100129. (opens in a new window)https://doi.org/10.1016/j.obpill.2024.100129

Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group. Gao, Y., & Staginnus, M. (2024). Lancet Psychiatry, 11(8), 620-632. (opens in a new window)https://doi.org/10.1016/s2215-0366(24)00187-1

Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis. Gengatharan, J. M., Handzlik, M. K., Chih, Z. Y., Ruchhoeft, M. L., Secrest, P., Ashley, E. L., Green, C. R., Wallace, M., Gordts, P., & Metallo, C. M. (2024). Cell Metab. (opens in a new window)https://doi.org/10.1016/j.cmet.2024.10.016

The dual role of lipids in chronic kidney disease: Pathogenic culprits and therapeutic allies. Giardini, E., Moore, D., Sadlier, D., Godson, C., & Brennan, E. (2024). Atherosclerosis, 398, 118615. (opens in a new window)https://doi.org/10.1016/j.atherosclerosis.2024.118615

Long-term weight outcomes in patients treated with liraglutide 3.0 mg in real-world clinical practice. Grannell, A., Al-Najim, W., & le Roux, C. (2024). Clin Obes, 14(1), e12622. (opens in a new window)https://doi.org/10.1111/cob.12622

Obesity as a disease: a pressing need for alignment. Grannell, A., & le Roux, C. (2024). Int J Obes (Lond), 48(10), 1361-1362. (opens in a new window)https://doi.org/10.1038/s41366-024-01582-8

Impaired branched chain amino acid (BCAA) catabolism during adipocyte differentiation decreases glycolytic flux. Green, C. R., Alaeddine, L. M., Wessendorf-Rodriguez, K. A., Turner, R., Elmastas, M., Hover, J. D., Murphy, A. N., Ryden, M., Mejhert, N., Metallo, C. M., & Wallace, M. (2024). J Biol Chem, 108004. (opens in a new window)https://doi.org/10.1016/j.jbc.2024.108004

Therapeutic Options for Recurrence of Weight and Obesity Related Complications After Metabolic and Bariatric Surgery: An IFSO Position Statement. Haddad, A., Suter, M., Greve, J. W., Shikora, S., Prager, G., Dayyeh, B. A., Galvao, M., Grothe, K., Herrera, M., Kow, L., Le Roux, C., O'Kane, M., Parmar, C., Quadros, L. G., Ramos, A., Vidal, J., & Cohen, R. V. (2024). Obes Surg, 34(11), 3944-3962. (opens in a new window)https://doi.org/10.1007/s11695-024-07489-7

"Treated as second class citizens" - the lived experience of obesity-related stigma: an IMI2 SOPHIA study. Hollmann, E., Farrell, E., Le Roux, C., Nadglowski, J., & McGillicuddy, D. (2024). Int J Qual Stud Health Well-being, 19(1), 2344232. (opens in a new window)https://doi.org/10.1080/17482631.2024.2344232

Tirzepatide for Obesity Treatment and Diabetes Prevention. Jastreboff, A. M., le Roux, C. W., Stefanski, A., Aronne, L. J., Halpern, B., Wharton, S., Wilding, J. P. H., Perreault, L., Zhang, S., Battula, R., Bunck, M. C., Ahmad, N. N., & Jouravskaya, I. (2024). N Engl J Med. (opens in a new window)https://doi.org/10.1056/NEJMoa2410819

Developmentally programmed obesity: Is there a role for anti-inflammatory nutritional strategies? Kearns, M. L., & Reynolds, C. M. (2024a). Exp Physiol, 109(5), 633-646. (opens in a new window)https://doi.org/10.1113/ep091209

The impact of non-nutritive sweeteners on fertility, maternal and child health outcomes: a review of human and animal studies. Kearns, M. L., & Reynolds, C. M. (2024b). Proc Nutr Soc, 1-13. (opens in a new window)https://doi.org/10.1017/s0029665124000168

A Novel Role for FERM Domain-Containing Protein 3 (FRMD3) in CKD. Kennedy, C., Doyle, R., Gough, O., McEvoy, C., Anallen, S. M., Hughes, M., Sheng, X., Crifo, B., Andrews, D., Gaffney, A., Rodriguez, J., Kennedy, S., Dillon, E., Crean, D., Zhang, W., Yi, Z., Nair, V., Susztak, K., Hirschhorn, J., Florez, J., Groop, P. H., Sandholm, N., Kretzler, M., McKay, G. J., McKnight, A. J., Maxwell, A. P., Matallanas, D., Dorman, A., Martin, F., Conlon, P. J., Sadlier, D. M., Brennan, E., & Godson, C. (2024). Kidney360. (opens in a new window)https://doi.org/10.34067/kid.0000000602

Semaglutide and blood pressure: an individual patient data meta-analysis. Kennedy, C., Hayes, P., Cicero, A. F. G., Dobner, S., Le Roux, C. W., McEvoy, J. W., Zgaga, L., & Hennessy, M. (2024). Eur Heart J, 45(38), 4124-4134. (opens in a new window)https://doi.org/10.1093/eurheartj/ehae564

Survodutide for the Treatment of Obesity: Rationale and Design of the SYNCHRONIZE Cardiovascular Outcomes Trial. Kosiborod, M. N., Platz, E., Wharton, S., le Roux, C. W., Brueckmann, M., Ajaz Hussain, S., Unseld, A., Startseva, E., & Kaplan, L. M. (2024). JACC Heart Fail. (opens in a new window)https://doi.org/10.1016/j.jchf.2024.09.004

Protocol for the Growth and Maturation of hiPSC-Derived Kidney Organoids using Mechanically Defined Hydrogels. Krupa, I., Treacy, N. J., Clerkin, S., Davis, J. L., Miller, A. F., Saiani, A., Wychowaniec, J. K., Reynaud, E. G., Brougham, D. F., & Crean, J. (2024). Curr Protoc, 4(7), e1096. (opens in a new window)https://doi.org/10.1002/cpz1.1096

The emergence of obesity in type 1 diabetes. Kueh, M. T. W., Chew, N. W. S., Al-Ozairi, E., & le Roux, C. W. (2024). Int J Obes (Lond), 48(3), 289-301. (opens in a new window)https://doi.org/10.1038/s41366-023-01429-8

Oxyntomodulin physiology and its therapeutic development in obesity and associated complications. Kueh, M. T. W., Chong, M. C., Miras, A. D., & le Roux, C. W. (2024). J Physiol. (opens in a new window)https://doi.org/10.1113/jp287407

Topical Anti-Inflammatory Treatments for Eczema: A Cochrane Systematic Review and Network Meta-Analysis. Lax, S. J., Van Vogt, E., Candy, B., Steele, L., Reynolds, C., Stuart, B., Parker, R., Axon, E., Roberts, A., Doyle, M., Chu, D. K., Futamura, M., Santer, M., Williams, H. C., Cro, S., Drucker, A. M., & Boyle, R. J. (2024a). Clin Exp Allergy. (opens in a new window)https://doi.org/10.1111/cea.14556

Topical anti-inflammatory treatments for eczema: network meta-analysis. Lax, S. J., Van Vogt, E., Candy, B., Steele, L., Reynolds, C., Stuart, B., Parker, R., Axon, E., Roberts, A., Doyle, M., Chu, D. K., Futamura, M., Santer, M., Williams, H. C., Cro, S., Drucker, A. M., & Boyle, R. J. (2024b). Cochrane Database Syst Rev, 8(8), Cd015064. (opens in a new window)https://doi.org/10.1002/14651858.CD015064.pub2

Treatment of obesity with medications binding the glucagon-like peptide 1 receptor: what is the current state of play? Le Roux, C., & Mondoh, A. (2024). Expert Opin Pharmacother, 25(2), 131-138. (opens in a new window)https://doi.org/10.1080/14656566.2024.2311731

Anti-obesity treatment preferences of healthcare providers and people living with obesity: A survey-based study. Le Roux, C. W., Koroleva, A., Larsen, S., & Foot, E. (2024). Clin Obes, e12704. (opens in a new window)https://doi.org/10.1111/cob.12704

Glucagon and GLP-1 receptor dual agonist survodutide for obesity: a randomised, double-blind, placebo-controlled, dose-finding phase 2 trial. le Roux, C. W., Steen, O., Lucas, K. J., Startseva, E., Unseld, A., & Hennige, A. M. (2024). Lancet Diabetes Endocrinol, 12(3), 162-173. (opens in a new window)https://doi.org/10.1016/s2213-8587(23)00356-x

Serine and glycine physiology reversibly modulate retinal and peripheral nerve function. Lim, E. W., Fallon, R. J., Bates, C., Ideguchi, Y., Nagasaki, T., Handzlik, M. K., Joulia, E., Bonelli, R., Green, C. R., Ansell, B. R. E., Kitano, M., Polis, I., Roberts, A. J., Furuya, S., Allikmets, R., Wallace, M., Friedlander, M., Metallo, C. M., & Gantner, M. L. (2024). Cell Metab, 36(10), 2315-2328.e2316. (opens in a new window)https://doi.org/10.1016/j.cmet.2024.07.021

A Systems Nephrology Approach to Diabetic Kidney Disease Research and Practice. Martin, W. P., & Docherty, N. G. (2024). Nephron, 148(3), 127-136. (opens in a new window)https://doi.org/10.1159/000531823

The TNFSF12/TWEAK Modulates Colonic Inflammatory Fibroblast Differentiation and Promotes Fibroblast-Monocyte Interactions. Matellan, C., Kennedy, C., Santiago-Vela, M. I., Hochegger, J., MB, N. C., Wu, A., Shannon, C., Roche, H. M., Aceves, S. S., Godson, C., & Manresa, M. C. (2024). J Immunol, 212(12), 1958-1970. (opens in a new window)https://doi.org/10.4049/jimmunol.2300762

Obesity, Dietary Fats, and Gastrointestinal Cancer Risk-Potential Mechanisms Relating to Lipid Metabolism and Inflammation. Mitchelson, K. A. J., O'Connell, F., O'Sullivan, J., & Roche, H. M. (2024). Metabolites, 14(1). (opens in a new window)https://doi.org/10.3390/metabo14010042

Metabolic adaptation following gastric bypass surgery: results from a 2-year observational study. Naseer, F., Zhang, S. D., Miras, A. D., Redpath, T., Martin, M., Boyd, A., Spence, H., Pournaras, D. J., Bodnar, Z., Kerrigan, D., le Roux, C. W., Livingstone, M. B. E., & Price, R. K. (2024). Int J Obes (Lond), 48(11), 1577-1586. (opens in a new window)https://doi.org/10.1038/s41366-024-01585-5

Reduction of prevalence of patients meeting the criteria for metabolic syndrome with tirzepatide: a post hoc analysis from the SURPASS Clinical Trial Program. Nicholls, S. J., Tofé, S., le Roux, C. W., D'Alessio, D. A., Wiese, R. J., Pavo, I., Brown, K., Weerakkody, G. J., Zeytinoglu, M., & Romera, I. C. (2024). Cardiovasc Diabetol, 23(1), 63. (opens in a new window)https://doi.org/10.1186/s12933-024-02147-9

Weight loss with GLP-1 analogues in preparation for transplantation. O'Callaghan, M., Le Roux, C., Fabre, A., & McCarthy, C. (2024). BMJ Case Rep, 17(4). (opens in a new window)https://doi.org/10.1136/bcr-2023-256099

Long chain monomethyl branched-chain fatty acid levels in human milk vary with gestational weight gain. O'Sullivan, A., Brady, E., Lafferty, L., O'Shea, F., O'Regan, Z., Meurs, N., Baldini, M., Gengatharan, J., Metallo, C. M., & Wallace, M. (2024). Prostaglandins Leukot Essent Fatty Acids, 201, 102607. (opens in a new window)https://doi.org/10.1016/j.plefa.2024.102607

Expression Proteomics and Histone Analysis Reveal Extensive Chromatin Network Changes and a Role for Histone Tail Trimming during Cellular Differentiation. Oliviero, G., Wynne, K., Andrews, D., Crean, J., Kolch, W., & Cagney, G. (2024). Biomolecules, 14(7). (opens in a new window)https://doi.org/10.3390/biom14070747

Efficacy and safety of tirzepatide, GLP-1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta-analysis. Pan, X. H., Tan, B., Chin, Y. H., Lee, E. C. Z., Kong, G., Chong, B., Kueh, M., Khoo, C. M., Mehta, A., Majety, P., Grandhi, G. R., Dimitriadis, G. K., Foo, R., Chew, N. W. S., Le Roux, C. W., Mamas, M. A., & Chan, M. Y. (2024). Obesity (Silver Spring), 32(5), 840-856. (opens in a new window)https://doi.org/10.1002/oby.24002

Effectiveness of integrating a pragmatic pathway for prescribing liraglutide 3.0 mg in weight management services (STRIVE study): a multicentre, open-label, parallel-group, randomized controlled trial. Papamargaritis, D., Al-Najim, W., Lim, J. Z. M., Crane, J., Bodicoat, D. H., Barber, S., Lean, M., McGowan, B., O'Shea, D., Webb, D. R., Wilding, J. P. H., le Roux, C. W., & Davies, M. J. (2024). Lancet Reg Health Eur, 39, 100853. (opens in a new window)https://doi.org/10.1016/j.lanepe.2024.100853

New therapies for obesity. Papamargaritis, D., le Roux, C. W., Holst, J. J., & Davies, M. J. (2024). Cardiovasc Res, 119(18), 2825-2842. (opens in a new window)https://doi.org/10.1093/cvr/cvac176

Genetic Evidence of Causal Relation Between Intestinal Glucose Absorption and Early Postprandial Glucose Response: A Mendelian Randomization Study. Peschard, S., Raverdy, V., Bauvin, P., Goutchtat, R., Touche, V., Derudas, B., Gheeraert, C., Dubois-Chevalier, J., Caiazzo, R., Baud, G., Marciniak, C., Verkindt, H., Oukhouya Daoud, N., Le Roux, C. W., Lefebvre, P., Staels, B., Lestavel, S., & Pattou, F. (2024). Diabetes, 73(6), 983-992. (opens in a new window)https://doi.org/10.2337/db23-0805

Hyperglycemia and cognitive impairments anticipate the onset of an overt type 2 diabetes-like phenotype in TALLYHO/JngJ mice. Presta, M., Zoratto, F., Mulder, D., Ottomana, A. M., Pisa, E., Arias Vásquez, A., Slattery, D. A., Glennon, J. C., & Macrì, S. (2024). Psychoneuroendocrinology, 167, 107102. (opens in a new window)https://doi.org/10.1016/j.psyneuen.2024.107102

Hypothalamic control of body fat mass by food intake: The key to understanding why obesity should be treated as a disease. Purnell, J. Q., & le Roux, C. W. (2024). Diabetes Obes Metab, 26 Suppl 2, 3-12. (opens in a new window)https://doi.org/10.1111/dom.15478

Treatment with lipoxin A(4) improves influenza A infection outcome, induces macrophage reprogramming, anti-inflammatory and pro-resolutive responses. Rago, F., Melo, E. M., Miller, L. M., Duray, A. M., Batista Felix, F., Vago, J. P., de Faria Gonçalves, A. P., Angelo, A., Cassali, G. D., de Gaetano, M., Brennan, E., Owen, B., Guiry, P., Godson, C., Alcorn, J. F., & Teixeira, M. M. (2024). Inflamm Res, 73(11), 1903-1918. (opens in a new window)https://doi.org/10.1007/s00011-024-01939-9

Treatment with lipoxin A 4 improves influenza A infection outcome through macrophage reprogramming, anti-inflammatory and pro-resolutive responses. Rago, F., Melo, E. M., Miller, L. M., Duray, A. M., Felix, F. B., Vago, J. P., Gonçalves, A. P. F., Angelo, A., Cassali, G. D., Gaetano, M., Brennan, E., Owen, B., Guiry, P., Godson, C., Alcorn, J. F., & Teixeira, M. M. (2024). Res Sq. (opens in a new window)https://doi.org/10.21203/rs.3.rs-4491036/v1

Molecular landscape of the overlap between Alzheimer's disease and somatic insulin-related diseases. Ruisch, I. H., Widomska, J., De Witte, W., Mota, N. R., Fanelli, G., Van Gils, V., Jansen, W. J., Vos, S. J. B., Fóthi, A., Barta, C., Berkel, S., Alam, K. A., Martinez, A., Haavik, J., O'Leary, A., Slattery, D., Sullivan, M., Glennon, J., Buitelaar, J. K., Bralten, J., Franke, B., & Poelmans, G. (2024). Alzheimers Res Ther, 16(1), 239. (opens in a new window)https://doi.org/10.1186/s13195-024-01609-2

Bariatric surgery for spontaneous ovulation in women living with polycystic ovary syndrome: the BAMBINI multicentre, open-label, randomised controlled trial. Samarasinghe, S. N. S., Leca, B., Alabdulkader, S., Dimitriadis, G. K., Davasgaium, A., Thadani, P., Parry, K., Luli, M., O'Donnell, K., Johnson, B., Abbara, A., Seyfried, F., Morman, R., Ahmed, A. R., Hakky, S., Tsironis, C., Purkayastha, S., le Roux, C. W., Franks, S., Menon, V., Randeva, H., & Miras, A. D. (2024). Lancet, 403(10443), 2489-2503. (opens in a new window)https://doi.org/10.1016/s0140-6736(24)00538-5

Sex-dependent adipose glucose partitioning by the mitochondrial pyruvate carrier. Shannon, C. E., Bakewell, T., Fourcaudot, M. J., Ayala, I., Romero, G., Asmis, M., Lima, L. C. F., Wallace, M., & Norton, L. (2024). bioRxiv. (opens in a new window)https://doi.org/10.1101/2024.05.11.593540

The mitochondrial pyruvate carrier regulates adipose glucose partitioning in female mice. Shannon, C. E., Bakewell, T., Fourcaudot, M. J., Ayala, I., Smelter, A. A., Hinostroza, E. A., Romero, G., Asmis, M., Freitas Lima, L. C., Wallace, M., & Norton, L. (2024). Mol Metab, 88, 102005. (opens in a new window)https://doi.org/10.1016/j.molmet.2024.102005

The double burden: Navigating type 1 diabetes and obesity. Steenackers, N., Feldman, A. N., Mathieu, C., Rosen, J., Soderberg, J., Al-Ozairi, E., le Roux, C. W., & Van der Schueren, B. (2024). Clin Obes, 14(3), e12645. (opens in a new window)https://doi.org/10.1111/cob.12645

Harnessing the melanocortin system in the control of food intake and glucose homeostasis. Swan, P., Johnson, B., le Roux, C. W., & Miras, A. D. (2024). Peptides, 179, 171255. (opens in a new window)https://doi.org/10.1016/j.peptides.2024.171255

Induction of let-7d-5p miRNA modulates aortic smooth muscle inflammatory signaling and phenotypic switching. Vartak, T., Giardini, E., Kelly, D., Moran, B., Kennedy, C., Barry, M., Godson, C., & Brennan, E. (2024). Atherosclerosis, 395, 117573. (opens in a new window)https://doi.org/10.1016/j.atherosclerosis.2024.117573

Perspective: Peer Evaluation of Recommendations for CONSORT Guidelines for Randomized Controlled Trials in Nutrition. Weaver, C., Ahles, S., Murphy, K. J., Shyam, S., Cade, J., Plat, J., Schwingshackl, L., Roche, H. M., Lachat, C., Minihane, A. M., & Rigutto-Farebrother, J. (2024). Adv Nutr, 15(1), 100154. (opens in a new window)https://doi.org/10.1016/j.advnut.2023.100154

Survodutide for treatment of obesity: rationale and design of two randomized phase 3 clinical trials (SYNCHRONIZE™-1 and -2). Wharton, S., le Roux, C. W., Kosiborod, M. N., Platz, E., Brueckmann, M., Jastreboff, A. M., Ajaz Hussain, S., Pedersen, S. D., Borowska, L., Unseld, A., Kloer, I. M., & Kaplan, L. M. (2024). Obesity (Silver Spring). (opens in a new window)https://doi.org/10.1002/oby.24184

Recent advances in the treatment of patients with obesity and chronic kidney disease. Abdul Wahab, R., Cohen, R. V., & le Roux, C. W. (2023). Ann Med, 55(1), 2203517. (opens in a new window)https://doi.org/10.1080/07853890.2023.2203517

A review of the evidence on cardiovascular outcomes from obesity treatment. Abdul Wahab, R., & le Roux, C. W. (2023). Obes Pillars, 7, 100071. (opens in a new window)https://doi.org/10.1016/j.obpill.2023.100071

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. Acevedo, A., Jones, A. E., Danna, B. T., Turner, R., Montales, K. P., Benincá, C., Reue, K., Shirihai, O. S., Stiles, L., Wallace, M., Wang, Y., Bertholet, A. M., & Divakaruni, A. S. (2023). bioRxiv. (opens in a new window)https://doi.org/10.1101/2023.08.15.553413

Cell-Penetrating Milk-Derived Peptides with a Non-Inflammatory Profile. Agoni, C., Stavropoulos, I., Kirwan, A., Mysior, M. M., Holton, T., Kranjc, T., Simpson, J. C., Roche, H. M., & Shields, D. C. (2023). Molecules, 28(19). (opens in a new window)https://doi.org/10.3390/molecules28196999

Obesity Characteristics Are Poor Predictors of Genetic Mutations Associated with Obesity. Al-Humadi, A. W., Alabduljabbar, K., Alsaqaaby, M. S., Talaee, H., & le Roux, C. W. (2023). J Clin Med, 12(19). (opens in a new window)https://doi.org/10.3390/jcm12196396

Glucagon-like peptide-1 agonists combined with sodium-glucose cotransporter-2 inhibitors reduce weight in type 1 diabetes. Al-Ozairi, E., Irshad, M., Taghadom, E., Sojan, L., Al Kandari, J., Alroudhan, D., & le Roux, C. W. (2023). Obesity (Silver Spring), 31(3), 716-723. (opens in a new window)https://doi.org/10.1002/oby.23677

Food preferences after bariatric surgery: a review update. Alabduljabbar, K., Al-Najim, W., & le Roux, C. W. (2023). Intern Emerg Med, 18(2), 351-358. (opens in a new window)https://doi.org/10.1007/s11739-022-03157-9

Mechanisms of Action of Bariatric Surgery on Body Weight Regulation. Alabduljabbar, K., Bonanos, E., Miras, A. D., & le Roux, C. W. (2023). Gastroenterol Clin North Am, 52(4), 691-705. (opens in a new window)https://doi.org/10.1016/j.gtc.2023.08.002

Pharmacotherapy before and after bariatric surgery. Alabduljabbar, K., & le Roux, C. W. (2023). Metabolism, 148, 155692. (opens in a new window)https://doi.org/10.1016/j.metabol.2023.155692

Potassium channels in behavioral brain disorders. Molecular mechanisms and therapeutic potential: A narrative review. Alam, K. A., Svalastoga, P., Martinez, A., Glennon, J. C., & Haavik, J. (2023). Neurosci Biobehav Rev, 152, 105301. (opens in a new window)https://doi.org/10.1016/j.neubiorev.2023.105301

Weight loss to disrupt type 2 diabetes. Alsaqaaby, M. S., & le Roux, C. W. (2023). Diabetol Int, 14(3), 217-223. (opens in a new window)https://doi.org/10.1007/s13340-023-00626-0

Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis. Angelini, G., Panunzi, S., Castagneto-Gissey, L., Pellicanò, F., De Gaetano, A., Pompili, M., Riccardi, L., Garcovich, M., Raffaelli, M., Ciccoritti, L., Verrastro, O., Russo, M. F., Vecchio, F. M., Casella, G., Casella-Mariolo, J., Papa, L., Marini, P. L., Rubino, F., le Roux, C. W., Bornstein, S., & Mingrone, G. (2023). Gut, 72(2), 392-403. (opens in a new window)https://doi.org/10.1136/gutjnl-2022-327498

Microvascular complications of obesity and diabetes-Role of bariatric surgery. Bashir, B., Iqbal, Z., Adam, S., Ferdousi, M., Chick, W., Hussein, H. A., Syed, A. A., Le Roux, C. W., Cohen, R. V., Malik, R. A., & Soran, H. (2023). Obes Rev, 24(10), e13602. (opens in a new window)https://doi.org/10.1111/obr.13602

Exploring real-time functional magnetic resonance imaging neurofeedback in adolescents with disruptive behavior disorder and callous unemotional traits. Böttinger, B. W., Aggensteiner, P. M., Hohmann, S., Heintz, S., Ruf, M., Glennon, J., Holz, N. E., Banaschewski, T., Brandeis, D., & Baumeister, S. (2024). J Affect Disord, 345, 32-42. (opens in a new window)https://doi.org/10.1016/j.jad.2023.10.036

Maternal Intake of Either Fructose or the Artificial Sweetener Acesulfame-K Results in Differential and Sex-Specific Alterations in Markers of Skin Inflammation and Wound Healing Responsiveness in Mouse Offspring: A Pilot Study. Bridge-Comer, P. E., Vickers, M. H., Ferraro, S., Pagnon, A., Reynolds, C. M., & Sigaudo-Roussel, D. (2023). Nutrients, 15(11). (opens in a new window)https://doi.org/10.3390/nu15112534

Albuminuria-Related Genetic Biomarkers: Replication and Predictive Evaluation in Individuals with and without Diabetes from the UK Biobank. Cañadas-Garre, M., Kunzmann, A. T., Anderson, K., Brennan, E. P., Doyle, R., Patterson, C. C., Godson, C., Maxwell, A. P., & McKnight, A. J. (2023). Int J Mol Sci, 24(13). (opens in a new window)https://doi.org/10.3390/ijms241311209

Chronic Semaglutide Treatment in Rats Leads to Daily Excessive Concentration-Dependent Sucrose Intake. Cawthon, C. R., Blonde, G. D., Nisi, A. V., Bloomston, H. M., Krubitski, B., le Roux, C. W., & Spector, A. C. (2023). J Endocr Soc, 7(7), bvad074. (opens in a new window)https://doi.org/10.1210/jendso/bvad074

Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019. Chong, B., Jayabaskaran, J., Kong, G., Chan, Y. H., Chin, Y. H., Goh, R., Kannan, S., Ng, C. H., Loong, S., Kueh, M. T. W., Lin, C., Anand, V. V., Lee, E. C. Z., Chew, H. S. J., Tan, D. J. H., Chan, K. E., Wang, J. W., Muthiah, M., Dimitriadis, G. K., Hausenloy, D. J., Mehta, A. J., Foo, R., Lip, G., Chan, M. Y., Mamas, M. A., le Roux, C. W., & Chew, N. W. S. (2023). EClinicalMedicine, 57, 101850. (opens in a new window)https://doi.org/10.1016/j.eclinm.2023.101850

Laparoscopic adjustable gastric banding with liraglutide in adults with obesity and type 2 diabetes (GLIDE): a pilot randomised placebo controlled trial. Coelho, C., Dobbie, L. J., Crane, J., Douiri, A., Learoyd, A. E., Okolo, O., Panagiotopoulos, S., Pournaras, D. J., Ramar, S., Rubino, F., Singhal, R., le Roux, C. W., Taheri, S., & McGowan, B. (2023). Int J Obes (Lond), 47(11), 1132-1142. (opens in a new window)https://doi.org/10.1038/s41366-023-01368-4

Is Metabolic Surgery Having an Identity Crisis? Cohen, R. V., Lingay, I., Le Roux, C., & Sumithran, P. (2023). Obes Surg, 33(10), 3327-3329. (opens in a new window)https://doi.org/10.1007/s11695-023-06786-x

Development of synthetic lipoxin-A4 mimetics (sLXms): New avenues in the treatment of cardio-metabolic diseases. de Gaetano, M. (2023). Semin Immunol, 65, 101699. (opens in a new window)https://doi.org/10.1016/j.smim.2022.101699

Role of food matrix in modulating dairy fat induced changes in lipoprotein particle size distribution in a human intervention. Dunne, S., McGillicuddy, F. C., Gibney, E. R., & Feeney, E. L. (2023). Am J Clin Nutr, 117(1), 111-120. (opens in a new window)https://doi.org/10.1016/j.ajcnut.2022.10.002

iPSC-derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function. Eade, K. T., Ansell, B. R. E., Giles, S., Fallon, R., Harkins-Perry, S., Nagasaki, T., Tzaridis, S., Wallace, M., Mills, E. A., Farashi, S., Johnson, A., Sauer, L., Hart, B., Diaz-Rubio, M. E., Bahlo, M., Metallo, C., Allikmets, R., Gantner, M. L., Bernstein, P. S., & Friedlander, M. (2023). J Clin Invest, 133(9). (opens in a new window)https://doi.org/10.1172/jci163771

Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial. Garvey, W. T., Frias, J. P., Jastreboff, A. M., le Roux, C. W., Sattar, N., Aizenberg, D., Mao, H., Zhang, S., Ahmad, N. N., Bunck, M. C., Benabbad, I., & Zhang, X. M. (2023). Lancet, 402(10402), 613-626. (opens in a new window)https://doi.org/10.1016/s0140-6736(23)01200-x

Lipoxin Mimetics and the Resolution of Inflammation. Godson, C., Guiry, P., & Brennan, E. (2023). Annu Rev Pharmacol Toxicol, 63, 429-448. (opens in a new window)https://doi.org/10.1146/annurev-pharmtox-051921-085407

A consensus protocol for functional connectivity analysis in the rat brain. Grandjean, J., Desrosiers-Gregoire, G., Anckaerts, C., Angeles-Valdez, D., Ayad, F., Barrière, D. A., Blockx, I., Bortel, A., Broadwater, M., Cardoso, B. M., Célestine, M., Chavez-Negrete, J. E., Choi, S., Christiaen, E., Clavijo, P., Colon-Perez, L., Cramer, S., Daniele, T., Dempsey, E., Diao, Y., Doelemeyer, A., Dopfel, D., Dvořáková, L., Falfán-Melgoza, C., Fernandes, F. F., Fowler, C. F., Fuentes-Ibañez, A., Garin, C. M., Gelderman, E., Golden, C. E. M., Guo, C. C. G., Henckens, M., Hennessy, L. A., Herman, P., Hofwijks, N., Horien, C., Ionescu, T. M., Jones, J., Kaesser, J., Kim, E., Lambers, H., Lazari, A., Lee, S. H., Lillywhite, A., Liu, Y., Liu, Y. Y., López-Castro, A., López-Gil, X., Ma, Z., MacNicol, E., Madularu, D., Mandino, F., Marciano, S., McAuslan, M. J., McCunn, P., McIntosh, A., Meng, X., Meyer-Baese, L., Missault, S., Moro, F., Naessens, D. M. P., Nava-Gomez, L. J., Nonaka, H., Ortiz, J. J., Paasonen, J., Peeters, L. M., Pereira, M., Perez, P. D., Pompilus, M., Prior, M., Rakhmatullin, R., Reimann, H. M., Reinwald, J., Del Rio, R. T., Rivera-Olvera, A., Ruiz-Pérez, D., Russo, G., Rutten, T. J., Ryoke, R., Sack, M., Salvan, P., Sanganahalli, B. G., Schroeter, A., Seewoo, B. J., Selingue, E., Seuwen, A., Shi, B., Sirmpilatze, N., Smith, J. A. B., Smith, C., Sobczak, F., Stenroos, P. J., Straathof, M., Strobelt, S., Sumiyoshi, A., Takahashi, K., Torres-García, M. E., Tudela, R., van den Berg, M., van der Marel, K., van Hout, A. T. B., Vertullo, R., Vidal, B., Vrooman, R. M., Wang, V. X., Wank, I., Watson, D. J. G., Yin, T., Zhang, Y., Zurbruegg, S., Achard, S., Alcauter, S., Auer, D. P., Barbier, E. L., Baudewig, J., Beckmann, C. F., Beckmann, N., Becq, G., Blezer, E. L. A., Bolbos, R., Boretius, S., Bouvard, S., Budinger, E., Buxbaum, J. D., Cash, D., Chapman, V., Chuang, K. H., Ciobanu, L., Coolen, B. F., Dalley, J. W., Dhenain, M., Dijkhuizen, R. M., Esteban, O., Faber, C., Febo, M., Feindel, K. W., Forloni, G., Fouquet, J., Garza-Villarreal, E. A., Gass, N., Glennon, J. C., Gozzi, A., Gröhn, O., Harkin, A., Heerschap, A., Helluy, X., Herfert, K., Heuser, A., Homberg, J. R., Houwing, D. J., Hyder, F., Ielacqua, G. D., Jelescu, I. O., Johansen-Berg, H., Kaneko, G., Kawashima, R., Keilholz, S. D., Keliris, G. A., Kelly, C., Kerskens, C., Khokhar, J. Y., Kind, P. C., Langlois, J. B., Lerch, J. P., López-Hidalgo, M. A., Manahan-Vaughan, D., Marchand, F., Mars, R. B., Marsella, G., Micotti, E., Muñoz-Moreno, E., Near, J., Niendorf, T., Otte, W. M., Pais-Roldán, P., Pan, W. J., Prado-Alcalá, R. A., Quirarte, G. L., Rodger, J., Rosenow, T., Sampaio-Baptista, C., Sartorius, A., Sawiak, S. J., Scheenen, T. W. J., Shemesh, N., Shih, Y. I., Shmuel, A., Soria, G., Stoop, R., Thompson, G. J., Till, S. M., Todd, N., Van Der Linden, A., van der Toorn, A., van Tilborg, G. A. F., Vanhove, C., Veltien, A., Verhoye, M., Wachsmuth, L., Weber-Fahr, W., Wenk, P., Yu, X., Zerbi, V., Zhang, N., Zhang, B. B., Zimmer, L., Devenyi, G. A., Chakravarty, M. M., & Hess, A. (2023b). Nat Neurosci, 26(4), 673-681. (opens in a new window)https://doi.org/10.1038/s41593-023-01286-8

Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease. Green, C. R., Bonelli, R., Ansell, B. R. E., Tzaridis, S., Handzlik, M. K., McGregor, G. H., Hart, B., Trombley, J., Reilly, M. M., Bernstein, P. S., Egan, C., Fruttiger, M., Wallace, M., Bahlo, M., Friedlander, M., Metallo, C. M., & Gantner, M. L. (2023). Mol Metab, 72, 101716. (opens in a new window)https://doi.org/10.1016/j.molmet.2023.101716

Insulin-regulated serine and lipid metabolism drive peripheral neuropathy. Handzlik, M. K., Gengatharan, J. M., Frizzi, K. E., McGregor, G. H., Martino, C., Rahman, G., Gonzalez, A., Moreno, A. M., Green, C. R., Guernsey, L. S., Lin, T., Tseng, P., Ideguchi, Y., Fallon, R. J., Chaix, A., Panda, S., Mali, P., Wallace, M., Knight, R., Gantner, M. L., Calcutt, N. A., & Metallo, C. M. (2023). Nature, 614(7946), 118-124. (opens in a new window)https://doi.org/10.1038/s41586-022-05637-6

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Impact of Bariatric Surgery on Subtilisin/Kexin Type 9 (PCSK9) Gene Expression and Inflammation in the Adipose Tissue of Obese Diabetic Rats. Heald, A. H., Fachim, H. A., Bashir, B., Garside, B., Adam, S., Iqbal, Z., Syed, A. A., Donn, R., Le Roux, C. W., Abdelaal, M., White, J., & Soran, H. (2023). Int J Mol Sci, 24(23). (opens in a new window)https://doi.org/10.3390/ijms242316978

Effect of Bariatric Surgery on Serum Amyloid A Protein: a Systematic Review and Meta-analysis. Jamialahamdi, T., Mirhadi, E., Atkin, S. L., le Roux, C. W., Kroh, M., Almahmeed, W., Eid, A. H., & Sahebkar, A. (2023). Obes Surg, 33(11), 3602-3610. (opens in a new window)https://doi.org/10.1007/s11695-023-06830-w

Achieving consensus on the language of obesity: a modified Delphi study. Jepsen, C. H., Bowman-Busato, J., Allvin, T., Arthurs, N., Goossens, G. H., Govers, E., Jaghutriz, B. A., Mooney, V., Van der Schueren, B., & le Roux, C. W. (2023). EClinicalMedicine, 62, 102061. (opens in a new window)https://doi.org/10.1016/j.eclinm.2023.102061

Emotion recognition profiles in clusters of youth based on levels of callous-unemotional traits and reactive and proactive aggression. Kleine Deters, R., Naaijen, J., Holz, N. E., Banaschewski, T., Schulze, U. M. E., Sethi, A., Craig, M. C., Sagar-Ouriaghli, I., Santosh, P., Rosa, M., Castro-Fornieles, J., Penzol, M. J., Arango, C., Brandeis, D., Franke, B., Glennon, J. C., Buitelaar, J. K., Hoekstra, P. J., & Dietrich, A. (2023). Eur Child Adolesc Psychiatry, 32(12), 2415-2425. (opens in a new window)https://doi.org/10.1007/s00787-022-02079-3

Tirzepatide 10 and 15 mg compared with semaglutide 2.4 mg for the treatment of obesity: An indirect treatment comparison. le Roux, C. W., Hankosky, E. R., Wang, D., Malik, R., Yu, M., Hickey, A., Kan, H., Bunck, M. C., Stefanski, A., Garcia-Perez, L. E., & Wharton, S. (2023). Diabetes Obes Metab, 25(9), 2626-2633. (opens in a new window)https://doi.org/10.1111/dom.15148

Tirzepatide for the treatment of obesity: Rationale and design of the SURMOUNT clinical development program. le Roux, C. W., Zhang, S., Aronne, L. J., Kushner, R. F., Chao, A. M., Machineni, S., Dunn, J., Chigutsa, F. B., Ahmad, N. N., & Bunck, M. C. (2023). Obesity (Silver Spring), 31(1), 96-110. (opens in a new window)https://doi.org/10.1002/oby.23612

There is no magic bullet for obesity. Lingvay, I., Sumithran, P., le Roux, C. W., & Cohen, R. V. (2023). Lancet Diabetes Endocrinol, 11(8), 541. (opens in a new window)https://doi.org/10.1016/s2213-8587(23)00191-2

The efficacy of GLP-1RAs for the management of postprandial hypoglycemia following bariatric surgery: a systematic review. Llewellyn, D. C., Logan Ellis, H., Aylwin, S. J. B., Oštarijaš, E., Green, S., Sheridan, W., Chew, N. W. S., le Roux, C. W., Miras, A. D., Patel, A. G., Vincent, R. P., & Dimitriadis, G. K. (2023). Obesity (Silver Spring), 31(1), 20-30. (opens in a new window)https://doi.org/10.1002/oby.23600

The bi-directional relationship between sleep and inflammation in muscular dystrophies: A narrative review. Mahon, N., & Glennon, J. C. (2023). Neurosci Biobehav Rev, 150, 105116. (opens in a new window)https://doi.org/10.1016/j.neubiorev.2023.105116

Posing the rationale for synthetic lipoxin mimetics as an adjuvant treatment to gold standard atherosclerosis therapies. Millar, B., & de Gaetano, M. (2023). Front Pharmacol, 14, 1125858. (opens in a new window)https://doi.org/10.3389/fphar.2023.1125858

Systems biology approaches to inform precision nutrition. Mitchelson, K. A. J., MB, N. C., & Roche, H. M. (2023). Proc Nutr Soc, 82(2), 208-218. (opens in a new window)https://doi.org/10.1017/s0029665123002732

Prevalence and determinants of sarcopenia in community-dwelling older adults in Ireland. Murphy, C. H., McCarthy, S. N., McMorrow, A. M., Egan, B., McGowan, M. J., Rafferty, S., Corish, C. A., & Roche, H. M. (2023). Aging Clin Exp Res, 35(8), 1651-1660. (opens in a new window)https://doi.org/10.1007/s40520-023-02453-4

Nutrition strategies to counteract sarcopenia: a focus on protein, LC n-3 PUFA and precision nutrition. Murphy, C. H., McCarthy, S. N., & Roche, H. M. (2023). Proc Nutr Soc, 82(3), 419-431. (opens in a new window)https://doi.org/10.1017/s0029665123003555

Energy Metabolism, Metabolite, and Inflammatory Profiles in Human Ex Vivo Adipose Tissue Are Influenced by Obesity Status, Metabolic Dysfunction, and Treatment Regimes in Patients with Oesophageal Adenocarcinoma. O'Connell, F., Mylod, E., Donlon, N. E., Heeran, A. B., Butler, C., Bhardwaj, A., Ramjit, S., Durand, M., Lambe, G., Tansey, P., Welartne, I., Sheahan, K. P., Yin, X., Donohoe, C. L., Ravi, N., Dunne, M. R., Brennan, L., Reynolds, J. V., Roche, H. M., & O'Sullivan, J. (2023). Cancers (Basel), 15(6). (opens in a new window)https://doi.org/10.3390/cancers15061681

A systematic review of preclinical studies exploring the role of insulin signalling in executive function and memory. Ottomana, A. M., Presta, M., O'Leary, A., Sullivan, M., Pisa, E., Laviola, G., Glennon, J. C., Zoratto, F., Slattery, D. A., & Macrì, S. (2023). Neurosci Biobehav Rev, 155, 105435. (opens in a new window)https://doi.org/10.1016/j.neubiorev.2023.105435

Effect of Prolonged and Substantial Weight Loss on Incident Atrial Fibrillation: A Systematic Review and Meta-Analysis. Pontiroli, A. E., Centofanti, L., Le Roux, C. W., Magnani, S., Tagliabue, E., & Folli, F. (2023). Nutrients, 15(4). (opens in a new window)https://doi.org/10.3390/nu15040940

An Electrophysiological and Proteomic Analysis of the Effects of the Superoxide Dismutase Mimetic, MnTMPyP, on Synaptic Signalling Post-Ischemia in Isolated Rat Hippocampal Slices. Puzio, M., Moreton, N., Sullivan, M., Scaife, C., Glennon, J. C., & O'Connor, J. J. (2023). Antioxidants (Basel), 12(4). (opens in a new window)https://doi.org/10.3390/antiox12040792

The role of insulin/IGF1 signalling in neurodevelopmental and neuropsychiatric disorders - Evidence from human neuronal cell models. Réthelyi, J. M., Vincze, K., Schall, D., Glennon, J., & Berkel, S. (2023). Neurosci Biobehav Rev, 153, 105330. (opens in a new window)https://doi.org/10.1016/j.neubiorev.2023.105330

Don't sugar coat it: The independent and synergistic impacts of obesity and gestational diabetes on placental parameters. Reynolds, C. M. (2023). J Physiol, 601(7), 1155-1156. (opens in a new window)https://doi.org/10.1113/jp284407

Editorial: Women in nutrition and metabolism. Reynolds, C. M., Handjieva-Darlenska, T., & Nazare, J. A. (2023). Front Nutr, 10, 1181638. (opens in a new window)https://doi.org/10.3389/fnut.2023.1181638

Perspectives on the application of CONSORT guidelines to randomised controlled trials in nutrition. Rigutto-Farebrother, J., Ahles, S., Cade, J., Murphy, K. J., Plat, J., Schwingshackl, L., Roche, H. M., Shyam, S., Lachat, C., Minihane, A. M., & Weaver, C. (2023). Eur J Nutr, 62(5), 2319-2332. (opens in a new window)https://doi.org/10.1007/s00394-023-03137-5

Lancet Diabetes & Endocrinology Commission on the Definition and Diagnosis of Clinical Obesity. Rubino, F., Batterham, R. L., Koch, M., Mingrone, G., le Roux, C. W., Farooqi, I. S., Farpour-Lambert, N., Gregg, E. W., & Cummings, D. E. (2023). Lancet Diabetes Endocrinol, 11(4), 226-228. (opens in a new window)https://doi.org/10.1016/s2213-8587(23)00058-x

Development and validation of an interpretable machine learning-based calculator for predicting 5-year weight trajectories after bariatric surgery: a multinational retrospective cohort SOPHIA study. Saux, P., Bauvin, P., Raverdy, V., Teigny, J., Verkindt, H., Soumphonphakdy, T., Debert, M., Jacobs, A., Jacobs, D., Monpellier, V., Lee, P. C., Lim, C. H., Andersson-Assarsson, J. C., Carlsson, L., Svensson, P. A., Galtier, F., Dezfoulian, G., Moldovanu, M., Andrieux, S., Couster, J., Lepage, M., Lembo, E., Verrastro, O., Robert, M., Salminen, P., Mingrone, G., Peterli, R., Cohen, R. V., Zerrweck, C., Nocca, D., Le Roux, C. W., Caiazzo, R., Preux, P., & Pattou, F. (2023). Lancet Digit Health, 5(10), e692-e702. (opens in a new window)https://doi.org/10.1016/s2589-7500(23)00135-8

A potential osteogenic role for microRNA-181a-5p during palatogenesis. Schoen, C., Bloemen, M., Carels, C. E. L., Verhaegh, G. W., Van Rheden, R., Roa, L. A., Glennon, J. C., & Von den Hoff, J. W. (2023). Eur J Orthod, 45(5), 575-583. (opens in a new window)https://doi.org/10.1093/ejo/cjad037

Precision nutrition for targeting pathophysiology of cardiometabolic phenotypes. Shannon, C. E., MB, N. C., Mullin, S. M., Meehan, A., McGillicuddy, F. C., & Roche, H. M. (2023). Rev Endocr Metab Disord, 24(5), 921-936. (opens in a new window)https://doi.org/10.1007/s11154-023-09821-5

Insulin and disorders of behavioural flexibility. Sullivan, M., Fernandez-Aranda, F., Camacho-Barcia, L., Harkin, A., Macrì, S., Mora-Maltas, B., Jiménez-Murcia, S., O'Leary, A., Ottomana, A. M., Presta, M., Slattery, D., Scholtz, S., & Glennon, J. C. (2023). Neurosci Biobehav Rev, 150, 105169. (opens in a new window)https://doi.org/10.1016/j.neubiorev.2023.105169

Stratification of obesity phenotypes to optimize future therapy (SOPHIA). Tahrani, A. A., Panova-Noeva, M., Schloot, N. C., Hennige, A. M., Soderberg, J., Nadglowski, J., Tarasenko, L., Ahmad, N. N., Sleypen, B. S., Bravo, R., Al-Najim, W., & le Roux, C. W. (2023). Expert Rev Gastroenterol Hepatol, 17(10), 1031-1039. (opens in a new window)https://doi.org/10.1080/17474124.2023.2264783

Growth and differentiation of human induced pluripotent stem cell (hiPSC)-derived kidney organoids using fully synthetic peptide hydrogels. Treacy, N. J., Clerkin, S., Davis, J. L., Kennedy, C., Miller, A. F., Saiani, A., Wychowaniec, J. K., Brougham, D. F., & Crean, J. (2023). Bioact Mater, 21, 142-156. (opens in a new window)https://doi.org/10.1016/j.bioactmat.2022.08.003

Itaconate trims the fat. Turner, R., Cordes, T., & Wallace, M. (2023). Nat Metab, 5(6), 915-916. (opens in a new window)https://doi.org/10.1038/s42255-023-00819-6

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide. Turner, R., Mukherjee, R., Wallace, M., & Sanchez-Gurmaches, J. (2023). J Vis Exp(195). (opens in a new window)https://doi.org/10.3791/64219

MYC protein helps cancer to take its vitamins. Wallace, M. (2023). Nature, 624(7991), 258-260. (opens in a new window)https://doi.org/10.1038/d41586-023-03764-2

Different whole-brain functional connectivity correlates of reactive-proactive aggression and callous-unemotional traits in children and adolescents with disruptive behaviors. Werhahn, J. E., Smigielski, L., Sacu, S., Mohl, S., Willinger, D., Naaijen, J., Mulder, L. M., Glennon, J. C., Hoekstra, P. J., Dietrich, A., Deters, R. K., Aggensteiner, P. M., Holz, N. E., Baumeister, S., Banaschewski, T., Saam, M. C., Schulze, U. M. E., Lythgoe, D. J., Sethi, A., Craig, M., Mastroianni, M., Sagar-Ouriaghli, I., Santosh, P. J., Rosa, M., Bargallo, N., Castro-Fornieles, J., Arango, C., Penzol, M. J., Zwiers, M. P., Franke, B., Buitelaar, J. K., Walitza, S., & Brandeis, D. (2023). Neuroimage Clin, 40, 103542. (opens in a new window)https://doi.org/10.1016/j.nicl.2023.103542

Molecular Landscape of Tourette's Disorder. Widomska, J., De Witte, W., Buitelaar, J. K., Glennon, J. C., & Poelmans, G. (2023). Int J Mol Sci, 24(2). (opens in a new window)https://doi.org/10.3390/ijms24021428

The Relationship Between Percentage Weight Loss and World Health Organization-Five Wellbeing Index (WHO-5) in Patients Having Bariatric Surgery. Abdul Wahab, R., Al-Ruwaily, H., Coleman, T., Heneghan, H., Neff, K., le Roux, C. W., & Fallon, F. (2022). Obes Surg, 32(5), 1667-1672. (opens in a new window)https://doi.org/10.1007/s11695-022-06010-2

A review on the beneficial effects of bariatric surgery in the management of obesity. Abdul Wahab, R., & le Roux, C. W. (2022). Expert Rev Endocrinol Metab, 17(5), 435-446. (opens in a new window)https://doi.org/10.1080/17446651.2022.2110865

Mechanisms of Weight Loss After Obesity Surgery. Akalestou, E., Miras, A. D., Rutter, G. A., & le Roux, C. W. (2022). Endocr Rev, 43(1), 19-34. (opens in a new window)https://doi.org/10.1210/endrev/bnab022

The Impact Once-Weekly Semaglutide 2.4 mg Will Have on Clinical Practice: A Focus on the STEP Trials. Alabduljabbar, K., Al-Najim, W., & le Roux, C. W. (2022). Nutrients, 14(11). (opens in a new window)https://doi.org/10.3390/nu14112217

Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner. Aldhwayan, M. M., Al-Najim, W., Ruban, A., Glaysher, M. A., Johnson, B., Chhina, N., Dimitriadis, G. K., Prechtl, C. G., Johnson, N. A., Byrne, J. P., Goldstone, A. P., Teare, J. P., Le Roux, C. W., & Miras, A. D. (2022). Nutrients, 14(10). (opens in a new window)https://doi.org/10.3390/nu14102141

Renal insulin resistance in type 2 diabetes mellitus and progression of chronic kidney disease: potential pathogenic mechanisms. Alqallaf, A., Swan, P., & Docherty, N. G. (2022). Expert Rev Endocrinol Metab, 17(6), 523-532. (opens in a new window)https://doi.org/10.1080/17446651.2022.2131534

Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis. Angelini, G., Castagneto-Gissey, L., Salinari, S., Bertuzzi, A., Anello, D., Pradhan, M., Zschätzsch, M., Ritter, P., Le Roux, C. W., Rubino, F., Basso, N., Casella, G., Bornstein, S. R., Tremaroli, V., & Mingrone, G. (2022). Nat Commun, 13(1), 7715. (opens in a new window)https://doi.org/10.1038/s41467-022-35310-5

Oromotor and somatic taste reactivity during sucrose meals reveals internal state and stimulus palatability after gastric bypass in rats. Blonde, G. D., Mathes, C. M., Inui, T., Hamel, E. A., Price, R. K., Livingstone, M. B. E., Le Roux, C. W., & Spector, A. C. (2022). Am J Physiol Regul Integr Comp Physiol, 322(3), R204-r218. (opens in a new window)https://doi.org/10.1152/ajpregu.00285.2021

Effects of glucagon-like peptide-1 receptor agonists on histopathological and secondary biomarkers of non-alcoholic steatohepatitis: A systematic review and meta-analysis. Borodavkin, P., Sheridan, W., Coelho, C., Oštarijaš, E., Zaïr, Z. M., Miras, A. D., McGowan, B., le Roux, C. W., Vincent, R. P., & Dimitriadis, G. K. (2022). Diabetes Obes Metab, 24(2), 337-342. (opens in a new window)https://doi.org/10.1111/dom.14565

Obesity in Adults: A 2022 Adapted Clinical Practice Guideline for Ireland. Breen, C., O'Connell, J., Geoghegan, J., O'Shea, D., Birney, S., Tully, L., Gaynor, K., O'Kelly, M., O'Malley, G., O'Donovan, C., Lyons, O., Flynn, M., Allen, S., Arthurs, N., Browne, S., Byrne, M., Callaghan, S., Collins, C., Courtney, A., Crotty, M., Donohue, C., Donovan, C., Dunlevy, C., Duggan, D., Fearon, N., Finucane, F., Fitzgerald, I., Foy, S., Garvey, J., Gibson, I., Glynn, L., Gregg, E., Griffin, A., Harrington, J. M., Heary, C., Heneghan, H., Hogan, A., Hynes, M., Kearney, C., Kelly, D., Neff, K., le Roux, C. W., Manning, S., McAuliffe, F., Moore, S., Moran, N., Murphy, M., Murrin, C., O'Brien, S. M., O'Donnell, C., O'Dwyer, S., O'Grada, C., O'Malley, E., O'Reilly, O., O'Reilly, S., Porter, O., Roche, H. M., Rhynehart, A., Ryan, L., Seery, S., Soare, C., Shaamile, F., Walsh, A., Woods, C., Woods, C., & Yoder, R. (2022). Obes Facts, 15(6), 736-752. (opens in a new window)https://doi.org/10.1159/000527131

An innovative food system approach to diversifying protein intake: Protein-I: Shared Island sustainable healthy nutrition. Brennan, L., O'Gorman, A., Barth, S., Cadden, T., Dean, M., Doohan, F., Henchion, M., McIvor, R., McNulty, B., O'Donoghue, C., O'Reilly, S., Rafferty, J., Roche, H. M., Thorne, F., Wallace, M., Wright, D., & Nugent, A. P. (2022). Nutr Bull, 47(4), 516-523. (opens in a new window)https://doi.org/10.1111/nbu.12590

Maternal intake of fructose or artificial sweetener during pregnancy and lactation has persistent effects on metabolic and reproductive health of dams post-weaning. Bridge-Comer, P. E., Vickers, M. H., Morton-Jones, J., Spada, A., Rong, J., & Reynolds, C. M. (2022). J Dev Orig Health Dis, 13(5), 642-649. (opens in a new window)https://doi.org/10.1017/s2040174422000022

Gastric bypass versus best medical treatment for diabetic kidney disease: 5 years follow up of a single-centre open label randomised controlled trial. Cohen, R. V., Pereira, T. V., Aboud, C. M., Zanata Petry, T. B., Lopes Correa, J. L., Schiavon, C. A., Pompílio, C. E., Quirino Pechy, F. N., Calmon da Costa Silva, A. C., Cunha da Silveira, L. P., Paulo de Paris Caravatto, P., Halpern, H., de Lima Jacy Monteiro, F., da Costa Martins, B., Kuga, R., Sarian Palumbo, T. M., Friedman, A. N., & le Roux, C. W. (2022). EClinicalMedicine, 53, 101725. (opens in a new window)https://doi.org/10.1016/j.eclinm.2022.101725

Dose-Dependent Association of Inflammatory Cytokines with Carotid Atherosclerosis in Transient Ischaemic Attack: Implications for Clinical Trials. Coveney, S., McCabe, J. J., Murphy, S., Belton, O., Gray, C., Cassidy, T., Dolan, E., de Gaetano, M., Harbison, J., Horgan, G., Marnane, M., Merwick, A., Noone, I., Williams, D. J., & Kelly, P. J. (2022). Cerebrovasc Dis, 51(2), 178-187. (opens in a new window)https://doi.org/10.1159/000517739

The Concept of Healthy Behaviours in Obesity May Have Unintended Consequences. Craig, H. C., Doran, Z. M., & le Roux, C. W. (2022). Nutrients, 15(1). (opens in a new window)https://doi.org/10.3390/nu15010012

Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids. Davis, J. L., Kennedy, C., Clerkin, S., Treacy, N. J., Dodd, T., Moss, C., Murphy, A., Brazil, D. P., Cagney, G., Brougham, D. F., Murad, R., Finlay, D., Vuori, K., & Crean, J. (2022). Commun Biol, 5(1), 1301. (opens in a new window)https://doi.org/10.1038/s42003-022-04264-1

Peripheral Amino Acid Appearance Is Lower Following Plant Protein Fibre Products, Compared to Whey Protein and Fibre Ingestion, in Healthy Older Adults despite Optimised Amino Acid Profile. de Marco Castro, E., Valli, G., Buffière, C., Guillet, C., Mullen, B., Pratt, J., Horner, K., Naumann-Gola, S., Bader-Mittermaier, S., Paganini, M., De Vito, G., Roche, H. M., & Dardevet, D. (2022). Nutrients, 15(1). (opens in a new window)https://doi.org/10.3390/nu15010035

Trauma-induced human glucocorticoid receptor expression increases predict subsequent HPA-axis blunting in a prospective longitudinal design. de Voogd, L. D., Kampen, R. A., Kaldewaij, R., Zhang, W., Hashemi, M. M., Koch, S. B. J., Klumpers, F., Glennon, J. C., & Roelofs, K. (2022). Psychoneuroendocrinology, 146, 105909. (opens in a new window)https://doi.org/10.1016/j.psyneuen.2022.105909

Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function. Dyck, L., Prendeville, H., Raverdeau, M., Wilk, M. M., Loftus, R. M., Douglas, A., McCormack, J., Moran, B., Wilkinson, M., Mills, E. L., Doughty, M., Fabre, A., Heneghan, H., LeRoux, C., Hogan, A., Chouchani, E. T., O'Shea, D., Brennan, D., & Lynch, L. (2022b). J Exp Med, 219(3). (opens in a new window)https://doi.org/10.1084/jem.20210042

CRABP2 - A novel biomarker for high-risk endometrial cancer. Egan, D., Moran, B., Wilkinson, M., Pinyol, M., Guerra, E., Gatius, S., Matias-Guiu, X., Kolch, W., le Roux, C. W., & Brennan, D. J. (2022). Gynecol Oncol, 167(2), 314-322. (opens in a new window)https://doi.org/10.1016/j.ygyno.2022.09.020

A Fatty Diet Induces a Jejunal Ketogenesis Which Inhibits Local SGLT1-Based Glucose Transport via an Acetylation Mechanism-Results from a Randomized Cross-Over Study between Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy Volunteers. Elebring, E., Wallenius, V., Casselbrant, A., Docherty, N. G., Roux, C. W. L., Marschall, H. U., & Fändriks, L. (2022). Nutrients, 14(9). (opens in a new window)https://doi.org/10.3390/nu14091961

At home and at risk: The experiences of Irish adults living with obesity during the COVID-19 pandemic. Farrell, E., Hollmann, E., Roux, C. L., Nadglowski, J., & McGillicuddy, D. (2022). EClinicalMedicine, 51, 101568. (opens in a new window)https://doi.org/10.1016/j.eclinm.2022.101568

Say what you mean, mean what you say: The importance of language in the treatment of obesity. Fearon, N., Sudlow, A., le Roux, C. W., Pournaras, D. J., & Welbourn, R. (2022). Obesity (Silver Spring), 30(6), 1189-1196. (opens in a new window)https://doi.org/10.1002/oby.23446

Obstacles and Opportunities in Managing Coexisting Obesity and CKD: Report of a Scientific Workshop Cosponsored by the National Kidney Foundation and The Obesity Society. Friedman, A. N., Schauer, P. R., Beddhu, S., Kramer, H., le Roux, C. W., Purnell, J. Q., Sunwold, D., Tuttle, K. R., Jastreboff, A. M., & Kaplan, L. M. (2022a). Am J Kidney Dis, 80(6), 783-793. (opens in a new window)https://doi.org/10.1053/j.ajkd.2022.06.007

Obstacles and opportunities in managing coexisting obesity and CKD: Report of a scientific workshop cosponsored by the National Kidney Foundation and The Obesity Society. Friedman, A. N., Schauer, P. R., Beddhu, S., Kramer, H., le Roux, C. W., Purnell, J. Q., Sunwold, D., Tuttle, K. R., Jastreboff, A. M., & Kaplan, L. M. (2022b). Obesity (Silver Spring), 30(12), 2340-2350. (opens in a new window)https://doi.org/10.1002/oby.23599

Palmitic Acid and Oleic Acid Differently Modulate TLR2-Mediated Inflammatory Responses in Microglia and Macrophages. Howe, A. M., Burke, S., O'Reilly, M. E., McGillicuddy, F. C., & Costello, D. A. (2022). Mol Neurobiol, 59(4), 2348-2362. (opens in a new window)https://doi.org/10.1007/s12035-022-02756-z

Sodium salicylate rewires hepatic metabolic pathways in obesity and attenuates IL-1β secretion from adipose tissue: The implications for obesity-impaired reverse cholesterol transport. Kajani, S., Curley, S., O'Reilly, M. E., Yin, X., Dillon, E. T., Guo, W., Nilaweera, K. N., Brennan, L., Roche, H. M., & McGillicuddy, F. C. (2022). Mol Metab, 56, 101425. (opens in a new window)https://doi.org/10.1016/j.molmet.2021.101425

The Impact of Non-caloric Sweeteners on Male Fertility: A Systematic Review and Narrative Synthesis in Rodent Models. Kearns, M. L., MacAindriu, F., & Reynolds, C. M. (2022). Front Nutr, 9, 854074. (opens in a new window)https://doi.org/10.3389/fnut.2022.854074

Pharmacological profile of once-weekly injectable semaglutide for chronic weight management. Lau, D. C. W., Batterham, R. L., & le Roux, C. W. (2022). Expert Rev Clin Pharmacol, 15(3), 251-267. (opens in a new window)https://doi.org/10.1080/17512433.2022.2070473

The relationship between early weight loss and weight loss maintenance with naltrexone-bupropion therapy. le Roux, C. W., Fils-Aimé, N., Camacho, F., Gould, E., & Barakat, M. (2022). EClinicalMedicine, 49, 101436. (opens in a new window)https://doi.org/10.1016/j.eclinm.2022.101436

Research gaps and opportunities in precision nutrition: an NIH workshop report. Lee, B. Y., Ordovás, J. M., Parks, E. J., Anderson, C. A. M., Barabási, A. L., Clinton, S. K., de la Haye, K., Duffy, V. B., Franks, P. W., Ginexi, E. M., Hammond, K. J., Hanlon, E. C., Hittle, M., Ho, E., Horn, A. L., Isaacson, R. S., Mabry, P. L., Malone, S., Martin, C. K., Mattei, J., Meydani, S. N., Nelson, L. M., Neuhouser, M. L., Parent, B., Pronk, N. P., Roche, H. M., Saria, S., Scheer, F., Segal, E., Sevick, M. A., Spector, T. D., Van Horn, L., Varady, K. A., Voruganti, V. S., & Martinez, M. F. (2022). Am J Clin Nutr, 116(6), 1877-1900. (opens in a new window)https://doi.org/10.1093/ajcn/nqac237

Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation. Lingvay, I., Sumithran, P., Cohen, R. V., & le Roux, C. W. (2022). Lancet, 399(10322), 394-405. (opens in a new window)https://doi.org/10.1016/s0140-6736(21)01919-x

Food Intake Following Gastric Bypass Surgery: Patients Eat Less but Do Not Eat Differently. Livingstone, M. B. E., Redpath, T., Naseer, F., Boyd, A., Martin, M., Finlayson, G., Miras, A. D., Bodnar, Z., Kerrigan, D., Pournaras, D. J., le Roux, C. W., Spector, A. C., & Price, R. K. (2022). J Nutr, 152(11), 2319-2332. (opens in a new window)https://doi.org/10.1093/jn/nxac164

Obesity and cardiovascular disease: mechanistic insights and management strategies. A joint position paper by the World Heart Federation and World Obesity Federation. Lopez-Jimenez, F., Almahmeed, W., Bays, H., Cuevas, A., Di Angelantonio, E., le Roux, C. W., Sattar, N., Sun, M. C., Wittert, G., Pinto, F. J., & Wilding, J. P. H. (2022). Eur J Prev Cardiol, 29(17), 2218-2237. (opens in a new window)https://doi.org/10.1093/eurjpc/zwac187

Medications Activating Tubular Fatty Acid Oxidation Enhance the Protective Effects of Roux-en-Y Gastric Bypass Surgery in a Rat Model of Early Diabetic Kidney Disease. Martin, W. P., Chuah, Y. H. D., Abdelaal, M., Pedersen, A., Malmodin, D., Abrahamsson, S., Hutter, M., Godson, C., Brennan, E. P., Fändriks, L., le Roux, C. W., & Docherty, N. G. (2021). Front Endocrinol (Lausanne), 12, 757228. https://doi.org/10.3389/fendo.2021.757228

Obesity Is a Disease. Martin, W. P., & le Roux, C. W. (2022). Wellcome Trust–Funded Monographs and Book Chapters In D. Haslam, A. Malhotra, & M. S. Capehorn (Eds.), Bariatric Surgery in Clinical Practice (pp. 23-28). Springer Copyright 2022, Springer Nature Switzerland AG. (opens in a new window)https://doi.org/10.1007/978-3-030-83399-2_4

Urinary Metabolomic Changes Accompanying Albuminuria Remission following Gastric Bypass Surgery for Type 2 Diabetic Kidney Disease. Martin, W. P., Malmodin, D., Pedersen, A., Wallace, M., Fändriks, L., Aboud, C. M., Petry, T. B. Z., Cunha da Silveira, L. P., da Costa Silva, A. C. C., Cohen, R. V., le Roux, C. W., & Docherty, N. G. (2022). Metabolites, 12(2), 139. (opens in a new window)https://doi.org/10.3390/metabo12020139

Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats. Martin, W. P., Nair, M., Chuah, Y. H. D., Malmodin, D., Pedersen, A., Abrahamsson, S., Hutter, M., Abdelaal, M., Elliott, J. A., Fearon, N., Eckhardt, H., Godson, C., Brennan, E. P., Fändriks, L., le Roux, C. W., & Docherty, N. G. (2022). Clin Sci (Lond), 136(21), 1485-1511. (opens in a new window)https://doi.org/10.1042/cs20220205

Formation of hydrated PEG layers on magnetic iron oxide nanoflowers shows internal magnetisation dynamics and generates high in-vivo efficacy for MRI and magnetic hyperthermia. McKiernan, E. P., Moloney, C., Chaudhuri, T. R., Clerkin, S., Behan, K., Straubinger, R. M., Crean, J., & Brougham, D. F. (2022). Acta Biomater, 152, 393-405. (opens in a new window)https://doi.org/10.1016/j.actbio.2022.08.033

Erythritol and xylitol differentially impact brain networks involved in appetite regulation in healthy volunteers. Meyer-Gerspach, A. C., Wingrove, J. O., Beglinger, C., Rehfeld, J. F., Le Roux, C. W., Peterli, R., Dupont, P., O'Daly, O., Van Oudenhove, L., & Wölnerhanssen, B. K. (2022). Nutr Neurosci, 25(11), 2344-2358. (opens in a new window)https://doi.org/10.1080/1028415x.2021.1965787

Yeast β-Glucan Improves Insulin Sensitivity and Hepatic Lipid Metabolism in Mice Humanized with Obese Type 2 Diabetic Gut Microbiota. Mitchelson, K. A. J., Tran, T. T. T., Dillon, E. T., Vlckova, K., Harrison, S. M., Ntemiri, A., Cunningham, K., Gibson, I., Finucane, F. M., O'Connor, E. M., Roche, H. M., & O'Toole, P. W. (2022). Mol Nutr Food Res, 66(22), e2100819. (opens in a new window)https://doi.org/10.1002/mnfr.202100819

Deviant circadian rhythmicity, corticosterone variability and trait testosterone levels in aggressive mice. Mogavero, F., van Zwieten, K., Buitelaar, J. K., Glennon, J. C., & Henckens, M. (2022). Eur J Neurosci, 55(6), 1492-1503. (opens in a new window)https://doi.org/10.1111/ejn.15632

Interindividual variability in response to protein and fish oil supplementation in older adults: a randomized controlled trial. Murphy, C. H., Connolly, C., Flanagan, E. M., Mitchelson, K. A. J., de Marco Castro, E., Egan, B., Brennan, L., & Roche, H. M. (2022). J Cachexia Sarcopenia Muscle, 13(2), 872-883. (opens in a new window)https://doi.org/10.1002/jcsm.12936

Blood Transcriptome Profiling Links Immunity to Disease Severity in Myotonic Dystrophy Type 1 (DM1). Nieuwenhuis, S., Widomska, J., Blom, P., t Hoen, P. A. C., van Engelen, B. G. M., Glennon, J. C., & On Behalf Of The Optimistic, C. (2022). Int J Mol Sci, 23(6). (opens in a new window)https://doi.org/10.3390/ijms23063081

Synthesis and Biological Evaluation of Bicyclo[1.1.1]pentane-Containing Aromatic Lipoxin A(4) Analogues. Owen, B., de Gaetano, M., Gaffney, A., Godson, C., & Guiry, P. J. (2022). Org Lett, 24(32), 6049-6053. (opens in a new window)https://doi.org/10.1021/acs.orglett.2c02345

Changes in Glucose Metabolism and Glycemic Status With Once-Weekly Subcutaneous Semaglutide 2.4 mg Among Participants With Prediabetes in the STEP Program. Perreault, L., Davies, M., Frias, J. P., Laursen, P. N., Lingvay, I., Machineni, S., Varbo, A., Wilding, J. P. H., Wallenstein, S. O. R., & le Roux, C. W. (2022). Diabetes Care, 45(10), 2396-2405. (opens in a new window)https://doi.org/10.2337/dc21-1785

Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices. Perugini, J., Di Mercurio, E., Giuliani, A., Sabbatinelli, J., Bonfigli, A. R., Tortato, E., Severi, I., Cinti, S., Olivieri, F., le Roux, C. W., Gesuita, R., & Giordano, A. (2022). Sci Rep, 12(1), 8331. (opens in a new window)https://doi.org/10.1038/s41598-022-11942-x

A better understanding of the science and reality of obesity is urgently needed. Petre, T., Bauman, A., Sumithran, P., Sacks, G., Lobstein, T., Le Roux, C., Mullen, C., & Oldfield, B. (2022). Public Health Res Pract, 32(3). (opens in a new window)https://doi.org/10.17061/phrp3232220

Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35. Qin, C. X., Norling, L. V., Vecchio, E. A., Brennan, E. P., May, L. T., Wootten, D., Godson, C., Perretti, M., & Ritchie, R. H. (2022). Br J Pharmacol, 179(19), 4617-4639. (opens in a new window)https://doi.org/10.1111/bph.15919

Editorial: Maternal Diet and Offspring Health. Reynolds, C. M., & Vickers, M. H. (2022). Front Nutr, 9, 867661. (opens in a new window)https://doi.org/10.3389/fnut.2022.867661

Consensus report: Definition and interpretation of remission in type 2 diabetes. Riddle, M. C., Cefalu, W. T., Evans, P. H., Gerstein, H. C., Nauck, M. A., Oh, W. K., Rothberg, A. E., le Roux, C. W., Rubino, F., Schauer, P., Taylor, R., & Twenefour, D. (2022a). Diabet Med, 39(3), e14669. (opens in a new window)https://doi.org/10.1111/dme.14669

Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes. Riddle, M. C., Cefalu, W. T., Evans, P. H., Gerstein, H. C., Nauck, M. A., Oh, W. K., Rothberg, A. E., le Roux, C. W., Rubino, F., Schauer, P., Taylor, R., & Twenefour, D. (2022b). J Clin Endocrinol Metab, 107(1), 1-9. (opens in a new window)https://doi.org/10.1210/clinem/dgab585

The role of bariatric and metabolic surgery in the development, diagnosis, and treatment of endometrial cancer. Ross, R. C., Akinde, Y. M., Schauer, P. R., le Roux, C. W., Brennan, D., Jernigan, A. M., Bueter, M., & Albaugh, V. L. (2022). Front Surg, 9, 943544. (opens in a new window)https://doi.org/10.3389/fsurg.2022.943544

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease. Sandholm, N., Cole, J. B., Nair, V., Sheng, X., Liu, H., Ahlqvist, E., van Zuydam, N., Dahlström, E. H., Fermin, D., Smyth, L. J., Salem, R. M., Forsblom, C., Valo, E., Harjutsalo, V., Brennan, E. P., McKay, G. J., Andrews, D., Doyle, R., Looker, H. C., Nelson, R. G., Palmer, C., McKnight, A. J., Godson, C., Maxwell, A. P., Groop, L., McCarthy, M. I., Kretzler, M., Susztak, K., Hirschhorn, J. N., Florez, J. C., & Groop, P. H. (2022). Diabetologia, 65(9), 1495-1509. (opens in a new window)https://doi.org/10.1007/s00125-022-05735-0

Fish oil supplementation of rats fed a high fat diet during pregnancy improves offspring insulin sensitivity. Satokar, V. V., Vickers, M. H., Reynolds, C. M., Ponnampalam, A. P., Firth, E. C., Garg, M. L., Barrett, C. J., Cutfield, W. S., & Albert, B. B. (2022). Front Nutr, 9, 968443. (opens in a new window)https://doi.org/10.3389/fnut.2022.968443

Toxicity of oxidized fish oil in pregnancy: a dose-response study in rats. Satokar, V. V., Vickers, M. H., Reynolds, C. M., Ponnampalam, A. P., Firth, E. C., Garg, M. L., Bridge-Comer, P. E., Cutfield, W. S., & Albert, B. B. (2022). Am J Physiol Regul Integr Comp Physiol, 323(2), R244-r254. (opens in a new window)https://doi.org/10.1152/ajpregu.00042.2022

Multidimensional pain profiling in people living with obesity and attending weight management services: a protocol for a longitudinal cohort study. Smart, K. M., Hinwood, N. S., Dunlevy, C., Doody, C. M., Blake, C., Fullen, B. M., Le Roux, C. W., O'Connell, J., Gilsenan, C., Finucane, F. M., & O'Donoghue, G. (2022). BMJ Open, 12(12), e065188. (opens in a new window)https://doi.org/10.1136/bmjopen-2022-065188

Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease. Smyth, L. J., Dahlström, E. H., Syreeni, A., Kerr, K., Kilner, J., Doyle, R., Brennan, E., Nair, V., Fermin, D., Nelson, R. G., Looker, H. C., Wooster, C., Andrews, D., Anderson, K., McKay, G. J., Cole, J. B., Salem, R. M., Conlon, P. J., Kretzler, M., Hirschhorn, J. N., Sadlier, D., Godson, C., Florez, J. C., Forsblom, C., Maxwell, A. P., Groop, P. H., Sandholm, N., & McKnight, A. J. (2022). Nat Commun, 13(1), 7891. (opens in a new window)https://doi.org/10.1038/s41467-022-34963-6

Differential effects of RYGB surgery and best medical treatment for obesity-diabetes on intestinal and islet adaptations in obese-diabetic ZDSD rats. Sridhar, A., Khan, D., Abdelaal, M., Elliott, J. A., Naughton, V., Flatt, P. R., Le Roux, C. W., Docherty, N. G., & Moffett, C. R. (2022). PLoS One, 17(9), e0274788. (opens in a new window)https://doi.org/10.1371/journal.pone.0274788

Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior. Straathof, M., Blezer, E. L. A., Smeele, C. E., van Heijningen, C., van der Toorn, A., Buitelaar, J. K., Glennon, J. C., Otte, W. M., & Dijkhuizen, R. M. (2022). Psychopharmacology (Berl), 239(8), 2457-2470. (opens in a new window)https://doi.org/10.1007/s00213-022-06139-z

Carbon Dioxide Sensing by Immune Cells Occurs through Carbonic Anhydrase 2-Dependent Changes in Intracellular pH. Strowitzki, M. J., Nelson, R., Garcia, M. P., Tuffs, C., Bleul, M. B., Fitzsimons, S., Navas, J., Uzieliene, I., Ritter, A. S., Phelan, D., Kierans, S. J., Blanco, A., Bernotiene, E., Belton, O., Schneider, M., Cummins, E. P., & Taylor, C. T. (2022). J Immunol, 208(10), 2363-2375. (opens in a new window)https://doi.org/10.4049/jimmunol.2100665

Medication following bariatric surgery for type 2 diabetes mellitus (BY-PLUS) study: rationale and design of a randomised controlled study. Sudlow, A., Miras, A. D., Cohen, R. V., Kahal, H., Townley, J., Heneghan, H., Le Roux, C., & Pournaras, D. J. (2022). BMJ Open, 12(7), e054313. (opens in a new window)https://doi.org/10.1136/bmjopen-2021-054313

Surgery for Weight Loss or Health Gain? Sudlow, A. C., & le Roux, C. W. (2022). Diabetes Care, 45(7), 1498-1499. (opens in a new window)https://doi.org/10.2337/dci22-0011

Understanding the risk of developing weight-related complications associated with different body mass index categories: a systematic review. Taieb, A. B., Roberts, E., Luckevich, M., Larsen, S., le Roux, C. W., de Freitas, P. G., & Wolfert, D. (2022). Diabetol Metab Syndr, 14(1), 186. (opens in a new window)https://doi.org/10.1186/s13098-022-00952-4

Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis. Tielbeek, J. J., Uffelmann, E., Williams, B. S., Colodro-Conde, L., Gagnon, É., Mallard, T. T., Levitt, B. E., Jansen, P. R., Johansson, A., Sallis, H. M., Pistis, G., Saunders, G. R. B., Allegrini, A. G., Rimfeld, K., Konte, B., Klein, M., Hartmann, A. M., Salvatore, J. E., Nolte, I. M., Demontis, D., Malmberg, A. L. K., Burt, S. A., Savage, J. E., Sugden, K., Poulton, R., Harris, K. M., Vrieze, S., McGue, M., Iacono, W. G., Mota, N. R., Mill, J., Viana, J. F., Mitchell, B. L., Morosoli, J. J., Andlauer, T. F. M., Ouellet-Morin, I., Tremblay, R. E., Côté, S. M., Gouin, J. P., Brendgen, M. R., Dionne, G., Vitaro, F., Lupton, M. K., Martin, N. G., Castelao, E., Räikkönen, K., Eriksson, J. G., Lahti, J., Hartman, C. A., Oldehinkel, A. J., Snieder, H., Liu, H., Preisig, M., Whipp, A., Vuoksimaa, E., Lu, Y., Jern, P., Rujescu, D., Giegling, I., Palviainen, T., Kaprio, J., Harden, K. P., Munafò, M. R., Morneau-Vaillancourt, G., Plomin, R., Viding, E., Boutwell, B. B., Aliev, F., Dick, D. M., Popma, A., Faraone, S. V., Børglum, A. D., Medland, S. E., Franke, B., Boivin, M., Pingault, J. B., Glennon, J. C., Barnes, J. C., Fisher, S. E., Moffitt, T. E., Caspi, A., Polderman, T. J. C., & Posthuma, D. (2022). Mol Psychiatry, 27(11), 4453-4463. (opens in a new window)https://doi.org/10.1038/s41380-022-01793-3

Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood. van Cruchten, R. T. P., van As, D., Glennon, J. C., van Engelen, B. G. M., & t Hoen, P. A. C. (2022). BMC Med, 20(1), 395. (opens in a new window)https://doi.org/10.1186/s12916-022-02591-y

Pivotal Response Treatment with and without robot-assistance for children with autism: a randomized controlled trial. van den Berk-Smeekens, I., de Korte, M. W. P., van Dongen-Boomsma, M., Oosterling, I. J., den Boer, J. C., Barakova, E. I., Lourens, T., Glennon, J. C., Staal, W. G., & Buitelaar, J. K. (2022). Eur Child Adolesc Psychiatry, 31(12), 1871-1883. (opens in a new window)https://doi.org/10.1007/s00787-021-01804-8

Decoding microRNA drivers in atherosclerosis. Vartak, T., Kumaresan, S., & Brennan, E. (2022). Biosci Rep, 42(7). (opens in a new window)https://doi.org/10.1042/bsr20212355

Metabolic balance-a masterclass in mass action. Wallace, M. (2022). Nat Metab, 4(1), 17-18. (opens in a new window)https://doi.org/10.1038/s42255-021-00522-4

Once-Weekly Semaglutide in Adolescents with Obesity. Weghuber, D., Barrett, T., Barrientos-Pérez, M., Gies, I., Hesse, D., Jeppesen, O. K., Kelly, A. S., Mastrandrea, L. D., Sørrig, R., & Arslanian, S. (2022). N Engl J Med, 387(24), 2245-2257. (opens in a new window)https://doi.org/10.1056/NEJMoa2208601

HDL particle size is increased and HDL-cholesterol efflux is enhanced in type 1 diabetes: a cross-sectional study. Ahmed, M. O., Byrne, R. E., Pazderska, A., Segurado, R., Guo, W., Gunness, A., Frizelle, I., Sherlock, M., Ahmed, K. S., McGowan, A., Moore, K., Boran, G., McGillicuddy, F. C., & Gibney, J. (2021). Diabetologia, 64(3), 656-667. (opens in a new window)https://doi.org/10.1007/s00125-020-05320-3

Clinical Impact of Liraglutide as a Treatment of Obesity. Alruwaili, H., Dehestani, B., & le Roux, C. W. (2021). Clin Pharmacol, 13, 53-60. (opens in a new window)https://doi.org/10.2147/cpaa.S276085

Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases. Andrews, D., & Godson, C. (2021). Biochim Biophys Acta Mol Cell Biol Lipids, 1866(8), 158940. (opens in a new window)https://doi.org/10.1016/j.bbalip.2021.158940

Neuropsychological Characterization of Aggressive Behavior in Children and Adolescents with CD/ODD and Effects of Single Doses of Medications: The Protocol of the Matrics_WP6-1 Study. Balia, C., Carucci, S., Milone, A., Romaniello, R., Valente, E., Donno, F., Montesanto, A., Brovedani, P., Masi, G., Glennon, J. C., Coghill, D., Zuddas, A., & The Matrics, C. (2021). Brain Sci, 11(12). (opens in a new window)https://doi.org/10.3390/brainsci11121639

The Impact of Protein Supplementation on Appetite and Energy Intake in Healthy Older Adults: A Systematic Review with Meta-Analysis. Ben-Harchache, S., Roche, H. M., Corish, C. A., & Horner, K. M. (2021). Adv Nutr, 12(2), 490-502. (opens in a new window)https://doi.org/10.1093/advances/nmaa115

Editorial: Personalized Nutrition. Blaak, E. E., Roche, H. M., & Afman, L. A. (2021). Front Nutr, 8, 669307. (opens in a new window)https://doi.org/10.3389/fnut.2021.669307

Meal Patterns and Food Choices of Female Rats Fed a Cafeteria-Style Diet Are Altered by Gastric Bypass Surgery. Blonde, G. D., Price, R. K., le Roux, C. W., & Spector, A. C. (2021). Nutrients, 13(11). (opens in a new window)https://doi.org/10.3390/nu13113856

Dipeptidyl peptidase-4 activity, lipopolysaccharide, C-reactive protein, glucose metabolism, and gut peptides 3 months after bariatric surgery. Braga, T. G., Graças Coelho de Souza, M. D., Menezes, M., Nogueira Neto, J. F., Dellatorre-Teixeira, L., Bouskela, E., le Roux, C. W., & Kraemer-Aguiar, L. G. (2021). Surg Obes Relat Dis, 17(1), 113-120. (opens in a new window)https://doi.org/10.1016/j.soard.2020.08.030

Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function. Brennan, E., Kantharidis, P., Cooper, M. E., & Godson, C. (2021). Nat Rev Nephrol, 17(11), 725-739. (opens in a new window)https://doi.org/10.1038/s41581-021-00454-y

Impact of Maternal Intake of Artificial Sweetener, Acesulfame-K, on Metabolic and Reproductive Health Outcomes in Male and Female Mouse Offspring. Bridge-Comer, P. E., Vickers, M. H., Morton-Jones, J., Spada, A., Rong, J., & Reynolds, C. M. (2021). Front Nutr, 8, 745203. (opens in a new window)https://doi.org/10.3389/fnut.2021.745203

Potential gut-brain mechanisms behind adverse mental health outcomes of bariatric surgery. Brown, R. M., Guerrero-Hreins, E., Brown, W. A., le Roux, C. W., & Sumithran, P. (2021). Nat Rev Endocrinol, 17(9), 549-559. (opens in a new window)https://doi.org/10.1038/s41574-021-00520-2

Discriminating Dietary Responses by Combining Transcriptomics and Metabolomics Data in Nutrition Intervention Studies. Burton-Pimentel, K. J., Pimentel, G., Hughes, M., Michielsen, C. C., Fatima, A., Vionnet, N., Afman, L. A., Roche, H. M., Brennan, L., Ibberson, M., & Vergères, G. (2021). Mol Nutr Food Res, 65(4), e2000647. (opens in a new window)https://doi.org/10.1002/mnfr.202000647

The Impact of CKD on Perioperative Risk and Mortality after Bariatric Surgery. Carvalho Silveira, F., Martin, W. P., Maranga, G., le Roux, C. W., & Ren-Fielding, C. J. (2021). Kidney360, 2(2), 236-244. (opens in a new window)https://doi.org/10.34067/kid.0004832020

The Role of Bariatric Surgery in Prevention of Kidney Disease Progression in Moderately Obese Patients With Type 2 Diabetes-Reply. Cohen, R. V., Pereira, T. V., & le Roux, C. W. (2021). JAMA Surg, 156(2), 206-207. (opens in a new window)https://doi.org/10.1001/jamasurg.2020.5192

Renoprotective Effects of the Combination of Empagliflozin and Liraglutide Compared With Roux-en-Y Gastric Bypass in Early-Stage Diabetic Kidney Disease: A Post Hoc Analysis of the Microvascular Outcomes after Metabolic Surgery (MOMS) Randomized Controlled Clinical Trial. Cohen, R. V., Petry, T. B. Z., Miras, A. D., Aboud, C. M., Johnson, B., Dos Santos, T. M., & le Roux, C. W. (2021). Diabetes Care, 44(10), e177-179. (opens in a new window)https://doi.org/10.2337/dc21-1192

Metabolic Inflammation in Obesity-At the Crossroads between Fatty Acid and Cholesterol Metabolism. Curley, S., Gall, J., Byrne, R., Yvan-Charvet, L., & McGillicuddy, F. C. (2021). Mol Nutr Food Res, 65(1), e1900482. (opens in a new window)https://doi.org/10.1002/mnfr.201900482

Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A(4) Mimetics (QNX-sLXms). de Gaetano, M., Tighe, C., Gahan, K., Zanetti, A., Chen, J., Newson, J., Cacace, A., Marai, M., Gaffney, A., Brennan, E., Kantharidis, P., Cooper, M. E., Leroy, X., Perretti, M., Gilroy, D., Godson, C., & Guiry, P. J. (2021). J Med Chem, 64(13), 9193-9216. (opens in a new window)https://doi.org/10.1021/acs.jmedchem.1c00403

UK Nutrition Research Partnership (NRP) workshop: Forum on advancing dietary intake assessment. de la Hunty, A., Buttriss, J., Draper, J., Roche, H., Levey, G., Florescu, A., Penfold, N., & Frost, G. (2021). Nutr Bull, 46(2), 228-237. (opens in a new window)https://doi.org/10.1111/nbu.12501

β-1,3/1,6-Glucans and Immunity: State of the Art and Future Directions. De Marco Castro, E., Calder, P. C., & Roche, H. M. (2021). Mol Nutr Food Res, 65(1), e1901071. (opens in a new window)https://doi.org/10.1002/mnfr.201901071

Targeting the Gut Microbiota to Improve Dietary Protein Efficacy to Mitigate Sarcopenia. de Marco Castro, E., Murphy, C. H., & Roche, H. M. (2021). Front Nutr, 8, 656730. (opens in a new window)https://doi.org/10.3389/fnut.2021.656730

Amylin as a Future Obesity Treatment. Dehestani, B., Stratford, N. R., & le Roux, C. W. (2021). J Obes Metab Syndr, 30(4), 320-325. (opens in a new window)https://doi.org/10.7570/jomes21071

Haemodynamic frailty - A risk factor for acute kidney injury in the elderly. Docherty, N. G., Delles, C., D'Haese, P., Layton, A. T., Martínez-Salgado, C., Vervaet, B. A., & López-Hernández, F. J. (2021). Ageing Res Rev, 70, 101408. (opens in a new window)https://doi.org/10.1016/j.arr.2021.101408

The lived experience of people with obesity: study protocol for a systematic review and synthesis of qualitative studies. Farrell, E., Bustillo, M., le Roux, C. W., Nadglowski, J., Hollmann, E., & McGillicuddy, D. (2021). Syst Rev, 10(1), 181. (opens in a new window)https://doi.org/10.1186/s13643-021-01706-5

The lived experience of patients with obesity: A systematic review and qualitative synthesis. Farrell, E., Hollmann, E., le Roux, C. W., Bustillo, M., Nadglowski, J., & McGillicuddy, D. (2021). Obes Rev, 22(12), e13334. (opens in a new window)https://doi.org/10.1111/obr.13334

Mechanisms of intermittent hypoxia-mediated macrophage activation - potential therapeutic targets for obstructive sleep apnoea. Fitzpatrick, S. F., King, A. D., O'Donnell, C., Roche, H. M., & Ryan, S. (2021). J Sleep Res, 30(3), e13202. (opens in a new window)https://doi.org/10.1111/jsr.13202

Management of Obesity in Adults with CKD. Friedman, A. N., Kaplan, L. M., le Roux, C. W., & Schauer, P. R. (2021). J Am Soc Nephrol, 32(4), 777-790. (opens in a new window)https://doi.org/10.1681/asn.2020101472

Preterm human milk: associations between perinatal factors and hormone concentrations throughout lactation. Galante, L., Reynolds, C. M., Milan, A. M., Alexander, T., Bloomfield, F. H., Cameron-Smith, D., Pundir, S., & Vickers, M. H. (2021). Pediatr Res, 89(6), 1461-1469. (opens in a new window)https://doi.org/10.1038/s41390-020-1069-1

Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner. Galante, L., Reynolds, C. M., Milan, A. M., Alexander, T., Bloomfield, F. H., Jiang, Y., Asadi, S., Muelbert, M., Cameron-Smith, D., Pundir, S., & Vickers, M. H. (2021). Front Nutr, 8, 641227. (opens in a new window)https://doi.org/10.3389/fnut.2021.641227

Therapeutic potential of the FPR2/ALX agonist AT-01-KG in the resolution of articular inflammation. Galvão, I., Melo, E. M., de Oliveira, V. L. S., Vago, J. P., Queiroz-Junior, C., de Gaetano, M., Brennan, E., Gahan, K., Guiry, P. J., Godson, C., & Teixeira, M. M. (2021). Pharmacol Res, 165, 105445. (opens in a new window)https://doi.org/10.1016/j.phrs.2021.105445

Obesity, COVID-19 and innate immunometabolism. Gleeson, L. E., Roche, H. M., & Sheedy, F. J. (2021). Br J Nutr, 125(6), 628-632. (opens in a new window)https://doi.org/10.1017/s0007114520003529

Obesity and responsibility: Is it time to rethink agency? Grannell, A., Fallon, F., Al-Najim, W., & le Roux, C. (2021). Obes Rev, 22(8), e13270. (opens in a new window)https://doi.org/10.1111/obr.13270

Exploring patient beliefs and perceptions regarding obesity as a disease, obesity causation and treatment. Grannell, A., Fallon, F., Pournaras, D., & le Roux, C. W. (2021). Ir J Med Sci, 190(1), 163-168. (opens in a new window)https://doi.org/10.1007/s11845-020-02319-y

"You Are Always at War With Yourself" The Perceptions and Beliefs of People With Obesity Regarding Obesity as a Disease. Grannell, A., le Roux, C. W., & McGillicuddy, D. (2021). Qual Health Res, 31(13), 2470-2485. (opens in a new window)https://doi.org/10.1177/10497323211040767

Liraglutide Does Not Adversely Impact Fat-Free Mass Loss. Grannell, A., Martin, W. P., Dehestani, B., Al-Najim, W., Murphy, J. C., & le Roux, C. W. (2021). Obesity (Silver Spring), 29(3), 529-534. (opens in a new window)https://doi.org/10.1002/oby.23098

Opposing Immune-Metabolic Signature in Visceral Versus Subcutaneous Adipose Tissue in Patients with Adenocarcinoma of the Oesophagus and the Oesophagogastric Junction. Heeran, A. B., McCready, J., Dunne, M. R., Donlon, N. E., Nugent, T. S., Bhardwaj, A., Mitchelson, K. A. J., Buckley, A. M., Ravi, N., Roche, H. M., Reynolds, J. V., Lynam-Lennon, N., & O'Sullivan, J. (2021). Metabolites, 11(11). (opens in a new window)https://doi.org/10.3390/metabo11110768

Assessment of baseline rates of functional and absolute iron deficiency in bariatric surgery candidates: a retrospective study. Hegarty, C., Breen, C., Fearon, N. M., Heneghan, H. M., Docherty, N. G., & Gletsu Miller, N. (2021). Surg Obes Relat Dis, 17(12), 2009-2014. (opens in a new window)https://doi.org/10.1016/j.soard.2021.09.005

Structural Degradation in Midcingulate Cortex Is Associated with Pathological Aggression in Mice. Heukelum, S. V., Geers, F. E., Tulva, K., van Dulm, S., Beckmann, C. F., Buitelaar, J. K., Glennon, J. C., Vogt, B. A., Havenith, M. N., & França, A. S. C. (2021). Brain Sci, 11(7). (opens in a new window)https://doi.org/10.3390/brainsci11070868

A Comparison of Total Food Intake at a Personalised Buffet in People with Obesity, before and 24 Months after Roux-en-Y-Gastric Bypass Surgery. Kapoor, N., Al Najim, W., Menezes, C., Price, R. K., O'Boyle, C., Bodnar, Z., Spector, A. C., Docherty, N. G., & le Roux, C. W. (2021). Nutrients, 13(11). (opens in a new window)https://doi.org/10.3390/nu13113873

Longitudinal Assessment of Strength, Functional Capacity, Oropharyngeal Function, and Quality of Life in Oculopharyngeal Muscular Dystrophy. Kroon, R., Kalf, J. G., de Swart, B. J. M., van der Sluijs, B. M., Glennon, J. C., Raz, V., van Engelen, B. G., & Horlings, C. G. C. (2021). Neurology, 97(15), e1475-e1483. (opens in a new window)https://doi.org/10.1212/wnl.0000000000012640

Endoscopic Evaluation and Management of Late Complications After Bariatric Surgery: a Narrative Review. Kumbhari, V., le Roux, C. W., & Cohen, R. V. (2021). Obes Surg, 31(10), 4624-4633. (opens in a new window)https://doi.org/10.1007/s11695-021-05603-7

Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial. Lau, D. C. W., Erichsen, L., Francisco, A. M., Satylganova, A., le Roux, C. W., McGowan, B., Pedersen, S. D., Pietiläinen, K. H., Rubino, D., & Batterham, R. L. (2021). Lancet, 398(10317), 2160-2172. (opens in a new window)https://doi.org/10.1016/s0140-6736(21)01751-7

COVID-19 alters thinking and management in metabolic diseases. le Roux, C. W. (2021). Nat Rev Endocrinol, 17(2), 71-72. (opens in a new window)https://doi.org/10.1038/s41574-020-00449-y

Obesity, cardiovascular risk and healthcare resource utilization in the UK. le Roux, C. W., Hartvig, N. V., Haase, C. L., Nordsborg, R. B., Olsen, A. H., & Satylganova, A. (2021). Eur J Prev Cardiol, 28(11), 1235-1241. (opens in a new window)https://doi.org/10.1177/2047487320925639

Bariatric Surgery: There Is a Room for Improvement to Reduce Mortality in Patients with Type 2 Diabetes. le Roux, C. W., Ottosson, J., Näslund, E., Cohen, R. V., Stenberg, E., Sundbom, M., & Näslund, I. (2021). Obes Surg, 31(1), 461-463. (opens in a new window)https://doi.org/10.1007/s11695-020-04934-1

Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential. Maciuszek, M., Cacace, A., Brennan, E., Godson, C., & Chapman, T. M. (2021). Eur J Med Chem, 213, 113167. (opens in a new window)https://doi.org/10.1016/j.ejmech.2021.113167

Medications Activating Tubular Fatty Acid Oxidation Enhance the Protective Effects of Roux-en-Y Gastric Bypass Surgery in a Rat Model of Early Diabetic Kidney Disease. Martin, W. P., Chuah, Y. H. D., Abdelaal, M., Pedersen, A., Malmodin, D., Abrahamsson, S., Hutter, M., Godson, C., Brennan, E. P., Fändriks, L., le Roux, C. W., & Docherty, N. G. (2021). Front Endocrinol (Lausanne), 12, 757228. (opens in a new window)https://doi.org/10.3389/fendo.2021.757228

Protocol for a preclinical systematic review and meta-analysis of pharmacological targeting of peroxisome proliferator-activated receptors in experimental renal injury. Martin, W. P., Chuah, Y. H. D., Conroy, E., Reynolds, A. L., Judge, C., López-Hernández, F. J., le Roux, C. W., & Docherty, N. G. (2021). BMJ Open Sci, 5(1), e100240. (opens in a new window)https://doi.org/10.1136/bmjos-2021-100240

Impact of Metabolic Surgery on Renal Injury in Pre-Clinical Models of Diabetic Kidney Disease. Martin, W. P., le Roux, C. W., & Docherty, N. G. (2021). Nephron, 145(6), 585-594. (opens in a new window)https://doi.org/10.1159/000511790

Metabolic surgery versus conventional therapy in type 2 diabetes. Miras, A. D., & le Roux, C. W. (2021). Lancet, 397(10271), 256-257. (opens in a new window)https://doi.org/10.1016/s0140-6736(21)00129-x

The altered enteroendocrine reportoire following roux-en-Y-gastric bypass as an effector of weight loss and improved glycaemic control. Moffett, R. C., Docherty, N. G., & le Roux, C. W. (2021). Appetite, 156, 104807. (opens in a new window)https://doi.org/10.1016/j.appet.2020.104807

Bariatric surgery in the treatment of patients with obesity and type 1 diabetes: A retrospective study of clinical data. Mohammed, N., Buckley, A., Elsheikh, M., Allum, M., Suliman, S., Al Hadad, M., le Roux, C. W., Lessan, N., & Suliman, M. (2021). Diabetes Obes Metab, 23(7), 1562-1570. (opens in a new window)https://doi.org/10.1111/dom.14369

Spatiotemporally Resolved Heat Dissipation in 3D Patterned Magnetically Responsive Hydrogels. Monks, P., Wychowaniec, J. K., McKiernan, E., Clerkin, S., Crean, J., Rodriguez, B. J., Reynaud, E. G., Heise, A., & Brougham, D. F. (2021). Small, 17(5), e2004452. (opens in a new window)https://doi.org/10.1002/smll.202004452

Early experience with a nutrition and survivorship clinic in esophageal cancer. Murphy, C. F., Fanning, M., Raftery, N., Elliott, J. A., Docherty, N. G., Donohoe, C. L., Ravi, N., le Roux, C. W., & Reynolds, J. V. (2021). Dis Esophagus, 34(2). (opens in a new window)https://doi.org/10.1093/dote/doaa061

A Pilot Study of Gut-Brain Signaling After Octreotide Therapy for Unintentional Weight Loss After Esophagectomy. Murphy, C. F., Stratford, N., Docherty, N. G., Moran, B., Elliott, J. A., Healy, M. L., McMorrow, J. P., Ravi, N., Goldstone, A. P., Reynolds, J. V., & le Roux, C. W. (2021). J Clin Endocrinol Metab, 106(1), e204-e216. (opens in a new window)https://doi.org/10.1210/clinem/dgaa697

Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial. Murphy, C. H., Flanagan, E. M., De Vito, G., Susta, D., Mitchelson, K. A. J., de Marco Castro, E., Senden, J. M. G., Goessens, J. P. B., Mikłosz, A., Chabowski, A., Segurado, R., Corish, C. A., McCarthy, S. N., Egan, B., van Loon, L. J. C., & Roche, H. M. (2021). Am J Clin Nutr, 113(6), 1411-1427. (opens in a new window)https://doi.org/10.1093/ajcn/nqaa449

Primum non nocere-first, do no harm with bariatric surgery. Neff, K. J., & le Roux, C. W. (2021). Lancet Diabetes Endocrinol, 9(8), 476-477. (opens in a new window)https://doi.org/10.1016/s2213-8587(21)00143-1

Factors Associated with Favorable Changes in Food Preferences After Bariatric Surgery. Nielsen, M. S., Christensen, B. J., Ritz, C., Holm, L., Lunn, S., Tækker, L., Schmidt, J. B., Bredie, W. L. P., Wewer Albrechtsen, N. J., Holst, J. J., Hilbert, A., le Roux, C. W., & Sjödin, A. (2021). Obes Surg, 31(8), 3514-3524. (opens in a new window)https://doi.org/10.1007/s11695-021-05374-1

Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity. Oggero, S., de Gaetano, M., Marcone, S., Fitzsimons, S., Pinto, A. L., Ikramova, D., Barry, M., Burke, D., Montero-Melendez, T., Cooper, D., Burgoyne, T., Belton, O., Norling, L. V., Brennan, E. P., Godson, C., & Perretti, M. (2021). J Extracell Vesicles, 10(6), 12084. (opens in a new window)https://doi.org/10.1002/jev2.12084

Metabolic syndrome is associated with prostate enlargement: a systematic review, meta-analysis, and meta-regression on patients with lower urinary tract symptom factors. Omran, A., Leca, B. M., Oštarijaš, E., Graham, N., Da Silva, A. S., Zaïr, Z. M., Miras, A. D., le Roux, C. W., Vincent, R. P., Cardozo, L., & Dimitriadis, G. K. (2021). Ther Adv Endocrinol Metab, 12, 20420188211066210. (opens in a new window)https://doi.org/10.1177/20420188211066210

Do Gut Hormones Contribute to Weight Loss and Glycaemic Outcomes after Bariatric Surgery? Papamargaritis, D., & le Roux, C. W. (2021). Nutrients, 13(3). (opens in a new window)https://doi.org/10.3390/nu13030762

Understanding the mechanism of how bariatric surgery works is a key component to build the evidence base. Pournaras, D. J., & le Roux, C. W. (2021). Surg Obes Relat Dis, 17(7), 1391-1392. (opens in a new window)https://doi.org/10.1016/j.soard.2021.04.003

Microbiome Transfer Partly Overrides Lack of IL-1RI Signaling to Alter Hepatic but not Adipose Tissue Phenotype and Lipid Handling following a High-Fat Diet Challenge. Ralston, J. C., Mitchelson, K. A. J., Lynch, G. M., Tran, T. T. T., Wang, H., Strain, C. R., Lenighan, Y. M., Kennedy, E. B., Stanton, C., McGillicuddy, F. C., Su, Q., O'Toole, P. W., & Roche, H. M. (2021). Mol Nutr Food Res, 65(1), e2000202. (opens in a new window)https://doi.org/10.1002/mnfr.202000202

Evaluation of the impact of gastric bypass surgery on eating behaviour using objective methodologies under residential conditions: Rationale and study protocol. Redpath, T., Naseer, F., Price, R. K., Boyd, A., Martin, M., le Roux, C. W., Spector, A. C., & Livingstone, M. B. E. (2021). Contemp Clin Trials Commun, 24, 100846. (opens in a new window)https://doi.org/10.1016/j.conctc.2021.100846

Methodological issues in assessing change in dietary intake and appetite following gastric bypass surgery: A systematic review. Redpath, T. L., Livingstone, M. B. E., Dunne, A. A., Boyd, A., le Roux, C. W., Spector, A. C., & Price, R. K. (2021). Obes Rev, 22(6), e13202. (opens in a new window)https://doi.org/10.1111/obr.13202

Consensus report: definition and interpretation of remission in type 2 diabetes. Riddle, M. C., Cefalu, W. T., Evans, P. H., Gerstein, H. C., Nauck, M. A., Oh, W. K., Rothberg, A. E., le Roux, C. W., Rubino, F., Schauer, P., Taylor, R., & Twenefour, D. (2021a). Diabetologia, 64(11), 2359-2366. (opens in a new window)https://doi.org/10.1007/s00125-021-05542-z

Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes. Riddle, M. C., Cefalu, W. T., Evans, P. H., Gerstein, H. C., Nauck, M. A., Oh, W. K., Rothberg, A. E., le Roux, C. W., Rubino, F., Schauer, P., Taylor, R., & Twenefour, D. (2021b). Diabetes Care, 44(10), 2438-2444. (opens in a new window)https://doi.org/10.2337/dci21-0034

Metabolism and Inflammation: New Synergies and Insights. Roche, H. M. (2021a). Mol Nutr Food Res, 65(1), e2000994. (opens in a new window)https://doi.org/10.1002/mnfr.202000994

Postprandial metabolism and inflammation-a comprehensive model to advance Precision Nutrition? Lessons learned from the Personalised REsponses to DIetary Composition Trial (PREDICT study). Roche, H. M. (2021b). Am J Clin Nutr, 114(3), 841-842. (opens in a new window)https://doi.org/10.1093/ajcn/nqab200

Weight loss with bariatric surgery or behaviour modification and the impact on female obesity-related urine incontinence: A comprehensive systematic review and meta-analysis. Sheridan, W., Da Silva, A. S., Leca, B. M., Ostarijas, E., Patel, A. G., Aylwin, S. J., Vincent, R. P., Panagiotopoulos, S., El-Hasani, S., le Roux, C. W., Miras, A. D., Cardozo, L., & Dimitriadis, G. K. (2021). Clin Obes, 11(4), e12450. (opens in a new window)https://doi.org/10.1111/cob.12450

The Role of Mitochondria in Optic Atrophy With Autosomal Inheritance. Strachan, E. L., Mac White-Begg, D., Crean, J., Reynolds, A. L., Kennedy, B. N., & O'Sullivan, N. C. (2021). Front Neurosci, 15, 784987. (opens in a new window)https://doi.org/10.3389/fnins.2021.784987

Improving gastric balloons to treat obesity. Sudlow, A., & le Roux, C. W. (2021). Lancet, 398(10315), 1940-1941. (opens in a new window)https://doi.org/10.1016/s0140-6736(21)02505-8

Nothing Ventured, Nothing Gained: Does This Apply to Obesity in Young People? Sudlow, A. C., & le Roux, C. W. (2021a). J Am Coll Surg, 233(6), 664-665. (opens in a new window)https://doi.org/10.1016/j.jamcollsurg.2021.08.683

Why are adolescents with obesity and diabetes not having bariatric surgery earlier? Sudlow, A. C., & le Roux, C. W. (2021b). Surg Obes Relat Dis, 17(1), 33-35. (opens in a new window)https://doi.org/10.1016/j.soard.2020.10.005

The role of staging laparoscopy in complex bariatric surgery. Sudlow, A. C., le Roux, C. W., Hardwick, R., & Pournaras, D. J. (2021). Clin Obes, 11(4), e12460. (opens in a new window)https://doi.org/10.1111/cob.12460

An Exploration of the Patient Lived Experience of Remission and Relapse of Type 2 Diabetes Following Bariatric Surgery. Sudlow, A. C., Pournaras, D. J., Heneghan, H., Bodnar, Z., le Roux, C. W., & McGillicuddy, D. (2021). Obes Surg, 31(9), 3919-3925. (opens in a new window)https://doi.org/10.1007/s11695-021-05514-7

Clinical Outcome Evaluations and CBT Response Prediction in Myotonic Dystrophy. van As, D., Okkersen, K., Bassez, G., Schoser, B., Lochmüller, H., Glennon, J. C., Knoop, H., van Engelen, B. G. M., & t Hoen, P. A. C. (2021). J Neuromuscul Dis, 8(6), 1031-1046. (opens in a new window)https://doi.org/10.3233/jnd-210634

A central role for anterior cingulate cortex in the control of pathological aggression. van Heukelum, S., Tulva, K., Geers, F. E., van Dulm, S., Ruisch, I. H., Mill, J., Viana, J. F., Beckmann, C. F., Buitelaar, J. K., Poelmans, G., Glennon, J. C., Vogt, B. A., Havenith, M. N., & França, A. S. C. (2021). Curr Biol, 31(11), 2321-2333.e2325. (opens in a new window)https://doi.org/10.1016/j.cub.2021.03.062

Therapeutic potential of pro-resolving mediators in diabetic kidney disease. Vartak, T., Godson, C., & Brennan, E. (2021). Adv Drug Deliv Rev, 178, 113965. (opens in a new window)https://doi.org/10.1016/j.addr.2021.113965

Glycemic Control and Metabolic Adaptation in Response to High-Fat versus High-Carbohydrate Diets-Data from a Randomized Cross-Over Study in Healthy Subjects. Wallenius, V., Elebring, E., Casselbrant, A., Laurenius, A., le Roux, C. W., Docherty, N. G., Biörserud, C., Björnfot, N., Engström, M., Marschall, H. U., & Fändriks, L. (2021). Nutrients, 13(10). (opens in a new window)https://doi.org/10.3390/nu13103322

Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study. Wölnerhanssen, B. K., Drewe, J., Verbeure, W., le Roux, C. W., Dellatorre-Teixeira, L., Rehfeld, J. F., Holst, J. J., Hartmann, B., Tack, J., Peterli, R., Beglinger, C., & Meyer-Gerspach, A. C. (2021). Diabetes Obes Metab, 23(6), 1311-1321. (opens in a new window)https://doi.org/10.1111/dom.14342

Continuous Glucose Monitoring of Glycemic Variability During Fasting Post-Sleeve Gastrectomy. Al-Ozairi, E., El Samad, A., Al Kandari, J., Taghadom, E., Adam, S., le Roux, C., & Syed, A. A. (2020). Obes Surg, 30(10), 3721-3729. (opens in a new window)https://doi.org/10.1007/s11695-020-04505-4

OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions. Alligier, M., Barrès, R., Blaak, E. E., Boirie, Y., Bouwman, J., Brunault, P., Campbell, K., Clément, K., Farooqi, I. S., Farpour-Lambert, N. J., Frühbeck, G., Goossens, G. H., Hager, J., Halford, J. C. G., Hauner, H., Jacobi, D., Julia, C., Langin, D., Natali, A., Neovius, M., Oppert, J. M., Pagotto, U., Palmeira, A. L., Roche, H., Rydén, M., Scheen, A. J., Simon, C., Sorensen, T. I. A., Tappy, L., Yki-Järvinen, H., Ziegler, O., & Laville, M. (2020). Obes Facts, 13(1), 1-28. (opens in a new window)https://doi.org/10.1159/000505342

Diagnostic utility of genetic testing in patients undergoing renal biopsy. Benson, K. A., Murray, S. L., Doyle, R., Doyle, B., Dorman, A. M., Sadlier, D., Brennan, E., Large, M., Cavalleri, G. L., Godson, C., & Conlon, P. J. (2020). Cold Spring Harb Mol Case Stud, 6(5). (opens in a new window)https://doi.org/10.1101/mcs.a005462

Interleukin 1 Receptor 1 Knockout and Maternal High Fat Diet Exposure Induces Sex-Specific Effects on Adipose Tissue Adipogenic and Inflammatory Gene Expression in Adult Mouse Offspring. Bridge-Comer, P. E., Plows, J. F., Ramzan, F., Patel, R., Ganapathy, T. P., Stanley, J. L., Vickers, M. H., & Reynolds, C. M. (2020). Front Physiol, 11, 601. (opens in a new window)https://doi.org/10.3389/fphys.2020.00601

Improvements in diabetic albuminuria and podocyte differentiation following Roux-en-Y gastric bypass surgery. Canney, A. L., Cohen, R. V., Elliott, J. A., C, M. A., Martin, W. P., Docherty, N. G., & le Roux, C. W. (2020). Diab Vasc Dis Res, 17(1), 1479164119879039. (opens in a new window)https://doi.org/10.1177/1479164119879039

Regulating metabolic inflammation by nutritional modulation. Charles-Messance, H., Mitchelson, K. A. J., De Marco Castro, E., Sheedy, F. J., & Roche, H. M. (2020). J Allergy Clin Immunol, 146(4), 706-720. (opens in a new window)https://doi.org/10.1016/j.jaci.2020.08.013

Effect of Gastric Bypass vs Best Medical Treatment on Early-Stage Chronic Kidney Disease in Patients With Type 2 Diabetes and Obesity: A Randomized Clinical Trial. Cohen, R. V., Pereira, T. V., Aboud, C. M., Petry, T. B. Z., Lopes Correa, J. L., Schiavon, C. A., Pompílio, C. E., Pechy, F. N. Q., da Costa Silva, A. C. C., de Melo, F. L. G., Cunha da Silveira, L. P., de Paris Caravatto, P. P., Halpern, H., Monteiro, F. L. J., da Costa Martins, B., Kuga, R., Palumbo, T. M. S., Docherty, N. G., & le Roux, C. W. (2020). JAMA Surg, 155(8), e200420. (opens in a new window)https://doi.org/10.1001/jamasurg.2020.0420

Personalized Nutrition for Inflammatory Bowel Disease. Collins, C. B., & Roche, H. M. (2020). Crohns Colitis 360, 2(3), otaa042. (opens in a new window)https://doi.org/10.1093/crocol/otaa042

Bariatric surgery for the treatment of chronic kidney disease in obesity and type 2 diabetes mellitus. Docherty, N. G., & le Roux, C. W. (2020). Nat Rev Nephrol, 16(12), 709-720. (opens in a new window)https://doi.org/10.1038/s41581-020-0323-4

Promoting resolution in kidney disease: are we nearly there yet? Doyle, R., Godson, C., & Brennan, E. (2020). Curr Opin Nephrol Hypertens, 29(1), 119-127. (opens in a new window)https://doi.org/10.1097/mnh.0000000000000558

Metabolic dysfunction and diabetes mellitus during long-term follow-up of severe acute pancreatitis: A case-matched study. Duggan, S. N., O'Connor, D. B., Antanaitis, A., Campion, J. R., Lawal, O., Ahmed, M., Tisdall, A. R., Sherlock, M., Boran, G., le Roux, C., Gibney, J., & Conlon, K. C. (2020). Pancreatology, 20(5), 813-821. (opens in a new window)https://doi.org/10.1016/j.pan.2020.03.016

microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression. Fitzsimons, S., Oggero, S., Bruen, R., McCarthy, C., Strowitzki, M. J., Mahon, N. G., Ryan, N., Brennan, E. P., Barry, M., Perretti, M., & Belton, O. (2020). Front Immunol, 11, 576516. (opens in a new window)https://doi.org/10.3389/fimmu.2020.576516

Therapeutic Potential of Lipoxin A(4) in Chronic Inflammation: Focus on Cardiometabolic Disease. Fu, T., Mohan, M., Brennan, E. P., Woodman, O. L., Godson, C., Kantharidis, P., Ritchie, R. H., & Qin, C. X. (2020). ACS Pharmacol Transl Sci, 3(1), 43-55. (opens in a new window)https://doi.org/10.1021/acsptsci.9b00097

Balancing the Effect of Leukotrienes in Asthma. Godson, C. (2020). N Engl J Med, 382(15), 1472-1475. (opens in a new window)https://doi.org/10.1056/NEJMcibr2000118

Evaluation of Heart Rate Variability and Endothelial Function 3 Months After Bariatric Surgery. Gomide Braga, T., das Graças Coelho de Souza, M., Maranhão, P. A., Menezes, M., Dellatorre-Teixeira, L., Bouskela, E., Le Roux, C. W., & Kraemer-Aguiar, L. G. (2020). Obes Surg, 30(6), 2450-2453. (opens in a new window)https://doi.org/10.1007/s11695-020-04397-4

"I am terrified of something happening to me" The lived experience of people with obesity during the COVID-19 pandemic. Grannell, A., le Roux, C. W., & McGillicuddy, D. (2020). Clin Obes, 10(6), e12406. (opens in a new window)https://doi.org/10.1111/cob.12406

Simulating the Post-gastric Bypass Intestinal Microenvironment Uncovers a Barrier-Stabilizing Role for FXR. Hankir, M. K., Langseder, T., Bankoglu, E. E., Ghoreishi, Y., Dischinger, U., Kurlbaum, M., Kroiss, M., Otto, C., le Roux, C. W., Arora, T., Seyfried, F., & Schlegel, N. (2020). iScience, 23(12), 101777. (opens in a new window)https://doi.org/10.1016/j.isci.2020.101777

Substantial inter-individual variations in insulin secretion and sensitivity across the glucometabolic spectrum. Hansen, A. M. B., Wium, C., Lee, S., Tierney, A. C., McCarthy, D., Roche, H. M., Drevon, C. A., Birkeland, K. I., & Gulseth, H. L. (2020). Scand J Clin Lab Invest, 80(4), 282-290. (opens in a new window)https://doi.org/10.1080/00365513.2020.1730433

Optimisation of a metabotype approach to deliver targeted dietary advice. Hillesheim, E., Ryan, M. F., Gibney, E., Roche, H. M., & Brennan, L. (2020). Nutr Metab (Lond), 17, 82. (opens in a new window)https://doi.org/10.1186/s12986-020-00499-z

Gastric bypass in female rats lowers concentrated sugar solution intake and preference without affecting brief-access licking after long-term sugar exposure. Hyde, K. M., Blonde, G. D., Bueter, M., le Roux, C. W., & Spector, A. C. (2020). Am J Physiol Regul Integr Comp Physiol, 318(5), R870-r885. (opens in a new window)https://doi.org/10.1152/ajpregu.00240.2019

Double-blinded, randomized, and controlled study on the effects of canagliflozin after bariatric surgery: A pilot study. Kashyap, S. R., Kheniser, K., Aminian, A., Schauer, P., Le Roux, C., & Burguera, B. (2020). Obes Sci Pract, 6(3), 255-263. (opens in a new window)https://doi.org/10.1002/osp4.409

Obesity: A critical risk factor in the COVID-19 pandemic. Kwok, S., Adam, S., Ho, J. H., Iqbal, Z., Turkington, P., Razvi, S., Le Roux, C. W., Soran, H., & Syed, A. A. (2020). Clin Obes, 10(6), e12403. (opens in a new window)https://doi.org/10.1111/cob.12403

Biography: Carel le Roux. le Roux, C. W. (2020). Obes Surg, 30(6), 2074-2075. (opens in a new window)https://doi.org/10.1007/s11695-020-04618-w

A modelling approach to investigate the impact of consumption of three different beef compositions on human dietary fat intakes. Lenighan, Y. M., Nugent, A. P., Moloney, A. P., Monahan, F. J., Walton, J., Flynn, A., Roche, H. M., & McNulty, B. A. (2020). Public Health Nutr, 23(13), 2373-2383. (opens in a new window)https://doi.org/10.1017/s1368980019003471

Body composition after allogeneic haematopoietic cell transplantation/total body irradiation in children and young people: a restricted systematic review. Lorenc, A., Hamilton-Shield, J., Perry, R., & Stevens, M. (2020). J Cancer Surviv, 14(5), 624-642. (opens in a new window)https://doi.org/10.1007/s11764-020-00871-1

GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production. Mahootchi, E., Cannon Homaei, S., Kleppe, R., Winge, I., Hegvik, T. A., Megias-Perez, R., Totland, C., Mogavero, F., Baumann, A., Glennon, J. C., Miletic, H., Kursula, P., & Haavik, J. (2020). Sci Adv, 6(29), eabb3713. (opens in a new window)https://doi.org/10.1126/sciadv.abb3713

Obesity is common in chronic kidney disease and associates with greater antihypertensive usage and proteinuria: evidence from a cross-sectional study in a tertiary nephrology centre. Martin, W. P., Bauer, J., Coleman, J., Dellatorre-Teixeira, L., Reeve, J. L. V., Twomey, P. J., Docherty, N. G., O'Riordan, A., Watson, A. J., le Roux, C. W., & Holian, J. (2020). Clin Obes, 10(6), e12402. (opens in a new window)https://doi.org/10.1111/cob.12402

Can Metabolic Surgery Be Used to Improve Access to and Outcomes of Kidney Transplantation? Martin, W. P., & le Roux, C. W. (2020a). Obesity (Silver Spring), 28(12), 2259. (opens in a new window)https://doi.org/10.1002/oby.23052

Comment on: Impact of serum uric acid on renal function after bariatric surgery: a retrospective study. Martin, W. P., & le Roux, C. W. (2020b). Surg Obes Relat Dis, 16(2), 295-298. (opens in a new window)https://doi.org/10.1016/j.soard.2019.11.002

Parallel assessment of albuminuria and plasma sTNFR1 in people with type 2 diabetes and advanced chronic kidney disease provides accurate prognostication of the risks of renal decline and death. Martin, W. P., Tuohy, C., Doody, A., Jackson, S., Canavan, R. J., Slattery, D., Twomey, P. J., McKenna, M. J., le Roux, C. W., & Docherty, N. G. (2020). Sci Rep, 10(1), 14852. (opens in a new window)https://doi.org/10.1038/s41598-020-71684-6

Metabolic Surgery to Treat Obesity in Diabetic Kidney Disease, Chronic Kidney Disease, and End-Stage Kidney Disease; What Are the Unanswered Questions? Martin, W. P., White, J., López-Hernández, F. J., Docherty, N. G., & le Roux, C. W. (2020). Front Endocrinol (Lausanne), 11, 289. (opens in a new window)https://doi.org/10.3389/fendo.2020.00289

Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Maruvada, P., Lampe, J. W., Wishart, D. S., Barupal, D., Chester, D. N., Dodd, D., Djoumbou-Feunang, Y., Dorrestein, P. C., Dragsted, L. O., Draper, J., Duffy, L. C., Dwyer, J. T., Emenaker, N. J., Fiehn, O., Gerszten, R. E., F, B. H., Karp, R. W., Klurfeld, D. M., Laughlin, M. R., Little, A. R., Lynch, C. J., Moore, S. C., Nicastro, H. L., O'Brien, D. M., Ordovás, J. M., Osganian, S. K., Playdon, M., Prentice, R., Raftery, D., Reisdorph, N., Roche, H. M., Ross, S. A., Sang, S., Scalbert, A., Srinivas, P. R., & Zeisel, S. H. (2020). Adv Nutr, 11(2), 200-215. (opens in a new window)https://doi.org/10.1093/advances/nmz075

Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised controlled clinical trial. McCrimmon, R. J., Catarig, A. M., Frias, J. P., Lausvig, N. L., le Roux, C. W., Thielke, D., & Lingvay, I. (2020). Diabetologia, 63(3), 473-485. (opens in a new window)https://doi.org/10.1007/s00125-019-05065-8

Bariatric surgery for patients with type 2 diabetes mellitus requiring insulin: Clinical outcome and cost-effectiveness analyses. McGlone, E. R., Carey, I., Veličković, V., Chana, P., Mahawar, K., Batterham, R. L., Hopkins, J., Walton, P., Kinsman, R., Byrne, J., Somers, S., Kerrigan, D., Menon, V., Borg, C., Ahmed, A., Sgromo, B., Cheruvu, C., Bano, G., Leonard, C., Thom, H., le Roux, C. W., Reddy, M., Welbourn, R., Small, P., & Khan, O. A. (2020). PLoS Med, 17(12), e1003228. (opens in a new window)https://doi.org/10.1371/journal.pmed.1003228

Effects of acute aerobic, resistance and combined exercises on 24-h glucose variability and skeletal muscle signalling responses in type 1 diabetics. Minnock, D., Annibalini, G., Le Roux, C. W., Contarelli, S., Krause, M., Saltarelli, R., Valli, G., Stocchi, V., Barbieri, E., & De Vito, G. (2020). Eur J Appl Physiol, 120(12), 2677-2691. (opens in a new window)https://doi.org/10.1007/s00421-020-04491-6

Characterization of the renal cortical transcriptome following Roux-en-Y gastric bypass surgery in experimental diabetic kidney disease. Nair, M., Martin, W. P., Zhernovkov, V., Elliott, J. A., Fearon, N., Eckhardt, H., McCormack, J., Godson, C., Brennan, E. P., Fandriks, L., Docherty, N. G., & le Roux, C. W. (2020). BMJ Open Diabetes Res Care, 8(1). (opens in a new window)https://doi.org/10.1136/bmjdrc-2019-001113

The Effect of Metabolic Surgery on the Complications of Diabetes: What Are the Unanswered Questions? Neff, K. J., & Le Roux, C. W. (2020). Front Endocrinol (Lausanne), 11, 304. (opens in a new window)https://doi.org/10.3389/fendo.2020.00304

Predictors of weight loss after bariatric surgery-a cross-disciplinary approach combining physiological, social, and psychological measures. Nielsen, M. S., Christensen, B. J., Schmidt, J. B., Tækker, L., Holm, L., Lunn, S., Ritz, C., Wewer Albrechtsen, N. J., Holst, J. J., Schnurr, T. M., Hansen, T., le Roux, C. W., Lund, T. B., Floyd, A. K., & Sjödin, A. (2020). Int J Obes (Lond), 44(11), 2291-2302. (opens in a new window)https://doi.org/10.1038/s41366-020-0576-9

Oxyntomodulin and Glicentin May Predict the Effect of Bariatric Surgery on Food Preferences and Weight Loss. Nielsen, M. S., Ritz, C., Wewer Albrechtsen, N. J., Holst, J. J., le Roux, C. W., & Sjödin, A. (2020). J Clin Endocrinol Metab, 105(4). (opens in a new window)https://doi.org/10.1210/clinem/dgaa061

Conjugated Linoleic Acid and Alpha Linolenic Acid Improve Cholesterol Homeostasis in Obesity by Modulating Distinct Hepatic Protein Pathways. O'Reilly, M. E., Lenighan, Y. M., Dillon, E., Kajani, S., Curley, S., Bruen, R., Byrne, R., Heslin, A. M., Moloney, A. P., Roche, H. M., & McGillicuddy, F. C. (2020). Mol Nutr Food Res, 64(7), e1900599. (opens in a new window)https://doi.org/10.1002/mnfr.201900599

Effectiveness and cost of integrating a pragmatic pathway for prescribing liraglutide 3.0 mg in obesity services (STRIVE study): study protocol of an open-label, real-world, randomised, controlled trial. Papamargaritis, D., Al-Najim, W., Lim, J., Crane, J., Lean, M., le Roux, C., McGowan, B., O'Shea, D., Webb, D., Wilding, J., & Davies, M. J. (2020). BMJ Open, 10(2), e034137. (opens in a new window)https://doi.org/10.1136/bmjopen-2019-034137

Formyl peptide receptor type 2 agonists to kick-start resolution pharmacology. Perretti, M., & Godson, C. (2020). Br J Pharmacol, 177(20), 4595-4600. (opens in a new window)https://doi.org/10.1111/bph.15212

Dietary substitution of SFA with MUFA within high-fat diets attenuates hyperinsulinaemia and pancreatic islet dysfunction. Ralston, J. C., Nguyen-Tu, M. S., Lyons, C. L., Cooke, A. A., Murphy, A. M., Falvey, A., Finucane, O. M., McGillicuddy, F. C., Rutter, G. A., & Roche, H. M. (2020). Br J Nutr, 124(3), 247-255. (opens in a new window)https://doi.org/10.1017/s0007114520000859

Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery. Rubino, F., Cohen, R. V., Mingrone, G., le Roux, C. W., Mechanick, J. I., Arterburn, D. E., Vidal, J., Alberti, G., Amiel, S. A., Batterham, R. L., Bornstein, S., Chamseddine, G., Del Prato, S., Dixon, J. B., Eckel, R. H., Hopkins, D., McGowan, B. M., Pan, A., Patel, A., Pattou, F., Schauer, P. R., Zimmet, P. Z., & Cummings, D. E. (2020). Lancet Diabetes Endocrinol, 8(7), 640-648. (opens in a new window)https://doi.org/10.1016/s2213-8587(20)30157-1

Joint international consensus statement for ending stigma of obesity. Rubino, F., Puhl, R. M., Cummings, D. E., Eckel, R. H., Ryan, D. H., Mechanick, J. I., Nadglowski, J., Ramos Salas, X., Schauer, P. R., Twenefour, D., Apovian, C. M., Aronne, L. J., Batterham, R. L., Berthoud, H. R., Boza, C., Busetto, L., Dicker, D., De Groot, M., Eisenberg, D., Flint, S. W., Huang, T. T., Kaplan, L. M., Kirwan, J. P., Korner, J., Kyle, T. K., Laferrère, B., le Roux, C. W., McIver, L., Mingrone, G., Nece, P., Reid, T. J., Rogers, A. M., Rosenbaum, M., Seeley, R. J., Torres, A. J., & Dixon, J. B. (2020). Nat Med, 26(4), 485-497. (opens in a new window)https://doi.org/10.1038/s41591-020-0803-x

Impaired Tubular Reabsorption Is the Main Mechanism Explaining Increases in Urinary NGAL Excretion Following Acute Kidney Injury in Rats. Sancho-Martínez, S. M., Blanco-Gozalo, V., Quiros, Y., Prieto-García, L., Montero-Gómez, M. J., Docherty, N. G., Martínez-Salgado, C., Morales, A. I., López-Novoa, J. M., & López-Hernández, F. J. (2020). Toxicol Sci, 175(1), 75-86. (opens in a new window)https://doi.org/10.1093/toxsci/kfaa029

The Atlas of Inflammation Resolution (AIR). Serhan, C. N., Gupta, S. K., Perretti, M., Godson, C., Brennan, E., Li, Y., Soehnlein, O., Shimizu, T., Werz, O., Chiurchiù, V., Azzi, A., Dubourdeau, M., Gupta, S. S., Schopohl, P., Hoch, M., Gjorgevikj, D., Khan, F. M., Brauer, D., Tripathi, A., Cesnulevicius, K., Lescheid, D., Schultz, M., Särndahl, E., Repsilber, D., Kruse, R., Sala, A., Haeggström, J. Z., Levy, B. D., Filep, J. G., & Wolkenhauer, O. (2020). Mol Aspects Med, 74, 100894. (opens in a new window)https://doi.org/10.1016/j.mam.2020.100894

Early Post-operative Weight Change After Roux-en-Y Gastric Bypass Predicts Weight Loss at 12-Month Follow-up. Silveira, F. C., Docherty, N. G., Sallet, P. C., Moraes, M., Monclaro, T., Arruda, E. S. M., Pizani, C. E., Sallet, J. A., & le Roux, C. W. (2020). Obes Surg, 30(12), 5020-5025. (opens in a new window)https://doi.org/10.1007/s11695-020-04942-1

Comparison of Preoperative Remission Scores and Diabetes Duration Alone as Predictors of Durable Type 2 Diabetes Remission and Risk of Diabetes Complications After Bariatric Surgery: A Post Hoc Analysis of Participants From the Swedish Obese Subjects Study. Sjöholm, K., Carlsson, L. M. S., Taube, M., le Roux, C. W., Svensson, P. A., & Peltonen, M. (2020). Diabetes Care, 43(11), 2804-2811. (opens in a new window)https://doi.org/10.2337/dc20-0157

The metabolic benefits of different bariatric operations: what procedure to choose? Sudlow, A., le Roux, C. W., & Pournaras, D. J. (2020). Endocr Connect, 9(2), R28-r35. (opens in a new window)https://doi.org/10.1530/ec-19-0467

Why are adolescents with obesity and diabetes not having bariatric surgery earlier? Sudlow, A. C., & le Roux, C. W. (2021). Surg Obes Relat Dis, 17(1), 33-35. (opens in a new window)https://doi.org/10.1016/j.soard.2020.10.005

Long-term outcomes of bariatric surgery in patients with diabetes. Sudlow, A. C., Le Roux, C. W., & Pournaras, D. J. (2020). Expert Rev Endocrinol Metab, 15(3), 141-146. (opens in a new window)https://doi.org/10.1080/17446651.2020.1754191

Male Obesity Associated Gonadal Dysfunction and the Role of Bariatric Surgery. Sultan, S., Patel, A. G., El-Hassani, S., Whitelaw, B., Leca, B. M., Vincent, R. P., le Roux, C. W., Rubino, F., Aywlin, S. J. B., & Dimitriadis, G. K. (2020). Front Endocrinol (Lausanne), 11, 408. (opens in a new window)https://doi.org/10.3389/fendo.2020.00408

Where is Cingulate Cortex? A Cross-Species View. van Heukelum, S., Mars, R. B., Guthrie, M., Buitelaar, J. K., Beckmann, C. F., Tiesinga, P. H. E., Vogt, B. A., Glennon, J. C., & Havenith, M. N. (2020). Trends Neurosci, 43(5), 285-299. (opens in a new window)https://doi.org/10.1016/j.tins.2020.03.007

Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet. Wallenius, V., Elias, E., Elebring, E., Haisma, B., Casselbrant, A., Larraufie, P., Spak, E., Reimann, F., le Roux, C. W., Docherty, N. G., Gribble, F. M., & Fändriks, L. (2020). Gut, 69(8), 1423-1431. (opens in a new window)https://doi.org/10.1136/gutjnl-2019-319372

The Molecular Effects of a High Fat Diet on Endometrial Tumour Biology. Wilkinson, M., Sinclair, P., Dellatorre-Teixeira, L., Swan, P., Brennan, E., Moran, B., Wedekind, D., Downey, P., Sheahan, K., Conroy, E., Gallagher, W. M., Docherty, N., Roux, C. L., & Brennan, D. J. (2020). Life (Basel), 10(9). (opens in a new window)https://doi.org/10.3390/life10090188

Al-Ozairi E, AlAwadhi MM, Al Kandari J, Taghadom E, Abdullah M, Le Roux CW. Photo-Assisted Dietary Method Improves Estimates of Dietary Intake Among People with Sleeve Gastrectomy. Obes Surg. 2019 Feb 13. doi: 10.1007/s11695-019-03736-4. [Epub ahead of print].

Andrews D, Oliviero G, De Chiara L, Watson A, Rochford E, Wynne K, Kennedy C, Clerkin S, Doyle B, Godson C, Connell P, O'Brien C, Cagney G, Crean J. Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification. FASEB J. 2019 Feb 19:fj201800566RR. doi: 10.1096/fj.201800566RR. [Epub ahead of print].

Braga T, Kraemer-Aguiar LG, Docherty NG, Le Roux CW. Treating prediabetes: why and how should we do it? Minerva Med. 2019 Feb;110(1):52-61. doi: 10.23736/S0026-4806.18.05897-4. Epub 2018 Oct 29. Review.

Crifo B, Schaible B, Brown E, Halligan DN, Scholz CC, Fitzpatrick SF, Kirwan A, Roche HM, Criscuoli M, Naldini A, Giffney H, Crean D, Blanco A, Cavadas MA, Cummins EP, Fabian Z, Taylor CT. Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes. J Immunol. 2019 Mar 1;202(5):1521-1530. doi: 10.4049/jimmunol.1800912. Epub 2019 Jan 30.

de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C, Guiry PJ. Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms). Eur J Med Chem. 2019 Jan 15;162:80-108. doi: 0.1016/j.ejmech.2018.10.049. Epub 2018 Oct 23.

Elliott JA, Casey S, Murphy CF, Docherty NG, Ravi N, Beddy P, Reynolds JV, le Roux CW. Risk factors for loss of bone mineral density after curative esophagectomy. Arch Osteoporos. 2019 Jan 9;14(1):6. doi: 10.1007/s11657-018-0556-z.

Elliott JA, Docherty NG, Haag J, Eckhardt HG, Ravi N, Reynolds JV, le Roux CW. Attenuation of satiety gut hormones increases appetitive behavior after curative esophagectomy for esophageal cancer. Am J Clin Nutr. 2019 Feb 1;109(2):335-344. doi: 10.1093/ajcn/nqy324.

Lenighan YM, McNulty BA, Roche HM. Dietary fat composition: replacement of saturated fatty acids with PUFA as a public health strategy, with an emphasis on α-linolenic acid. Proc Nutr Soc. 2019 Jan 11:1-12. doi: 10.1017/S0029665118002793. [Epub ahead of print].

O'Reilly ME, Kajani S, Ralston JC, Lenighan YM, Roche HM, McGillicuddy FC. utritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages. Mol Nutr Food Res. 2019 Jan;63(2):e1800713. doi: 10.1002/mnfr.201800713. Epub 2018 Nov 20.

Roche HM. Dietary modulation of energy homoeostasis and metabolic-inflammation. Proc Nutr Soc. 2019 Feb 1:1-6. doi: 10.1017/S0029665118002872. [Epub ahead of print]

Suliman M, Buckley A, Al Tikriti A, Tan T, le Roux CW, Lessan N, Barakat M. Routine clinical use of Liraglutide 3 mg for the treatment of obesity: Outcomes in non-surgical and bariatric surgery patients. Diabetes Obes Metab. 2019 Feb 15. doi: 10.1111/dom.13672. [Epub ahead of print]

Al-Najim W, Docherty NG, le Roux CW. Food Intake and Eating Behavior After Bariatric Surgery. Physiol Rev. 2018 Jul 1;98(3):1113-1141. doi: 10.1152/physrev.00021.2017. Review.

Al-Najim W, le Roux CW. Pharmacotherapy in conjunction with lifestyle for the treatment of obesity complications, is it enough?Ann Transl Med. 2018 Dec;6(Suppl 2):S109. doi: 10.21037/atm.2018.11.60. No abstract available.

Al-Najim W, le Roux CW, Docherty NG. Integrated insights into the role of alpha-melanocyte stimulatory hormone in the control of food intake and glycaemia. Peptides. 2018 Feb;100:243-248. doi: 10.1016/j.peptides.2017.12.003. Review.·        

Abdeen GN, Miras AD, Alqhatani AR, le Roux CW. Sugar Detection Threshold After Laparoscopic Sleeve Gastrectomy in Adolescents. Obes Surg. 2018 May;28(5):1302-1307. doi: 10.1007/s11695-017-2999-5.

Balfe A, Lennon G, Lavelle A, Docherty NG, Coffey JC, Sheahan K, Winter DC, O'Connell PR. Isolation and gene expression profiling of intestinal epithelial cells: crypt isolation by calcium chelation from in vivo samples. Clin Exp Gastroenterol. 2018 Jan 12;11:29-37. doi: 10.2147/CEG.S145224. eCollection 2018.

Bass GA, Heneghan HM. Negative Press for Intraoperative Provocative Testing in Bariatric Surgery-Blown Out of Proportion? J Am Coll Surg. 2018 Oct;227(4):475. doi: 10.1016/j.jamcollsurg.2018.07.002. No abstract available.

Brennan EP, Mohan M, McClelland A, Tikellis C, Ziemann M, Kaspi A, Gray SP, Pickering R, Tan SM, Ali-Shah ST, Guiry PJ, El-Osta A, Jandeleit-Dahm K, Cooper ME, Godson C, Kantharidis P. Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease. J Am Soc Nephrol. 2018 May;29(5):1437-1448. doi: 10.1681/ASN.2017101112. Epub 2018 Feb 28.

Brennan EP, Mohan M, McClelland A, de Gaetano M, Tikellis C, Marai M, Crean D, Dai A, Beuscart O, Derouiche S, Gray SP, Pickering R, Tan SM, Godson-Treacy M, Sheehan S, Dowdall JF, Barry M, Belton O, Ali-Shah ST, Guiry PJ, Jandeleit-Dahm K, Cooper ME, Godson C, Kantharidis P. Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis. Diabetes. 2018 Dec;67(12):2657-2667. doi: 10.2337/db17-1317. Epub 2018 Sep 13.

Christensen BJ, Schmidt JB, Nielsen MS, Tækker L, Holm L, Lunn S, Bredie WLP, Ritz C, Holst JJ, Hansen T, Hilbert A, le Roux CW, Hulme OJ, Siebner H, Morville T, Naver L, Floyd AK, Sjödin A. Patient profiling for success after weight loss surgery (GO Bypass study): An interdisciplinary study protocol. Contemp Clin Trials Commun. 2018 Feb 17;10:121-130. doi: 10.1016/j.conctc.2018.02.002. eCollection 2018 Jun.

Chuah LL, Miras AD, Perry LM, Frankel AH, Towey DJ, Al-Mayahi Z, Svensson W, le Roux CW. Measurement of glomerular filtration rate in patients undergoing obesity surgery. BMC Nephrol. 2018 Dec 29;19(1):383. doi: 10.1186/s12882-018-1188-7.

Craig H, le Roux C, Keogh F, Finucane FM. How Ethical Is Our Current Delivery of Care to Patients with Severe and Complicated Obesity? Obes Surg. 2018 Jul;28(7):2078-2082. doi: 10.1007/s11695-018-3301-1. Review.

Curran AM, Scott-Boyer MP, Kaput J, Ryan MF, Drummond E, Gibney ER, Gibney MJ, Roche HM, Brennan L. A proteomic signature that reflects pancreatic beta-cell function. PLoS One. 2018 Aug 30;13(8):e0202727. doi: 10.1371/journal.pone.0202727. eCollection 2018.

de Gaetano M, McEvoy C, Andrews D, Cacace A, Hunter J, Brennan E, Godson C. Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications. Front Pharmacol. 2018 Dec 19;9:1488. doi: 10.3389/fphar.2018.01488. eCollection 2018. Review.

Doody A, Jackson S, Elliott JA, Canavan RJ, Godson C, Slattery D, Twomey PJ, McKenna MJ, le Roux CW, Docherty NG. Validating the association between plasma tumour necrosis factor receptor 1 levels and the presence of renal injury and functional decline in patients with Type 2 diabetes. J Diabetes Complications. 2018 Jan;32(1):95-99. doi: 10.1016/j.jdiacomp.2017.09.007. Epub 2017 Sep 18.

Doyle R, Sadlier DM, Godson C. Semin. Pro-resolving lipid mediators: Agents of anti-ageing? Immunol. 2018 Dec; 40:36-48. doi: 10.1016/j.smim.2018.09.002. Epub 2018 Oct 4. Review. PMID: 30293857.

Elliott JA, Casey S, Murphy CF, Docherty NG, Ravi N, Beddy P, Reynolds JV, le Roux CW. Risk factors for loss of bone mineral density after curative esophagectomy. Arch Osteoporos. 2019 Jan 9;14(1):6. doi: 10.1007/s11657-018-0556-z.

Fatima A, Connaughton RM, Weiser A, Murphy AM, O'Grada C, Ryan M, Brennan L, O'Gaora P, Roche HM. Weighted Gene Co-Expression Network Analysis Identifies Gender Specific Modules and Hub Genes Related to Metabolism and Inflammation in Response to an Acute Lipid Challenge. Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700388. Epub 2017 Dec 11.

Friedman AN, Wahed AS, Wang J, Courcoulas AP, Dakin G, Hinojosa MW, Kimmel PL, Mitchell JE, Pomp A, Pories WJ, Purnell JQ, le Roux C, Spaniolas K, Steffen KJ, Thirlby R, Wolfe B. Effect of Bariatric Surgery on CKD Risk. J Am Soc Nephrol. 2018 Apr;29(4):1289-1300. doi: 10.1681/ASN.2017060707. Epub 2018 Jan 15.

Glaysher MA, Mohanaruban A, Prechtl CG, Goldstone AP, Miras AD, Lord J, Chhina N, Falaschetti E, Johnson NA, Al-Najim W, Smith C, Li JV, Patel M, Ahmed AR, Moore M, Poulter N, Bloom S, Darzi A, Le Roux C, Byrne JP, Teare JP. A randomised controlled trial of a duodenal-jejunal bypass sleeve device (EndoBarrier) compared with standard medical therapy for the management of obese subjects with type 2 diabetes mellitus. BMJ Open. 2017 Nov 15;7(11):e018598. doi: 10.1136/bmjopen-2017-018598.

Heneghan HM, Kerrigan DD. Laparoscopic SADI-S as a salvage procedure for failed gastric bypass and sleeve gastrectomy: How I do it. Surg Obes Relat Dis. 2018 May;14(5):715-718. doi: 10.1016/j.soard.2018.01.043. Epub 2018 Feb 7. No abstract available.

Hughes MF, Lenighan YM, Godson C, Roche HM. Exploring Coronary Artery Disease GWAs Targets With Functional Links to Immunometabolism. Front Cardiovasc Med. 2018 Nov 6;5:148. doi: 10.3389/fcvm.2018.00148. eCollection 2018. Review.

Jain AK, le Roux CW, Puri P, Tavakkoli A, Gletsu-Miller N, Laferrère B, Kellermayer R, DiBaise JK, Martindale RG, Wolfe BM. Proceedings of the 2017 ASPEN Research Workshop-Gastric Bypass: Role of the Gut.

Kajani S, Curley S, McGillicuddy FC. Unravelling HDL-Looking beyond the Cholesterol Surface to the Quality Within. Int J Mol Sci. 2018 Jul 6;19(7). pii: E1971. doi: 10.3390/ijms19071971. Review. JPEN J Parenter Enteral Nutr. 2018 Feb;42(2):279-295. doi: 10.1002/jpen.1121. Review.

le Roux C, Aroda V, Hemmingsson J, Cancino AP, Christensen R, Pi-Sunyer X. Comparison of Efficacy and Safety of Liraglutide 3.0 mg in Individuals with BMI above and below 35 kg/m²: A Post-hoc Analysis.Obes Facts. 2017;10(6):531-544. doi: 10.1159/000478099. Epub 2017 Nov 17.

le Roux CW, Schauer PR. Prevention Is Better Than Cure: The Next Frontier for Bariatric Surgery? Ann Intern Med. 2018 Sep 4;169(5):343-344. doi: 10.7326/M18-2114. Epub 2018 Aug 7. No abstract available.

le Roux CW, Heneghan HM. Bariatric Surgery for Obesity. Med Clin North Am. 2018 Jan;102(1):165-182. doi: 10.1016/j.mcna.2017.08.011. Review.

Lyons CL, Roche HM. Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation. Int J Mol Sci. 2018 Oct 9;19(10). pii: E3092. doi: 10.3390/ijms19103092. Review.

Mangan A, Docherty NG, Le Roux CW, Al-Najim W. Current and emerging pharmacotherapy for prediabetes: are we moving forward? Expert Opin Pharmacother. 2018 Oct;19(15):1663-1673. doi: 10.1080/14656566.2018.1517155. Epub 2018 Sep 10. Review.

Mangan A, Le Roux CW, Miller NG, Docherty NG. Iron and Vitamin D/Calcium Deficiency after Gastric Bypass: Mechanisms Involved and Strategies to Improve Oral Supplement Disposition. Curr Drug Metab. 2018 Oct 26. doi: 10.2174/1389200219666181026160242. [Epub ahead of print].

Martin WP, Docherty NG, Le Roux CW. Impact of bariatric surgery on cardiovascular and renal complications of diabetes: a focus on clinical outcomes and putative mechanisms.Expert Rev Endocrinol Metab. 2018 Sep;13(5):251-262. doi: 10.1080/17446651.2018.1518130. Epub 2018 Sep 19.

McMorrow AM, Connaughton RM, Magalhães TR, McGillicuddy FC, Hughes MF, Cheishvili D, Morine MJ, Ennis S, Healy ML, Roche EF, Tremblay RE, Szyf M, Lithander FE, Roche HM. Personalized Cardio-Metabolic Responses to an Anti-Inflammatory Nutrition Intervention in Obese Adolescents: A Randomized Controlled Crossover Trial. Mol Nutr Food Res. 2018 May;62(10):e1701008. doi: 10.1002/mnfr.201701008.

Mingrone G, Bornstein S, Le Roux CW. Optimisation of follow-up after metabolic surgery. Lancet Diabetes Endocrinol. 2018 Jun;6(6):487-499. doi: 10.1016/S2213-8587(17)30434-5. Epub 2018 Jan 29. Review.

Miras AD, Kamocka A, Patel D, Dexter S, Finlay I, Hopkins JC, Khan O, Reddy M, Sedman P, Small P, Somers S, Cro S, Walton P, le Roux CW, Welbourn R. Obesity surgery makes patients healthier and more functional: real world results from the United Kingdom National Bariatric Surgery Registry. Surg Obes Relat Dis. 2018 Jul;14(7):1033-1040. doi: 10.1016/j.soard.2018.02.012. Epub 2018 Feb 15.

Miras AD, le Roux CW. Surgery: The new gold-standard - medical gastric bypass. Nat Rev Endocrinol. 2018 May;14(5):257-258. doi: 10.1038/nrendo.2018.28. Epub 2018 Mar 16. No abstract available.

Murphy CF, Docherty NG, le Roux CW. Liraglutide: another reason to target prediabetes?

Murphy CF, le Roux CW. Can we exonerate GLP-1 receptor agonists from blame for adverse pancreatic events? Ann Transl Med. 2018 May;6(10):186. doi: 10.21037/atm.2018.03.06. No abstract available.

Ooi GJ, Earnest A, Doyle L, Laurie C, Wentworth JM, Sikaris K, le Roux CW, Burton PR, O'Brien PE, Brown WA. Detailed Description of Change in Serum Cholesterol Profile with Incremental Weight Loss After Restrictive Bariatric Surgery. Obes Surg. 2018 May;28(5):1351-1362. doi: 10.1007/s11695-017-3015-9.

Patel N, Mohanaruban A, Ashrafian H, Le Roux C, Byrne J, Mason J, Hopkins J, Kelly J, Teare J. EndoBarrier®: a Safe and Effective Novel Treatment for Obesity and Type 2 Diabetes? Obes Surg. 2018 Jul;28(7):1980-1989. doi: 10.1007/s11695-018-3123-1.

Roncero-Ramos I, Rangel-Zuñiga OA, Lopez-Moreno J, Alcala-Diaz JF, Perez-Martinez P, Jimenez-Lucena R, Castaño JP, Roche HM, Delgado-Lista J, Ordovas JM, Camargo A, Lopez-Miranda J. Mediterranean Diet, Glucose Homeostasis, and Inflammasome Genetic Variants: The CORDIOPREV Study. Mol Nutr Food Res. 2018 May;62(9):e1700960. doi: 10.1002/mnfr.201700960. Epub 2018 Apr 20.

Sergi D, Campbell FM, Grant C, Morris AC, Bachmair EM, Koch C, McLean FH, Muller A, Hoggard N, de Roos B, Porteiro B, Boekschoten MV, McGillicuddy FC, Kahn D, Nicol P, Benzler J, Mayer CD, Drew JE, Roche HM, Muller M, Nogueiras R, Dieguez C, Tups A, Williams LM. SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice. Genes Nutr. 2018 Nov 29;13:28. doi: 10.1186/s12263-018-0619-1. eCollection 2018.

Shulman A, Peltonen M, Andersson-Assarsson JC, Sjöholm K, le Roux CW, Svensson PA. Reply: Bariatric surgery and chronic kidney disease: much hope, but proof is still awaited. Int J Obes (Lond). 2018 Aug;42(8):1534. doi: 10.1038/s41366-018-0159-1. Epub 2018 Jul 17. No abstract available.

Sinclair P, Brennan DJ, le Roux CW. Gut adaptation after metabolic surgery and its influences on the brain, liver and cancer. Nat Rev Gastroenterol Hepatol. 2018 Oct;15(10):606-624. doi: 10.1038/s41575-018-0057-y. Review.

Sinclair P, Docherty N, le Roux CW. Metabolic Effects of Bariatric Surgery. Clin Chem. 2018 Jan;64(1):72-81. doi: 10.1373/clinchem.2017.272336. Epub 2017 Nov 21. Review.

Sladek S, Kearney C, Crean D, Brama PAJ, Tajber L, Fawcett K, Labberte MC, Leggett B, Brayden DJ. Intra-articular delivery of a nanocomplex comprising salmon calcitonin, hyaluronic acid, and chitosan using an equine model of joint inflammation. Drug Deliv Transl Res. 2018 Oct;8(5):1421-1435. doi: 10.1007/s13346-018-0557-x.

Søndergaard Nielsen M, Rasmussen S, Just Christensen B, Ritz C, le Roux CW, Berg Schmidt J, Sjödin A. Bariatric Surgery Does Not Affect Food Preferences, but Individual Changes in Food Preferences May Predict Weight Loss. Obesity (Silver Spring). 2018 Dec;26(12):1879-1887. doi: 10.1002/oby.22272. Epub 2018 Nov 13.

Spector AC, Kapoor N, Price RK, Pepino MY, E Livingstone MB, le Roux CW. Proceedings from the 2018 Association for Chemoreception Annual Meeting Symposium: Bariatric Surgery and Its Effects on Taste and Food Selection. Chem Senses. 2018 Dec 4. doi: 10.1093/chemse/bjy076. [Epub ahead of print].

Tang T, Abbott S, le Roux CW, Wilson V, Singhal R, Bellary S, Tahrani AA. Preoperative weight loss with glucagon-like peptide-1 receptor agonist treatment predicts greater weight loss achieved by the combination of medical weight management and bariatric surgery in patients with type 2 diabetes: A longitudinal analysis. Diabetes Obes Metab. 2018 Mar;20(3):745-748. doi: 10.1111/dom.13131. Epub 2017 Nov 22.

Wallenius V, Dirinck E, Fändriks L, Maleckas A, le Roux CW, Thorell A. Glycemic Control after Sleeve Gastrectomy and Roux-En-Y Gastric Bypass in Obese Subjects with Type 2 Diabetes Mellitus. Obes Surg. 2018 Jun;28(6):1461-1472. doi: 10.1007/s11695-017-3061-3.

van Zuydam NR, Ahlqvist E, Sandholm N, Deshmukh H, …. Brennan EP, Sadlier DM, Martin F, Godson C,….McCarthy MI. A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. Diabetes. 2018 Jul;67(7):1414-1427. doi: 10.2337/db17-0914. Epub 2018 Apr 27.·         Werling M, Fändriks L, Olbers T, Mala T, Kristinsson J, Stenlöf K, Wallenius V, Docherty NG, le Roux CW. Biliopancreatic Diversion is associated with greater increases in energy expenditure than Roux-en-Y Gastric Bypass. PLoS One. 2018 Apr 4;13(4):e0194538. doi: 10.1371/journal.pone.0194538. eCollection 2018.

Arora T, Seyfried F, Docherty N.G, le Roux C.W, Perkins R, Bäckhed F Diabetes-associated microbiota in fa/fa rats is modified by Roux-en-Y gastric bypass International Society of Microbial Ecology Journal (ISME) 2017. 11(9):2035-2046 201.

Borgeson E, Wallenius, Syed, GH Darshi, M Rodriguez JL Bioresrud C Ragnmark Ek M Bjorklund P, Quiding-Jabrink, M Fandriks L Godson C* Sharma, K High-fat diet-induced pathophysiology is reduced by AICAR in an adiponectin-independent manner Diabetalogia 2017 Apr;60(4):729-739.

Boulenouar S, Michelet X, Duquette D, Alvarez D, Hogan AE, Dold C, O'Connor D, Stutte S, Tavakkoli A, Winters D, Exley MA, O'Shea D, Brenner MB, von Andrian U, Lynch L. Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity Immunity. 2017 Feb 21;46(2):273-286. PMID: 28228283.

Brennan E, Wang B, McClelland A, Mohan M, Marai M, Beuscart O, Derouiche S, Gray S, Pickering R, Tikellis C, de Gaetano M, Barry M, Belton O, Ali-Shah ST, Guiry P, Jandeleit-Dahm KAM, Cooper ME, Godson C, Kantharidis P. Protective Effect of let-7 miRNA Family in Regulating Inflammation in Diabetes-Associated Atherosclerosis. Diabetes. 2017 Aug;66(8):2266-2277.

Brennan EP, Cacace A, Godson C. Specialized pro-resolving mediators in renal fibrosis. Mol Aspects Med. 2017 May 11.

Bruen R, Curley S, Kajani S, Crean D, O'Reilly ME, Lucitt MB, Godson CG, McGillicuddy FC, Belton O. Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis. Cardiovasc Diabetol. 2017 Nov 6;16(1):143-156.

Bruen R, Fitzsimons S, Belton O. Atheroprotective effects of conjugated linoleic acid. Br J Clin Pharmacol. 2017 Jan;83(1):46-53.

Cohen R, Le Roux CW, Junqueira S, Ribeiro RA, Luque A. Roux-En-Y Gastric Bypass in Type 2 Diabetes Patients with Mild Obesity: a Systematic Review and Meta-analysis. Obes Surg. 2017 Aug 7.

Cohen RV, Luque A, Junqueira S, Ribeiro RA, Le Roux CW. What is the impact on the healthcare system if access to bariatric surgery is delayed? Surg Obes Relat Dis. 2017 Sep;13(9):1619-1627. doi: 10.1016/j.soard.2017.03.025. Epub 2017 Mar 31. PMID: 28499887.

Cummins EP, Crean D. 'Hypoxia and Inflammatory Bowel Disease.' Microbes and infection. 2017; 19(3):210-21.

DeChiara L., Andrews D., Watson A., Oliviero G.,  Cagney G. and Crean J. miR302 regulates SNAI1 expression to control mesangial cell plasticity Scientific Reports, 2017, in press.

Docherty N.G, Fändriks L, le Roux C.W, Hallesrund P, Werling M. Urinary Sodium Excretion after Gastric Bypass Surgery Surgery for Obesity and Related Diseases (SOARD)  13(9):1506-1514 2017.

Doody A, Jackson, S, Elliott JA, Canavan R, Godson C, Slattery D, Twomey P, McKenna M, le Roux CW, Docherty NG 1Validating the Association between Plasma Tumour Necrosis Factor Receptor 1 Levels and the Presence of Renal Injury and Functional Decline in Patients with Type 2 Diabetes Journal of Diabetes & its Complications 2017 [Epub ahead of print].

Elliott JA, Docherty N.G, Eckhardt HG, Doyle SL, Guinan EM, Ravi N, Reynolds JV, Roux CW. Weight Loss, Satiety, and the Postprandial Gut Hormone Response After Esophagectomy: A Prospective Study. Annals of  Surgery  266(1):82-90 2017.

Higgins DF, Ewart LM, Masterson E, Tennant S, Grebnev G, Prunotto M, Pomposiello S, Conde-Knape K, Martin FM, Godson C. BMP7-induced-Pten inhibits Akt and prevents renal fibrosis. Biochim Biophys Acta. 2017 Sep 18;1863(12):3095-3104.

Hyde KM, Blonde GD, le Roux CW, Spector AC. Liraglutide suppression of caloric intake competes with the intake-promoting effects of a palatable cafeteria diet, but does not impact food or macronutrient selection. Physiol Behav. 2017 Aug 1;177:4-12.

Laurenius A, Werling M, le Roux CW, Fändriks L, Olbers T. Dumping symptoms is triggered by fat as well as carbohydrates in patients operated with Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2017 Jul;13(7):1159-1164.

le Roux CW, Astrup A, Fujioka K, Greenway F, Lau DC, Van Gaal L, Ortiz RV, Wilding JP, Skjøth TV, Manning LS, Pi-Sunyer X; 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. SCALE Obesity.; Prediabetes NN8022-1839 Study Group. Lancet. 2017 Feb 22. pii: S0140-6736(17)30069-7.

MacLellan GA, Dunlevy C, O'Malley E, Blake C, Breen C, Gaynor K, Wallace N, Yoder R, Casey D, Mehegan J, O'Shea D, Fullen BM. Musculoskeletal pain profile of obese individuals attending a multidisciplinary weight management service Pain. 2017 Apr 5.

Marcone S, Belton O, Fitzgerald DJ. Milk-derived bioactive peptides and their health promoting effects: a potential role in atherosclerosis. Br J Clin Pharmacol. 2017 Jan;83(1):152-162.

Mazzei L, Cuello-Carrión FD, Docherty NG, Manucha W. Heat shock protein 70/nitric oxide effect on stretched tubular epithelial cells linked to WT-1 cytoprotection during neonatal obstructive nephropathy. Int Urol Nephrol. 2017 [Epub ahead of print].

McEvoy C, de Gaetano M, Giffney HE, Bahar B, Cummins EP, Brennan EP, Barry M, Belton O, Godson CG, Murphy EP, Crean D. NR4A Receptors Differentially Regulate NF-κB Signaling in Myeloid Cells. Front Immunol. 2017 Jan 23;8:7.

Miras AD, Herring R, Vusirikala A, Shojaee-Moradi F, Jackson NC, Chandaria S, Jackson SN, Goldstone AP, Hakim N, Patel AG, Umpleby AM, Le Roux CW. Measurement of hepatic insulin sensitivity early after the bypass of the proximal small bowel in humans. Obes Sci Pract. 2017 Mar;3(1):95-98.

Miras AD, le Roux CW. Metabolic Surgery in a Pill. Cell Metab. 2017 May 2;25(5):985-987.

Neff K.J,  Elliott J.A, Jackson S.N,   Corteville C,  Abegg K, Godson C, , Boza C,  Lutz T.A,  Docherty N.G,  le Roux C.W.  Effect of Roux-en-Y Gastric Bypass and Diet induced Weight Loss on Diabetic Kidney Disease in the Zucker Diabetic Fatty Rat Surgery for Obesity and Related Diseases (SOARD) 13(1):21-27 2017.

Nielsen MS, Christensen BJ, Ritz C, Rasmussen S, Hansen TT, Bredie WLP, le Roux CW, Sjödin A, Schmidt JB. Roux-En-Y Gastric Bypass and Sleeve Gastrectomy Does Not Affect Food Preferences When Assessed by an Ad libitum Buffet Meal. Obes Surg. 2017 Apr 14.

O'Neill KN, Finucane FM, le Roux CW, Fitzgerald AP, Kearney PM. Unmet need for bariatric surgery. Surg Obes Relat Dis. 2017 Jun;13(6):1052-1056. doi: 10.1016/j.soard.2016.12.015. Epub 2016 Dec 23. PMID: 28256395.

Ooi GJ, Doyle L, Tie T, Wentworth JM, Laurie C, Earnest A, Cowley MA, Sikaris K, le Roux CW, Burton PR, O'Brien PE, Brown WA. Weight loss after laparoscopic adjustable gastric band and resolution of the metabolic syndrome and its components. Int J Obes (Lond). 2017 Jun;41(6):902-908.

Risstad H, Kristinsson JA, Fagerland MW, le Roux CW, Birkeland KI, Gulseth HL, Thorsby PM, Vincent RP, Engström M, Olbers T, Mala T. Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial. Surg Obes Relat Dis. 2017 Sep;13(9):1544-1553.

Taha O, Hussein A, Abdelaal M, al-Najim W, le Roux CW, Docherty NG Impact of abdominal subcutaneous fat reduction on glycemic control in obese patients with type 2 diabetes mellitus Bariatric Surgical Practice and Patient Care 2017 in press.

Tang T, Abbott S, le Roux CW, Wilson V, Singhal R, Bellary S, Tahrani A. Preoperative Weight Loss With GLP-1 Receptor Agonist Treatment Predicts Greater Weight Loss Achieved by the Combination of Medical Weight Management And Bariatric Surgery In Patients With Type 2 Diabetes: A Longitudinal Analysis. Diabetes Obes Metab. 2017 Oct 20. doi: 10.1111/dom.13131. Epub ahead of print] PMID: 29053203.

Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, McKay GJ, Maxwell AP, Taylor CT, Cummins EP, Godson C, Higgins DF, Murphy P, Crean J. Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F35-45.

Cavadas MAS, Mesnieres M, Crifo B, Cabrero Manresa M, Selfridge,AC  Fabian Z, Scholz CC, Nolan KA, Rocha LA, Tambuwala MM, Brown S, Wdowicz A, Corbett D, Murphy KJ, Godson C, Cummins EP, TaylorCT, Cheong A REST is a hypoxia-inducible repressor of transcription  Sci Reports 2016.

Coluzzi I, Raparelli L, Guarnacci L, Paone E, Del Genio G, le Roux CW, Silecchia G. Food Intake and Changes in Eating Behavior After Laparoscopic Sleeve Gastrectomy. Obes Surg. 2016 Jan 7. [Epub ahead of print] PMID: 26744284.

Connaughton RM, McMorrow AM, McGillicuddy FC, Lithander FE, Roche HM. Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood. Proc Nutr Soc 75(02):115-124, 2016.

Cummins EP, Keogh CE, Crean D, Taylor CT. 'The Role of HIF in Immunity and Inflammation.' Mol Aspects Med. 2016; 47-48:24-34.

De Chiara L, Crean J. Emerging Transcriptional Mechanisms in the Regulation of Epithelial to Mesenchymal Transition and Cellular Plasticity in the Kidney. J Clin Med. 2016 Jan 12; 5(1). pii: E6. doi: 10.3390/jcm5010006.

de Gaetano M, Crean D, Barry M, Belton O. M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human Atherosclerosis. Front Immunol. 2016 Jul 19;7:275. doi: 10.3389/fimmu.2016.00275.

Dutia R, Embrey M, O'Brien S, Haeusler RA, Agénor KK, Homel P, McGinty J, Vincent RP, Alaghband-Zadeh J, Staels B, le Roux CW, Yu J, Laferrère B. Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes. Int J Obes (Lond). 2016 Mar;40(3):554.

Elliott JA, le Roux CW. Type 2 diabetes with BMI<30 kg/m2: Can we predict success of metabolic surgery? Surg Obes Relat Dis. 2016 Mar 16. pii: S1550-7289(16)00102-7. doi: 10.1016/j.soard.2016.03.012. PMID: 27130137.

Gaul D, Mat A, O'Shea D, Issartel J. Impaired Visual Motor Coordination in Obese Adults., J Obes. 2016;2016:6178575. Epub 2016 Nov 22. PMID: 27994885.

Healy NP, Kirwan AM, McArdle MA, Holohan K, Nongonierma AB, Keane D, Kelly S, Celkova L, Lyons CL, McGillicuddy FC, Finucane OM, Murray BA, Kelly PM, Brennan L, Fitzgerald RJ, Roche HM. A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome‐mediated inflammation and improving insulin signaling.  Mol Nutr Food Res 2016.

Hunt KF, Dunn JT, le Roux CW, Reed LJ, Marsden PK, Patel AG, Amiel SA. Differences in Regional Brain Responses to Food Ingestion After Roux-en-Y Gastric Bypass and the Role of Gut Peptides: A Neuroimaging Study. Diabetes Care. 2016 Oct;39(10):1787-95. doi: 10.2337/dc15-2721. PMID: 27660120.

Jung J, Ha TK, Lee J, Lho Y, Nam M, Lee D, le Roux CW, Ryu DH, Ha E, Hwang GS. Changes in one-carbon metabolism after duodenal-jejunal bypass surgery. Am J Physiol Endocrinol Metab. 2016 Jan 19:ajpendo.00260.2015.

le Roux C.W, Engstrom M,, Bjornfot N,, Fandriks L, Docherty N.G Equivalent Increases in Circulating GLP-1 Following Jejunal Delivery of Intact and Hydrolysed Casein: Relevance to Satiety Induction Following Bariatric Surgery. Obesity surgery 26(8):1851-8 2016.

Lynch L, Hogan AE, Duquette D, Lester C, Banks A, LeClair K, Cohen DE, Ghosh A, Lu B, Corrigan M, Stevanovic D, Maratos-Flier E, Drucker DJ, O'Shea D, Brenner M. iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy. Cell Metab. 2016 Sep 13;24(3):510-9.PMID: 27593966.

Lyons CL, Kennedy EB, Roche HM, 2016. Metabolic Inflammation-Differential Modulation by Dietary Constituents. Nutrients, 8(5):247, 2016.

Maghsoodi N, Alaghband-Zadeh J, Cross G, Werling M, Fandriks L, Docherty NG, Olbers T, Dew T, Sherwood R, Vincent R.P, Le Roux C.W. Elevated Fasting & Post-prandial C-Terminal Telopeptide (CTX) after Roux-en-Y gastric bypass (RYGB). Ann Clin Biochem. 54(4):495-500 2016.

Mathes CM, Letourneau C, Blonde GD, le Roux CW, Spector AC. Roux-en-Y Gastric Bypass in Rats Progressively Decreases the Proportion of Fat Calories Selected from a Palatable Cafeteria Diet. Am J Physiol Regul Integr Comp Physiol. 2016 Feb 10:ajpregu.00444.2015.

McDarby F, O'Hora D, O'Shea D, Byrne M. Pediatr Obes. Taking the sweetness out of the 'Share a Coke' marketing campaign: the influence of personalized labelling on elementary school children's bottled drink choices 2016 Nov 24. doi: 10.1111/ijpo.12193. PMID: 27884050.

McKay, G., Kavanagh, D., Crean, J., Maxwell, A.P. Bioinformatic evaluation of transcriptional regulation of WNT pathway genes with reference to diabetic nephropathy. Journal of Diabetes Research, 2016:7684038. doi: 10.1155/2016/7684038.

McKenna I, Hughes S, Barnes-Holmes D, De Schryver M, Yoder R, O'Shea D. Obesity, food restriction, and implicit attitudes to healthy and unhealthy foods: Lessons learned from the implicit relational assessment procedure. Appetite. 2016 May 1;100:41-54. doi: 10.1016/j.appet.2016.02.013. Epub 2016 Feb 11. PMID: 2687721

Mossberg KE, Pournaras DJ, Welbourn R, le Roux CW, Brogren H. Differential response of plasma plasminogen activator inhibitor 1 after weight loss surgery in patients with or without type 2 diabetes. Surg Obes Relat Dis. 2016 Mar 14. PMID: 27387691.

Neff KJ, Baud G, Raverdy V, Caiazzo R, Verkindt H, Noel C, le Roux CW, Pattou F. Renal Function and Remission of Hypertension After Bariatric Surgery: a 5-Year Prospective Cohort Study. Obes Surg. 2016 Sep 14. PMID: 27628054.

Neff KJ, le Roux CW. Bariatric surgery: traversing the CROSSROADS into mainstream diabetes care. Diabetologia. 2016 May;59(5):942-4. doi: 10.1007/s00125-016-3928-1. Epub 2016 Mar 16. No abstract available. PMID: 26983923.

O’Reilly M, Dillon E, Guo W, Finucane O, McMorrow A, Murphy A, Lyons C, Jones D, Ryan M, Gibney M, Gibney E, Brennan L, de la Llera Moya M, Reilly M.P, Roche H M, McGillicuddy FC. High-Density Lipoprotein Proteomic Composition, and not Efflux Capacity, Reflects Differential Modulation of Reverse Cholesterol Transport by Saturated and Monounsaturated Fat Diets.  Circulation 133, 1838-1850, 2016. DOI: 10.1161/CIRCULATIONAHA.115.020278. 

O’Sullivan S, Jun Wang J , Docherty N.G, , Noreen Boyle2 Kana-Lis S, Gilmer J, Medina C. Inhibition of Matrix Metalloproteinase-9 by a Barbituate-Nitrate Hybrid Ameliorates Dextran Sulphate Sodium-Induced Colitis-Effect on Inflammation Related Genes British Journal of Pharmacology 174(7):512-524 2016.

Oliverio G., O’Brien GL, Watson A, Streubel G, Jerman E, Andrews D, Doyle B, Munawar N, Bracken A, Crean J, Cagney G. Dynamic Protein interactions of the Polycomb Repressive Complex 2 during differentiation of pluripotent cells. Molecular and Cellular Proteomics, 2016. doi: 10.1074/mcp.M116.062240.

Pournaras DJ, Hardwick RH, le Roux CW. Gastrointestinal surgery for obesity and cancer: 2 sides of the same coin. Surg Obes Relat Dis. 2016 Dec 23. pii: S1550-7289(16)30878-4. doi: 10.1016/j.soard.2016.12.014. [Epub ahead of print] PMID: 28161354.

Pournaras DJ, Nygren J, Hagström-Toft E, Arner P, le Roux CW, Thorell A. Improved glucose metabolism after gastric bypass: evolution of the paradigm. Surg Obes Relat Dis. 2016 Mar 23. PMID: 27387696

Qvigstad E, Gulseth HL, Risstad H, le Roux CW, Berg TJ, Mala T, Kristinsson JA. A novel technique of Roux-en-Y gastric bypass reversal for postprandial hyperinsulinemic hypoglycaemia: A case report. Int J Surg Case Rep. 2016 Feb 27;21:91-94. doi: 10.1016/j.ijscr.2016.02.033. PMID: 26957187.

van Avesaat M, Troost FJ, Westerterp-Plantenga MS, Helyes Z, le Roux CW, Dekker J, Masclee AA, Keszthelyi D. Capsaicin-induced satiety is associated with gastrointestinal distress but not with the release of satiety hormones. Am J Clin Nutr. 2016 Feb;103(2):305-13.

Wang B, Yao K, Huuskes BM, Shen H-H, Zhuang J, Godson C, Brennan EP, Wilkinson-Berka JL, Wise AF, Ricardo SD. Mesenchymal stem cells deliver exogenous microRNA let7c via exosomes to attenuate renal fibrosis Mol. Ther.  Aug;24(7):1290-30 2016.

Welbourn R, Dixon J, Barth JH, Finer N, Hughes CA, le Roux CW, Wass J; Guidance Development Group. NICE-Accredited Commissioning Guidance for Weight Assessment and Management Clinics: a Model for a Specialist Multidisciplinary Team Approach for People with Severe Obesity. Obes Surg. 2016 Jan 6. [Epub ahead of print] PMID: 26738895.

Welbourn R, le Roux CW, Owen-Smith A, Wordsworth S, Blazeby JM. Why the NHS should do more bariatric surgery; how much should we do? BMJ. 2016 May 11;353:i1472. doi: 10.1136/bmj.i1472. PMID: 27169605.

Wilding JP, Overgaard RV, Jacobsen LV, Jensen CB, le Roux CW. Exposure-response analyses of liraglutide 3.0 mg for weight management. Diabetes Obes Metab. 2016 Feb 2. doi: 10.1111/dom.12639. [Epub ahead of print] PMID: 26833744.

Zanchi D, Meyer-Gerspach AC, Suenderhauf C, Janach K, le Roux CW, Haller S, Drewe J, Beglinger C, Wölnerhanssen BK, Borgwardt S. Differential effects of L-tryptophan and L-leucine administration on brain resting state functional networks and plasma hormone levels. Sci Rep. 2016 Oct 20;6:35727.

Chuah LL, Miras AD, Papamargaritis D, Jackson SN, Olbers T, le Roux CW. Impact of perioperative management of glycemia in severely obese diabetic patients undergoing gastric bypass surgery. Surg Obes Relat Dis. 2015 May-Jun;11(3):578-84. doi: 10.1016/j.soard.2014.11.004. Epub 2014 Nov 13. PMID: 25863535.

Abegg K, Corteville C, Docherty N.G, Boza C, Lutz T.A, Muñoz R, le Roux C.W. Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol 15;308(4):R321-329. 2015.

Alsters SI, Goldstone AP, Buxton JL, Zekavati A, Sosinsky A, Yiorkas AM, Holder S, Klaber RE, Bridges N, van Haelst MM, le Roux CW, Walley AJ, Walters RG, Mueller M, Blakemore AI. Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism. PLoS One. 2015 Jun 29;10(6):e0131417.

Arora T, Velagapudi V, Pournaras DJ, Welbourn R, le Roux CW, Orešič M, Bäckhed F. Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission. PLoS One. 2015 May 6;10 (5):e0126401. doi: 10.1371/journal.pone.0126401. eCollection 2015. PMID: 25946120.

Belgaumkar AP, Vincent RP, Carswell KA, Hughes RD, Alaghband-Zadeh J, Mitry RR, le Roux CW, Patel AG. Changes in Bile Acid Profile After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Metabolic Profile and Fatty Liver Disease. Obes Surg. 2015 Sep 4. [Epub ahead of print] PMID: 26337697.

Borgeson E, Johnston,A  Lee, YS, Till,A Syed, GH Ali Shah, T, Guiry PJ, Dalli, J Colas,R Serhan, CN, Sharma, K and Godson C.  Lipoxin A4 attenuates obesity-induced adipose inflammation and associated liver and kidney disease. Cell Metab. 2015 Jul 7;22(1):125-3.

Boxwell AJ, Chen Z, Mathes CM, Spector AC, le Roux CW, Travers SP, Travers JB. Effects of high-fat diet and gastric bypass on neurons in the caudal solitary nucleus. Physiol Behav. 2015 Dec 1;152(Pt B):329-39.

Breen C, Ryan M, Gibney MJ, O'Shea D. Diabetes-related nutrition knowledge and dietary intake among adults with type 2 diabetes. Br J Nutr. 2015 Aug 14;114(3):439-47.

Carolan E, Tobin LM, Mangan BA, Corrigan M, Gaoatswe G, Byrne G, Geoghegan J, Cody D, O'Connell J, Winter DC, Doherty DG, Lynch L, O'Shea D, Hogan AE. Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity  J Immunol. 2015 Jun 15;194(12):5775-80.

Crean D, Cummins EP, Bahar B, Mohan H, McMorrow JP, Murphy EP. 'Adenosine Modulates NR4A Orphan Nuclear Receptors to Attenuate Hyperinflammatory Responses in Monocytic Cells.' J Immunol. 2015; 195(4):1436-48.

de Gaetano M, Alghamdi K, Marcone S, Belton O. Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation. J Inflamm (Lond). 2015 Feb 19;12:15. doi: 10.1186/s12950-015-0060-9. eCollection 2015.

de Jonge C, Rensen SS, Verdam FJ, Vincent RP, Bloom SR, Buurman WA, le Roux CW, Bouvy ND, Greve JW. Impact of Duodenal-Jejunal Exclusion on Satiety Hormones. Obes Surg. 2015 Oct 7. [Epub ahead of print] PMID: 26446491.

Del Genio G, Gagner M, Limongelli P, Tolone S, Pournaras D, le Roux CW, Brusciano L, Licia Mozzillo A, Del Genio F, Docimo L. Remission of type 2 diabetes in patients undergoing biliointestinal bypass for morbid obesity: a new surgical treatment. Surg Obes Relat Dis. 2015 Dec 7. pii: S1550-7289(15)01093-X. doi: 10.1016/j.soard.2015.12.003. [Epub ahead of print] PMID: 27150339.

Di Francesco L, Dovizio M, Trenti A, Marcantoni E, Moore A, O'Gaora P, McCarthy C, Tacconelli S, Bruno A, Alberti S, Gizzo S, Nardelli GB, Orso G, Belton O, Trevisi L, Dixon DA, Patrignani P. Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells. Br J Pharmacol. 2015 172(18): 4575-4587.

Elliott JA, Jackson S, King S, McHugh R, Docherty N.G, Reynolds J.V, le Roux C.W.  Gut Hormone Suppression Increases Food Intake After Esophagectomy With Gastric Conduit Reconstruction. Annals of Surgery 262: 824-829; discussion 829-830 2015.

Finucane OM, Lyons CL, Murphy AM, Reynolds CM, … Tierney AC, Morine MJ, Alcala-Diaz JF, Lopez-Miranda J, O'Connor DP, O'Neill LA, McGillicuddy FC, Roche HM. Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity. Diabetes. 64(6):2116-28, 2015.

Gaoatswe G, Kent BD, Corrigan MA, Nolan G, Hogan AE, McNicholas WT, O'Shea D. Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity. Sleep. 2015 Oct 1;38(10):1629-34.

Goldstone AP, Miras AD, Scholtz S, Jackson S, Neff KJ, Pénicaud L, Geoghegan J, Chhina N, Durighel G, Bell JD, Meillon S, le Roux CW. Link between increased satiety gut hormones and reduced food reward following gastric bypass surgery for obesity. J Clin Endocrinol Metab. 2015 Nov 18:jc20152665. [Epub ahead of print] PMID: 26580235.

Jennings P, Crean D, Aschauer L, Limonciel A, Moenks K, Kern G, Hewitt P, Lhotta K, Lukas A, Wilmes A, Leonard MO. 'Interleukin-19 as a Translational Indicator of Renal Injury.' Arch Toxicol. 2015; 89(1):101-6.

Lavelle A, Lennon G, O'Sullivan O, Docherty N, Balfe A, Maguire A, Mulcahy H.E, Doherty G, O'Donoghue D, Hyland J, Ross R.P, Coffey J.C, Sheahan K, Cotter P.D, Shanahan F, Winter D.C, O'Connell PR. Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers. Gut. 64(10):1553-61.2015.

Locke AE, Genetic studies of body mass index yield new insights for obesity biology Nature. 2015 Feb 12;518(7538):197-206.

Maguire PJ, Power KA, O'Higgins AC, Jackson S, Harley R, le Roux CW, Turner MJ. Maternal C-reactive protein in early pregnancy. Eur J Obstet Gynecol Reprod Biol. 2015 Oct;193:79-82.

Marcantoni E, Dovizio M, O Gaora P, Di Francesco L, Bendaya I, Schiavone S, Trenti A, Guillem-Llobat P, Zambon A, Nardelli GB, Trevisi L, Patrignani P, Belton O  Dysregulation of gene expression in human fetal endothelial cells from gestational diabetes in response to TGF-β1. Prostaglandins Other Lipid Mediat. 2015 Mar 26.

Marcone S, Haughton K, Simpson PJ, Belton O, Fitzgerald DJ. Milk-derived bioactive peptides inhibit human endothelial-monocyte interactions via PPAR-γ dependent regulation of NF-κB.J Inflamm (Lond). 2015 Jan 20;12(1):1. doi: 10.1186/s12950-014-0044-1. eCollection 2015.PMID: 25632270.

Mathes CM, Bohnenkamp RA, Blonde GD, Letourneau C, Corteville C, Bueter M, Lutz TA, le Roux CW, Spector AC. Gastric bypass in rats does not decrease appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of sugar and fat. Physiol Behav. 2015 Apr 1;142:179-88.

Mathes CM, Bohnenkamp RA, le Roux CW, Spector AC. Reduced sweet and fatty fluid intake after Roux-en-Y gastric bypass in rats is dependent on experience without change in stimulus motivational potency. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R864-74.

McMorrow AM, Connaughton RM, Lithander FE, Roche HM. Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality. Proc Nutr Soc. 74(01):67-82, 2015.

Minihane AM, Vinoy S, Russell WR, Baka A, Roche HM, et al. Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr. 114(07): 999-1012, 2015. DOI: 10.1017/S0007114515002093 (IF:3.311; C:31).

Miras AD, Chuah LL, Khalil N, Nicotra A, Vusirikala A, Baqai N, Graham C, Ravindra S, Lascaratos G, Oliver N, le Roux CW. Type 2 diabetes mellitus and microvascular complications 1 year after Roux-en-Y gastric bypass: a case-control study. Diabetologia. 2015 Jul;58(7):1443-7. doi: 10.1007/s00125-015-3595-7.

Murphy EP, Crean D. 'Molecular Interactions between NR4A Orphan Nuclear Receptors and NF-kappaB are Required for Appropriate Inflammatory Responses and Immune Cell Homeostasis.' Biomolecules. 2015; 5(3):1302-18.

Nolan KA, Brennan EP, Scholz CC, Cullen C, Ryan A, Taylor CT, Godson C*. Paricalcitol protects against TGF-β1-induced fibrotic responses in hypoxia and stabilises HIF-α in renal epithelia. Exp Cell Res. 2015 Jan 15;330(2):371-81.

O'Connor E, Green S, Kiely C, O'Shea D, Egaña M. Differential effects of age and type 2 diabetes on dynamic vs. peak response of pulmonary oxygen uptake during exercise. J Appl Physiol (1985). 2015 Apr 15;118(8):1031-9. PMID: 25701005.

Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, Lau DC, le Roux CW, Violante Ortiz R, Jensen CB, Wilding JP; SCALE Obesity and Prediabetes NN8022-1839 Study Group. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. New England Journal Medicine. 2015 Jul 2;373(1):11-22.

Pournaras DJ, le Roux CW. Type 2 diabetes: multimodal treatment of a complex disease. Lancet. 2015 Sep 5;386(9997):936-7. doi: 10.1016/S0140-6736(15)00132-4.PMID: 2636945.

Quill B, Irnaten M, Docherty N.G, McElnea E.M, Wallace D.M, Clark A.F, O'Brien C.J. Calcium channel blockade reduces mechanical strain-induced extracellular matrix gene response in lamina cribrosa cells. Br J Ophthalmol. 99(7):1009-14 2015.

Risstad H, Søvik TT, Engström M, Aasheim ET, Fagerland MW, Olsén MF, Kristinsson JA, le Roux CW, Bøhmer T, Birkeland KI, Mala T, Olbers T. Five-year outcomes after laparoscopic gastric bypass and laparoscopic duodenal switch in patients with body mass index of 50 to 60: a randomized clinical trial. JAMA Surg. 2015 Apr;150(4):352-61.

Sam AH, Sleeth ML, Thomas EL, Ismail NA, Mat Daud N, Chambers E, Shojaee-Moradie F, Umpleby M, Goldstone AP, le Roux CW, Bech P, Busbridge M, Laurie R, Cuthbertson DJ, Buckley A, Ghatei MA, Bloom SR, Frost GS, Bell JD, Murphy KG. Circulating pancreatic polypeptide concentrations predict visceral and liver fat content. J Clin Endocrinol Metab. 2015 Mar;100(3):1048-52.

Sathyapalan T, Thatcher NJ, Hammersley R, Rigby AS, Courts FL, Pechlivanis A, Gooderham NJ, Holmes E, le Roux CW, Atkin SL. Aspartame sensitivity? A double blind randomised crossover study. PLoS One. 2015 Mar 18;10(3):e0116212. doi: 10.1371/journal.pone.0116212. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0126039.

Shungin D New genetic loci link adipose and insulin biology to body fat distribution. Nature. 2015 Feb 12;518(7538):187-96.

Somerville R, McKenzie K, Eslami S, Breen C, O'Shea D, Wall P. Poor mental health in severely obese patients is not explained by the presence of comorbidities. Clin Obes. 2015 Feb;5(1):12-21.

Spector AC, le Roux CW, Munger SD, Travers SP, Sclafani A, Mennella JA. Proceedings of the 2015 A.S.P.E.N. Research Workshop-Taste Signaling: Impact on Food Selection, Intake, and Health. JPEN J Parenter Enteral Nutr. 2015 Nov 23. pii: 0148607115617438. [Epub ahead of print] PMID: 26598504.

Todd JN, Dahlström EH, Salem RM, Sandholm N, Forsblom C; FinnDiane Study Group, McKnight AJ, Maxwell AP, Brennan E, Sadlier D, Godson C, Groop PH, Hirschhorn JN, Florez JC. Genetic Evidence for a Causal Role of Obesity in Diabetic Kidney Disease. Diabetes. 2015 Dec;64(12):4238-46.

Tremaroli V, Karlsson F, Werling M, Ståhlman M, Kovatcheva-Datchary P, Olbers T, Fändriks L, le Roux CW, Nielsen J, Bäckhed F. Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation. Cell Metab. 2015 Aug 4;22(2):228-38.

Werling M, Fändriks L, Olbers T, Bueter M, Sjöström L, Lönroth H, Wallenius V, Stenlöf K, le Roux CW. Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake. PLoS One. 2015 Jun 22;10(6):e0129784.

Wu Q, Li JV, Seyfried F, le Roux CW, Ashrafian H, Athanasiou T, Fenske W, Darzi A, Nicholson JK, Holmes E, Gooderham NJ. Metabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgery. Int J Obes (Lond). 2015 Jul;39(7):1126-34.

Ahern T, Khattak A, O'Malley E, Dunlevy C, Kilbane M, Woods C, McKenna MJ, O'Shea D. Association Between Vitamin D Status and Physical Function in the Severely Obese. J Clin Endocrinol Metab. 2014 Apr 15:jc20141704. 

Angelopoulos T, Kokkinos A, Liaskos C, Tentolouris N, Alexiadou K, Miras AD, Mourouzis I, Perrea D, Pantos C, Katsilambros N, Bloom SR, le Roux CW. The effect of slow spaced eating on hunger and satiety in overweight and obese patients with type 2 diabetes mellitus. BMJ Open Diabetes Res Care. 2014 Jul 2;2(1).

Bächler T, Schiesser M, Lutz TA, le Roux CW, Bueter M. Where to begin and where to end? Preoperative assessment for patients undergoing metabolic surgery. Dig Surg. 2014;31(1):25-32.

Bhutta HY, Deelman TE, le Roux CW, Ashley SW, Rhoads DB, Tavakkoli A. Intestinal sweet-sensing pathways and metabolic changes after Roux-en-Y gastric bypass surgery. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G588-93.

Breen C, Ryan M, McNulty B, Gibney MJ, Canavan R, O'Shea D. High saturated-fat and low-fibre intake: a comparative analysis of nutrient intake in individuals with and without type 2 diabetes. Nutr Diabetes. 2014 Feb 3;4:e104.

Carswell KA, Vincent RP, Belgaumkar AP, Sherwood RA, Amiel SA, Patel AG, le Roux CW. The effect of bariatric surgery on intestinal absorption and transit time. Obes Surg. 2014 May;24(5):796-805.

Elias E, Casselbrant A, Werling M, Abegg K, Vincent RP, Alaghband-Zadeh J, Olbers T, le Roux CW, Fändriks L, Wallenius V. Bone mineral density and expression of vitamin D receptor-dependent calcium uptake mechanisms in the proximal small intestine after bariatric surgery. Br J Surg. 2014 Nov;101(12):1566-75. doi: 10.1002/bjs.9626. Epub 2014 Sep 10.

Goyale A, Ashley SL, Taylor DR, Elnenaei MO, Alaghband-Zadeh J, Sherwood RA, le Roux CW, Vincent RP. Predicting refeeding hypophosphataemia: Insulin growth factor 1 (IGF-1) as a diagnostic biochemical marker for clinical practice. Ann Clin Biochem. 2014 Mar 7.

Hickey FB, Corcoran JB, Griffin B, Bhreathnach U, Mortiboys H, Reid HM, Andrews D, Byrne S, Furlong F, Martin F, Godson C*, Murphy M. IHG-1 increases mitochondrial fusion and bioenergetic function.  Diabetes. 2014 Dec;63(12):4314-25.

Jimenez-Gomez Y, Cruz-Teno C, Rangel-Zuñiga OA, Peinado JR, Perez-Martinez P, Delgado-Lista J, Garcia-Rios A, Camargo A, Vazquez-Martinez R, Ortega-Bellido M, Perez-Jimenez F, Roche HM, Malagon MM, Lopez-Miranda J. Effect of  dietary fat modification on subcutaneous white adipose tissue insulin sensitivity in patients with metabolic syndrome. Mol Nutr Food Res Nov;58(11):2177-88, 2014 .

Kim JY, Ha TK, le Roux CW. Metabolic effects of gastrectomy with or without omentectomy in gastric cancer. Hepatogastroenterology. 2014 Sep;61(134):1830-4.

Laurenius A, Werling M, Le Roux CW, Fändriks L, Olbers T. More symptoms but similar blood glucose curve after oral carbohydrate provocation in patients with a history of hypoglycemia-like symptoms compared to asymptomatic patients after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2014 Apr 18. pii: S1550-7289(14)00156-7. doi: 10.1016/j.soard.2014.04.007.

Lennon G, Balfe Á, Bambury N, Lavelle A, Maguire A, Docherty N.G, Coffey J.C, Winter D.C, Sheahan K, O'Connell PR. Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis. Colorectal Dis. 16(5):O161-169. 2014.

Lyons T, Neff KJ, Benn J, Chuah LL, le Roux CW, Gilchrist M. Body mass index and diabetes status do not affect postoperative infection rates after bariatric surgery. Surg Obes Relat Dis. 2014 Mar-Apr;10(2):291-7.

McAllan L, Skuse P, Cotter PD, O'Connor P, Cryan JF, Ross RP, Fitzgerald G,        Roche HM, Nilaweera, KN. Protein quality and the protein to carbohydrate ratio within a high fat diet influences energy balance and fatty acids and  polyphenols. Mol Nutr Food Res. 58(8):1708-1720, 2014.

McElnea E.M, Hughes E, McGoldrick A, McCann A, Quill B, Docherty N, Irnaten M,  Farrell M, Clark A.F, O'Brien C.J, Wallace D.M. Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells. BMC Ophthalmol. 14:153. 2014.

Miras AD, Al-Najim W, Jackson SN, McGirr J, Cotter L, Tharakan G, Vusirikala A, le Roux CW, Prechtl CG, Scholtz S. Psychological characteristics, eating behavior, and quality of life assessment of obese patients undergoing weight loss interventions. Scand J Surg. 2014 Jul 22.

Miras AD, Risstad H, Baqai N, Law S, Søvik TT, Mala T, Olbers T, Kristinsson JA, le Roux CW. Application of the International Diabetes Federation and American Diabetes Association criteria in the assessment of metabolic control after bariatric surgery. Diabetes Obes Metab. 2014 Jan;16(1):86-9.

Miras AD, Seyfried F, Phinikaridou A, Andia ME, Christakis I, Spector AC, Botnar RM, le Roux CW. Rats fed diets with different energy contribution from fat do not differ in adiposity. Obes Facts. 2014;7(5):302-10.

Neff KJ, Chuah LL, Aasheim ET, Jackson S, Dubb SS, Radhakrishnan ST, Sood AS, Olbers T, Godsland IF, Miras AD, le Roux CW. Beyond weight loss: evaluating the multiple benefits of bariatric surgery after Roux-en-Y gastric bypass and adjustable gastric band. Obes Surg. 2014 May;24(5):684-91.

Neff KJ, Prener C, Chuah LL, O'Donnell K, Godsland IF, Miras AD, le Roux CW. A holistic assessment of bariatric surgical outcomes in a Northern Irish cohort. Ir Med J. 2014 Jan;107(1):24-6.

O'Grada CM, Morine MJ, Morris C, Ryan M, Dillon ET, Walsh M, Gibney ER, Brennan L, Gibney MJ, Roche HM.  PBMCs reflect the immune component of the WAT transcriptome--implications as biomarkers of metabolic health in the postprandial state. Mol Nutr Food Res. 58(4):808-20, 2014.

Papamargaritis D, Aasheim ET, Sampson B, le Roux CW. Copper, selenium and zinc levels after bariatric surgery in patients recommended to take multivitamin-mineral supplementation. J Trace Elem Med Biol. 2014 Sep 16. pii: S0946-672X(14)00174-6.

Rodríguez-Peña A.B, Fuentes-Calvo I, Docherty N.G, Arévalo M, Grande M.T, Eleno N, Pérez-Barriocanal F, López-Novoa J.M. Effect of angiotensin II and small GTPase Ras signaling pathway inhibition on early renal changes in a murine model of obstructive nephropathy. Biomed Res Int. 2014:124902 2014.

Salinari S, le Roux CW, Bertuzzi A, Rubino F, Mingrone G. Duodenal-jejunal bypass and jejunectomy improve insulin sensitivity in Goto-Kakizaki diabetic rats without changes in incretins or insulin secretion. Diabetes. 2014 Mar;63(3):1069-78.

Scholtz S, Miras AD, Chhina N, Prechtl CG, Sleeth ML, Daud NM, Ismail NA, Durighel G, Ahmed AR, Olbers T, Vincent RP, Alaghband-Zadeh J, Ghatei MA, Waldman AD, Frost GS, Bell JD, le Roux CW, Goldstone AP. Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding. Gut. 2014 Jun;63(6):891-902.

Seyfried F, Bueter M, Spliethoff K, Miras AD, Abegg K, Lutz TA, le Roux CW. Roux-en Y Gastric Bypass Is Superior to Duodeno-Jejunal Bypass in Improving Glycaemic Control in Zucker Diabetic Fatty Rats. Obes Surg. 2014 Jun 15.

Tako AA, Kotiadis K, Vasilakis C, Miras A, le Roux CW. Improving patient waiting times: a simulation study of an obesity care service. BMJ Qual Saf. 2014 May;23(5):373-81.

Taylor DR, Alaghband-Zadeh J, Cross GF, Omar S, le Roux CW, Vincent RP. Urine bile acids relate to glucose control in patients with type 2 diabetes mellitus and a body mass index below 30 kg/m2. PLoS One. 2014 Apr 15;9(4):e93540.

Tobin AM, Hackett CB, Rogers S, Collins P, Richards HL, O'Shea D, Kirby B. Body Mass Index, Waist Circumference and HOMA-IR correlate with PASI in psoriasis patients receiving phototherapy. Br J Dermatol. 2014 Feb 23.

Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC. Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation. Diabetes. 63(6):2037-50, 2014.

Werling M, Fändriks L, Royce VP, Cross GF, le Roux CW, Olbers T. Preoperative assessment of gut hormones does not correlate to weight loss after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2014 Sep-Oct;10(5):822-8.

Yang S, Wang B, Humphries F, Hogan AE, O'Shea D, Moynagh PN. The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance. Immunity. 2014 Dec 18;41(6):973-87.

Brennan EP, Nolan KA, Borgeson E,  Gough OS, McEvoy C, Docherty NG, Higgins DF, Murphy M, Sadlier DM,Ali-Shah T, Guiry PJ, The GENIE Consortium, Savage D, Maxwell AP, Martin F, Godson C* Lipoxins attenuate renal fibrosis by induction of let-7c and suppression of TGFβR1 J Am Soc Nephrol 2013, 24(4):627-37.

Briggs AD, Mytton OT, Madden D, O'Shea D, Rayner M, Scarborough P. The potential impact on obesity of a 10% tax on sugar-sweetened beverages in Ireland, an effect assessment modelling study. BMC Public Health. 2013 Sep 17;13:860.

Carolan E, Hogan AE, Corrigan M, Gaotswe G, O'Connell J, Foley N, O'Neill LA, Cody D, O'Shea D. The impact of childhood obesity on inflammation, innate immune cell frequency and metabolic microRNA expression. J Clin Endocrinol Metab. 2013 Jan 1.

Cohen R, le Roux CW, Papamargaritis D, Salles JE, Petry T, Correa JL, Pournaras DJ, Galvao Neto M, Martins B, Sakai P, Schiavon CA, Sorli C. Role of proximal gut exclusion from food on glucose homeostasis in patients with Type 2 diabetes. Diabet Med. 2013 Jun 26. doi: 10.1111/dme.12268.

de Gaetano M, Dempsey E, Marcone S, James WG, Belton O. Conjugated linoleic acid targets β2 integrin expression to suppress monocyte adhesion. J Immunol. 2013 Oct 15;191(8):4326-36.

de Jonge C, Rensen SS, Verdam FJ, Vincent RP, Bloom SR, Buurman WA, le Roux CW, Schaper NC, Bouvy ND, Greve JW. Endoscopic duodenal-jejunal bypass liner rapidly improves type 2 diabetes. Obes Surg. 2013 Sep;23(9):1354-60.

Faherty, N., O’Donovan, H.C., Kavanagh, D., Madden, S., McKay, G.J., Maxwell, A.P., Martin, F., Godson, C. and Crean, J. TGF-beta and CCN2/CTGF mediate actin related gene expression by differential E2F1/CREB activation. BMC Genomics 2013, 14:525  doi:10.1186/1471-2164-14-525.

Hogan AE, Gaoatswe G, Lynch L, Corrigan MA, Woods C, O'Connell J, O'Shea D. Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetologia. 2013 Dec 21.

Irnaten M, Barry R.C, Wallace D.M, Docherty N.G, Quill B, Clark A.F, O'Brien C.J. Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells. Exp Eye Res. 115C:224-229. 2013

Kavanagh, D., Savage, D.A., Patterson, C., McKnight, A.J., Crean, J., Alexander P Maxwell, A.P.,  McKay, G.J. Haplotype association analysis of genes within the WNT signalling pathways indiabetic nephropathy BMC Nephrology 2013, 14:126.

Lynch, J., Meehan, M.H., Crean, J., Copeland, J., Stallings, R.L., Bray, I.M. Metastasis Suppressor microRNA-335 Targets the Formin Family of Actin Nucleators. PLoS One. 2013 Nov 5;8(11).

McArdle MA, Finucane OM, Connaughton RM, McMorrow AM, Roche HM. Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies. Front. Endocrinol 4, 52, 2013.

McCarthy C, Duffy MM, Mooney D, James WG, Griffin MD, Fitzgerald DJ, Belton O. IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis. FASEB J. 2013 Feb;27(2):499-510.

 McCarthy C, Lieggi NT, Barry D, Mooney D, de Gaetano M, James WG, McClelland S, Barry MC, Escoubet-Lozach L, Li AC, Glass CK, Fitzgerald DJ, Belton O Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid. EMBO Mol Med. 2013 Sep;5(9):1443-57.

O'Shea D, Corrigan M, Dunne MR, Jackson R, Woods C, Gaoatswe G, Moynagh PN, O'Connell J, Hogan AE. Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection Int J Obes (Lond). 2013 Feb.

Osto M, Abegg K, Bueter M, le Roux CW, Cani PD, Lutz TA. Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine. Physiol Behav. 2013 Jul 2;119:92-6.

Phillips CM, Tierney AC, Perez-Martinez P, Defoort C, Blaak EE, Gjelstad IMF, Lopez-Miranda J, Kiec-Klimczak M, Malczewska-Malec M, Drevon CA, Hall W, Lovegrove JA, Karlstrom B, Risérus U, Roche HM. Obesity and body fat classification in the metabolic syndrome: Impact on cardiometabolic risk metabotype.  Obesity 21 (1): E154-E161, 2013.

Pournaras DJ, le Roux CW. Are bile acids the new gut hormones? Lessons from weight loss surgery models. Endocrinology. 2013 Jul;154(7):2255-6.

Sam AH, Busbridge M, Amin A, Webber L, White D, Franks S, Martin NM, Sleeth M, Ismail NA, Daud NM, Papamargaritis D, le Roux CW, Chapman RS, Frost G, Bloom SR, Murphy KG. Hepcidin levels in diabetes mellitus and polycystic ovary syndrome. Diabet Med. 2013 Jun 24. doi: 10.1111/dme.12262.

Seyfried F, Miras AD, Bueter M, Prechtl CG, Spector AC, le Roux CW. Effects of preoperative exposure to a high-fat versus a low-fat diet on ingestive behavior after gastric bypass surgery in rats. Surg Endosc. 2013 Nov;27(11):4192-201.